DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment snRNP-U1-70K and Snrnp70

DIOPT Version :9

Sequence 1:	NP_001260173.1	Gene:	snRNP-U1-70K / 33982	FlyBaseID:	FBgn0016978	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_033250.3	Gene:	Snrnp70 / 20637	MGIID:	98341	Length:	448	Species:	Mus musculus

Alignment Length:	412	Identity:	212/412 - (51%)
Similarity:	270/412 - (65%)	Gaps:	59/412 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTQYLPPNLLALFAAREPIPFMPPVDKLPHEK-KSRGYLGVAKFMADFEDPKDTPLPKTVETRQE 64
            |||:||||||||||.|:|||::||::|||||| .::.|.|:|.::.:||||:|.|.|...|||:|
Mouse     1 MTQFLPPNLLALFAPRDPIPYLPPLEKLPHEKHHNQPYCGIAPYIREFEDPRDAPPPTRAETREE 65

  Fly    65 RLERRRREKAEQVAYKLEREIALWDPTEIKNATEDPFRTLFIARINYDTSESKLRREFEFYGPIK 129
            |:||:||||.|:...::|.|:.:|||....||..|.|:|||:||:||||:|||||||||.|||||
Mouse    66 RMERKRREKIERRQQEVETELKMWDPHNDPNAQGDAFKTLFVARVNYDTTESKLRREFEVYGPIK 130

  Fly   130 KIVLIHDQESGKPKGYAFIEYEHERDMHAAYKHADGKKIDSKRVLVDVERARTVKGWLPRRLGGG 194
            :|.:::.:.||||:||||||||||||||:|||||||||||.:||||||||.||||||.|||||||
Mouse   131 RIHMVYSKRSGKPRGYAFIEYEHERDMHSAYKHADGKKIDGRRVLVDVERGRTVKGWRPRRLGGG 195

  Fly   195 LGGTRRGGNDVNIKHSGREDNERERERYRLEREREDREGPGRGGGSNGLDARPGRGFGAERRRSR 259
            ||||||||.||||:||||:|..|          .::|.||         ...|.|    :|.|.|
Mouse   196 LGGTRRGGADVNIRHSGRDDTSR----------YDERPGP---------SPLPHR----DRDRDR 237

  Fly   260 SRERRDRERDRGRGAVASNGRSRSRSRERRKRRAGSRERYDEFDRRDRRDRERERDRDREREKKK 324
            .||||:|.|:|.:    ...|.|||||:|| ||:.||:       :|.|.|.|||.:|::|::|:
Mouse   238 ERERRERSRERDK----ERERRRSRSRDRR-RRSRSRD-------KDERRRSRERSKDKDRDRKR 290

  Fly   325 KRSKSRERESSRERRERKRERR------DRERGTGSGGDVKERKPDFRDMDVIKIKEEPVDDGYP 383
            :.|:||||  :|..||||.|.|      ....|.|.|||:.|..         :..:...|||.|
Mouse   291 RSSRSRER--ARRERERKEELRGGGGGGGGGSGGGGGGDMAEPS---------EAGDGAPDDGPP 344

  Fly   384 TFDYQNATIKREIDDEDEEKYR 405
                  ..:..|..|..|||.|
Mouse   345 ------GELGPEGPDGPEEKGR 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snRNP-U1-70K	NP_001260173.1	U1snRNP70_N	2..92	CDD:289024	51/90 (57%)
		RRM	<97..>179	CDD:223796	61/81 (75%)
		RRM_snRNP70	101..188	CDD:240682	68/86 (79%)
Snrnp70	NP_033250.3	U1snRNP70_N	3..93	CDD:371969	50/89 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..79		19/30 (63%)
		Required for interaction with U1 RNA. /evidence=ECO:0000250\|UniProtKB:P08621	92..202		83/109 (76%)
		RRM_snRNP70	102..187	CDD:240682	66/84 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..439		90/226 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849266
Domainoid	1	1.000	142	1.000	Domainoid score	I4688
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	383	1.000	Inparanoid score	I2033
Isobase	1	0.950	-	0	Normalized mean entropy	S1470
OMA	1	1.010	-	-		QHG54339
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102349
Panther	1	1.100	-	-	LDO	PTHR13952
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1267
SonicParanoid	1	1.000	-	-		X3654
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880