DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hmgcl and Y71G12B.10

DIOPT Version :9

Sequence 1:	NP_001285696.1	Gene:	Hmgcl / 33978	FlyBaseID:	FBgn0031877	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_490889.1	Gene:	Y71G12B.10 / 171738	WormBaseID:	WBGene00022150	Length:	318	Species:	Caenorhabditis elegans

Alignment Length:	311	Identity:	173/311 - (55%)
Similarity:	227/311 - (72%)	Gaps:	2/311 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LTAKRTAVTSAANQVRIVEVGPRDGLQNEPKLLPAATKIELINQLSETGLRTIEATSFVSAKWVP 76
            |.|.| |.::|.|:.|:||||.|||||.|.|.:|...|:|||::|||.|.:|:|.|||||.||||
Worm     6 LLANR-AYSTAINRFRVVEVGARDGLQAEKKFVPTEIKVELIDRLSECGFQTVETTSFVSPKWVP 69

  Fly    77 QMGDNAEVLKGIRKVTGISYPVLTPNLKGFESALEAG-AEEVAVFGAASDAFSLKNVNCTAAEAI 140
            |:.|:.|::|..|:..|:|||||.||..|.::||..| .||:||||||||||||||||....:::
Worm    70 QLADHNEIVKKHRRFEGVSYPVLVPNAAGLKNALATGVVEEIAVFGAASDAFSLKNVNSNVEDSL 134

  Fly   141 ERFKPVLKAAQKHGVRVRGYVSTVVGCPYEGAVAPSAVVKVVEALYQMGCYEISLGDTIGVGTPG 205
            ::...|.|.|.::.:|||||||.||||||:|||.|..|.:|.|.|.:.||||:||||||||||..
Worm   135 KKLMEVTKIALENNIRVRGYVSVVVGCPYQGAVQPEMVARVAEKLLESGCYEVSLGDTIGVGTVK 199

  Fly   206 TMRRMLDEVTKVVPAKDLAVHCHDTYGQALSNILVSLDYGIRVVDSSVSGLGGCPYAKGASGNAA 270
            |:.:|||.|.|.|||:.||||.||||||||:|:|:|::.|||..|||::|||||||||||:||.|
Worm   200 TVSKMLDTVLKSVPAEKLAVHFHDTYGQALANVLISIEKGIRSADSSIAGLGGCPYAKGATGNLA 264

  Fly   271 TEDVVYLLHGMGLDTGVNLDKLIQVGRYICTELGRTSESKVNRAWKGPQAR 321
            |||::|.|.|.|.:|||||||:::..::.....|....|:|..|....:::
Worm   265 TEDLLYFLKGNGFETGVNLDKVVETAKWFNEAAGYDKWSRVGAAMMAKKSK 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hmgcl	NP_001285696.1	HMGL-like	25..299	CDD:279072	163/274 (59%)
Hmgcl	NP_001285696.1	DRE_TIM_HMGL	28..300	CDD:163676	162/272 (60%)
Y71G12B.10	NP_490889.1	DRE_TIM_HMGL	21..293	CDD:163676	162/271 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160752
Domainoid	1	1.000	338	1.000	Domainoid score	I586
eggNOG	1	0.900	-	-		E1_COG0119
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H159
Inparanoid	1	1.050	348	1.000	Inparanoid score	I1357
Isobase	1	0.950	-	0	Normalized mean entropy	S1950
OMA	1	1.010	-	-		QHG55007
OrthoDB	1	1.010	-	-		D1029775at2759
OrthoFinder	1	1.000	-	-		FOG0002283
OrthoInspector	1	1.000	-	-		oto19726
orthoMCL	1	0.900	-	-		OOG6_101527
Panther	1	1.100	-	-	LDO	PTHR42738
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4186
SonicParanoid	1	1.000	-	-		X1709
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750