Protein Alignment Hmgcl and Hmgcll1

DIOPT Version :10

• Sequence 1: NP_609089.1
• Gene: Hmgcl / 33978
• FlyBaseID: FBgn0031877
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_776092.1
• Gene: Hmgcll1 / 208982
• MGIID: 2446108
• Length: 343
• Species: Mus musculus
• Alignment Length: 306
• Identity: 187/306 - (61%)
• Similarity: 241/306 - (78%)
• Gaps: 2/306 - (0%)

  Fly    11 ALTAKRTA--VTSAANQVRIVEVGPRDGLQNEPKLLPAATKIELINQLSETGLRTIEATSFVSAK 73
            ||.|.:.|  :......|:|||||||||||||..::|...|||||||||:|||..||.|||||::
Mouse    31 ALDAAQEASQLPGLPEYVKIVEVGPRDGLQNEKVIVPTDIKIELINQLSQTGLSVIEVTSFVSSR 95

  Fly    74 WVPQMGDNAEVLKGIRKVTGISYPVLTPNLKGFESALEAGAEEVAVFGAASDAFSLKNVNCTAAE 138
            |||||.|:|||::|||:..|:.||||||||:||:.|:.|||.|:|||||||::||.||:||:..|
Mouse    96 WVPQMADHAEVMRGIRQYPGVRYPVLTPNLQGFQHAVAAGATEIAVFGAASESFSKKNINCSIEE 160

  Fly   139 AIERFKPVLKAAQKHGVRVRGYVSTVVGCPYEGAVAPSAVVKVVEALYQMGCYEISLGDTIGVGT 203
            ::.||:.|:.:|:...:.||||||..:||||||::.|..|.:|.:.||.||||||||||||||||
Mouse   161 SMGRFQEVISSARHMDIPVRGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLGDTIGVGT 225

  Fly   204 PGTMRRMLDEVTKVVPAKDLAVHCHDTYGQALSNILVSLDYGIRVVDSSVSGLGGCPYAKGASGN 268
            ||:|:.||:.|.|.:|...|||||||||||||:|||.:|..||.||||:||||||||||||||||
Mouse   226 PGSMKMMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSAVSGLGGCPYAKGASGN 290

  Fly   269 AATEDVVYLLHGMGLDTGVNLDKLIQVGRYICTELGRTSESKVNRA 314
            .||||::|:|:||||:|||:|.|:::.|.:||..:.:|:.|||.:|
Mouse   291 VATEDLIYMLNGMGLNTGVDLYKVMEAGEFICKAVNKTTNSKVAQA 336

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmgcl	NP_609089.1	DRE_TIM_HMGL	28..300	CDD:163676	175/271 (65%)
Hmgcll1	NP_776092.1	TIM-like beta/alpha barrel domains	26..336	CDD:473867	186/304 (61%)