DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hmgcl and Hmgcll1

DIOPT Version :9

Sequence 1:	NP_001285696.1	Gene:	Hmgcl / 33978	FlyBaseID:	FBgn0031877	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_001263401.1	Gene:	Hmgcll1 / 367112	RGDID:	1565090	Length:	343	Species:	Rattus norvegicus

Alignment Length:	289	Identity:	178/289 - (61%)
Similarity:	230/289 - (79%)	Gaps:	0/289 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 VRIVEVGPRDGLQNEPKLLPAATKIELINQLSETGLRTIEATSFVSAKWVPQMGDNAEVLKGIRK 90
            |:|||||||||||||..::|...|||.|||||:|||..||.|||||::|||||.|:|||:.||.:
  Rat    48 VKIVEVGPRDGLQNEKVIVPTDIKIEFINQLSQTGLSVIEVTSFVSSRWVPQMADHAEVMGGIHQ 112

  Fly    91 VTGISYPVLTPNLKGFESALEAGAEEVAVFGAASDAFSLKNVNCTAAEAIERFKPVLKAAQKHGV 155
            ..|:.||||.|||:|.:.|:.|||.|:|||||||::||.||:||:..|::.||:.|:.:|:...:
  Rat   113 YPGVRYPVLVPNLQGLQHAVAAGATEIAVFGAASESFSKKNINCSIEESMGRFEQVISSARHMNI 177

  Fly   156 RVRGYVSTVVGCPYEGAVAPSAVVKVVEALYQMGCYEISLGDTIGVGTPGTMRRMLDEVTKVVPA 220
            .||||||..:||||||::.|..|.:|.:.||.|||||||||||:||||||:|:.||:.|.|.:|.
  Rat   178 PVRGYVSCALGCPYEGSIMPQKVTEVSKRLYSMGCYEISLGDTVGVGTPGSMKTMLESVMKEIPP 242

  Fly   221 KDLAVHCHDTYGQALSNILVSLDYGIRVVDSSVSGLGGCPYAKGASGNAATEDVVYLLHGMGLDT 285
            ..|||||||||||||:|||.:|..||.||||:||||||||||||||||.||||::|:|:||||:|
  Rat   243 GALAVHCHDTYGQALANILTALQMGINVVDSAVSGLGGCPYAKGASGNVATEDLIYMLNGMGLNT 307

  Fly   286 GVNLDKLIQVGRYICTELGRTSESKVNRA 314
            ||:|.|:::.|.:||..:.:|:.|||.:|
  Rat   308 GVDLHKVMEAGDFICKAVNKTTNSKVAQA 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hmgcl	NP_001285696.1	HMGL-like	25..299	CDD:279072	171/272 (63%)
Hmgcl	NP_001285696.1	DRE_TIM_HMGL	28..300	CDD:163676	170/271 (63%)
Hmgcll1	NP_001263401.1	PLN02746	41..336	CDD:178347	177/287 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	372	1.000	Domainoid score	I863
eggNOG	1	0.900	-	-		E1_COG0119
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	387	1.000	Inparanoid score	I1948
OMA	1	1.010	-	-		QHG55007
OrthoDB	1	1.010	-	-		D1029775at2759
OrthoFinder	1	1.000	-	-		FOG0002283
OrthoInspector	1	1.000	-	-		otm44658
orthoMCL	1	0.900	-	-		OOG6_101527
Panther	1	1.100	-	-	O	PTHR42738
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1709
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840