Protein Alignment Hmgcl and LYS20

DIOPT Version :9

• Sequence 1: NP_001285696.1
• Gene: Hmgcl / 33978
• FlyBaseID: FBgn0031877
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_010099.1
• Gene: LYS20 / 851346
• SGDID: S000002341
• Length: 428
• Species: Saccharomyces cerevisiae
• Alignment Length: 260
• Identity: 59/260 - (22%)
• Similarity: 113/260 - (43%)
• Gaps: 43/260 - (16%)

  Fly    14 AKRTAVTSAANQVRIVEVGPRDGLQNEPKLLPAATKIELINQLSETGLRTIEATSFVSAKW---- 74
            ||.....|..|..::::...|:|.|..........|||:...|.:.|:..||.||.|:::.
Yeast    11 AKPGDYLSNVNNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKD 75

  Fly    75 ---VPQMGDNAEVLKGIRKVTGISYPVLTPNLKGFESALEAGAEEVAVFGAASDAFSL----KNV 132
               :.::|..|::|..||           .::...:.|:|.|.:.|.|....|.....    |::
Yeast    76 CEAICKLGLKAKILTHIR-----------CHMDDAKVAVETGVDGVDVVIGTSKFLRQYSHGKDM 129

  Fly   133 NCTAAEAIERFKPVLKAAQKHGVRVR-----GYVSTVVGCPYEGAVAPSAVVKVVEALYQMGCYE 192
            |..|..|:|    |::..:..|:.:|     .:.|.:|.           ::.:.:.:.::|...
Yeast   130 NYIAKSAVE----VIEFVKSKGIEIRFSSEDSFRSDLVD-----------LLNIYKTVDKIGVNR 179

  Fly   193 ISLGDTIGVGTPGTMRRMLDEVTKVVPAKDLAVHCHDTYGQALSNILVSLDYGIRVVDSSVSGLG 257
            :.:.||:|...|..:..::..:..||.. |:..|.|:..|.|::|...:|:.|.|::|.||.|:|
Yeast   180 VGIADTVGCANPRQVYELIRTLKSVVSC-DIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIG 243

  Fly   258  257
            Yeast   244  243

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmgcl	NP_001285696.1	HMGL-like	25..299	CDD:279072	55/249 (22%)
		DRE_TIM_HMGL	28..300	CDD:163676	55/246 (22%)
LYS20	NP_010099.1	DRE_TIM_HCS	23..284	CDD:163685	55/248 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343032
Domainoid	1	1.000	54	1.000	Domainoid score	I2763
eggNOG	1	0.900	-	-		E1_COG0119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	57	1.000	Inparanoid score	I1795
Isobase	1	0.950	-	0	Normalized mean entropy	S1950
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46564
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4186
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.770