Protein Alignment snRNP-U1-70K and Srsf1

DIOPT Version :10

• Sequence 1: NP_477205.1
• Gene: snRNP-U1-70K / 33982
• FlyBaseID: FBgn0016978
• Length: 448
• Species: Drosophila melanogaster
• Sequence 2: NP_775550.2
• Gene: Srsf1 / 110809
• MGIID: 98283
• Length: 248
• Species: Mus musculus
• Alignment Length: 303
• Identity: 66/303 - (21%)
• Similarity: 86/303 - (28%)
• Gaps: 136/303 - (44%)

  Fly   104 LFIARINYDTSESKLRREFEFYGPIKKIVLIHDQESGKPKGYAFIEYEHERDMHAAYKHADGKKI 168
            :::..:..|.....:...|..||.|:.|.| .::..|.|  :||:|:|..||...|....||...
Mouse    18 IYVGNLPPDIRTKDIEDVFYKYGAIRDIDL-KNRRGGPP--FAFVEFEDPRDAEDAVYGRDGYDY 79

  Fly   169 DSKRVLVDVERARTVKGWLPRRLGGGLGGTRRGGNDVNIKHSGREDNERERERYRLEREREDREG 233
            |..|:.|:..|                              |||                    |
Mouse    80 DGYRLRVEFPR------------------------------SGR--------------------G 94

  Fly   234 PGRGGGSNGLDARPGRGFGAERRRSRSR-------------ERRDRERDRG-------------- 271
            .|||||..|....|...:|...|||.:|             :.:|..|:.|
Mouse    95 TGRGGGGGGGGGAPRGRYGPPSRRSENRVVVSGLPPSGSWQDLKDHMREAGDVCYADVYRDGTGV 159

  Fly   272 ------------------------RGAVA------------SNGRSRSRSRERRKRRAGSRERYD 300
                                    .|..|            |.||||||||.
Mouse   160 VEFVRKEDMTYAVRKLDNTKFRSHEGETAYIRVKVDGPRSPSYGRSRSRSRS------------- 211

  Fly   301 EFDRRDRRDRERERDRDREREKKKKRSKSRERESSRERRERKR 343
                   |.|.|.|...|.|....:||:...|.|.|..|.|.|
Mouse   212 -------RSRSRSRSNSRSRSYSPRRSRGSPRYSPRHSRSRSR 247

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
snRNP-U1-70K	NP_477205.1	U1snRNP70_N	3..92	CDD:432406
		RRM_snRNP70	101..188	CDD:409682	22/83 (27%)
Srsf1	NP_775550.2	RRM1_SRSF1	12..90	CDD:410010	21/74 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	88..134		17/95 (18%)
		RRM2_SRSF1	113..196	CDD:410160	10/82 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	191..248		23/77 (30%)
		Interaction with SAFB1. /evidence=ECO:0000250	198..247		22/68 (32%)