Protein Alignment Hmgcl and HMGCLL1

DIOPT Version :9

• Sequence 1: NP_001285696.1
• Gene: Hmgcl / 33978
• FlyBaseID: FBgn0031877
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_061909.2
• Gene: HMGCLL1 / 54511
• HGNCID: 21359
• Length: 370
• Species: Homo sapiens
• Alignment Length: 289
• Identity: 179/289 - (61%)
• Similarity: 232/289 - (80%)
• Gaps: 0/289 - (0%)

  Fly    26 VRIVEVGPRDGLQNEPKLLPAATKIELINQLSETGLRTIEATSFVSAKWVPQMGDNAEVLKGIRK 90
            |:|||||||||||||..::|...|||.||:||:|||..||.|||||::|||||.|:.||:|||.:
Human    78 VKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQMADHTEVMKGIHQ 142

  Fly    91 VTGISYPVLTPNLKGFESALEAGAEEVAVFGAASDAFSLKNVNCTAAEAIERFKPVLKAAQKHGV 155
            ..|:.||||||||:||..|:.|||.|::||||||::||.||:||:..|::.:|:.|:|:|:...:
Human   143 YPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFSKKNINCSIEESMGKFEEVVKSARHMNI 207

  Fly   156 RVRGYVSTVVGCPYEGAVAPSAVVKVVEALYQMGCYEISLGDTIGVGTPGTMRRMLDEVTKVVPA 220
            ..|||||..:||||||::.|..|.:|.:.||.||||||||||||||||||:|:|||:.|.|.:|.
Human   208 PARGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLGDTIGVGTPGSMKRMLESVMKEIPP 272

  Fly   221 KDLAVHCHDTYGQALSNILVSLDYGIRVVDSSVSGLGGCPYAKGASGNAATEDVVYLLHGMGLDT 285
            ..|||||||||||||:|||.:|..||.||||:||||||||||||||||.||||::|:|:|:||:|
Human   273 GALAVHCHDTYGQALANILTALQMGINVVDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGLNT 337

  Fly   286 GVNLDKLIQVGRYICTELGRTSESKVNRA 314
            ||||.|:::.|.:||..:.:|:.|||.:|
Human   338 GVNLYKVMEAGDFICKAVNKTTNSKVAQA 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmgcl	NP_001285696.1	HMGL-like	25..299	CDD:279072	172/272 (63%)
		DRE_TIM_HMGL	28..300	CDD:163676	171/271 (63%)
HMGCLL1	NP_061909.2	PLN02746	56..366	CDD:178347	178/287 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	373	1.000	Domainoid score	I896
eggNOG	1	0.900	-	-		E1_COG0119
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	388	1.000	Inparanoid score	I2024
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55007
OrthoDB	1	1.010	-	-		D1029775at2759
OrthoFinder	1	1.000	-	-		FOG0002283
OrthoInspector	1	1.000	-	-		otm40515
orthoMCL	1	0.900	-	-		OOG6_101527
Panther	1	1.100	-	-	O	PTHR42738
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4186
SonicParanoid	1	1.000	-	-		X1709
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870