DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hmgcl and Hmgcl

DIOPT Version :9

Sequence 1:	NP_001285696.1	Gene:	Hmgcl / 33978	FlyBaseID:	FBgn0031877	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_032280.2	Gene:	Hmgcl / 15356	MGIID:	96158	Length:	325	Species:	Mus musculus

Alignment Length:	312	Identity:	193/312 - (61%)
Similarity:	238/312 - (76%)	Gaps:	4/312 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RSILALTAKRTAVTSA----ANQVRIVEVGPRDGLQNEPKLLPAATKIELINQLSETGLRTIEAT 67
            |.::.||:.|...||:    ..||:|||||||||||||..::|...||.||:.|||.||..||||
Mouse    10 RRLVGLTSLRAVSTSSMGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLIDMLSEAGLPVIEAT 74

  Fly    68 SFVSAKWVPQMGDNAEVLKGIRKVTGISYPVLTPNLKGFESALEAGAEEVAVFGAASDAFSLKNV 132
            ||||.||||||.|:::|||||:|..||:|||||||:||||.|:.|||:||:||||.|:.|:.||.
Mouse    75 SFVSPKWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAGAKEVSVFGAVSELFTRKNA 139

  Fly   133 NCTAAEAIERFKPVLKAAQKHGVRVRGYVSTVVGCPYEGAVAPSAVVKVVEALYQMGCYEISLGD 197
            ||:..|:.:||..|::|||...:.||||||..:||||||.|:|:.|.:|.:.||.||||||||||
Mouse   140 NCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKVSPAKVAEVAKKLYSMGCYEISLGD 204

  Fly   198 TIGVGTPGTMRRMLDEVTKVVPAKDLAVHCHDTYGQALSNILVSLDYGIRVVDSSVSGLGGCPYA 262
            ||||||||.|:.||..|...||...|||||||||||||:|.||:|..|:.||||||:||||||||
Mouse   205 TIGVGTPGLMKDMLTAVMHEVPVTALAVHCHDTYGQALANTLVALQMGVSVVDSSVAGLGGCPYA 269

  Fly   263 KGASGNAATEDVVYLLHGMGLDTGVNLDKLIQVGRYICTELGRTSESKVNRA 314
            ||||||.||||:||:|:|:|:.|||||.||::.|.:||..|.|.:.|||.:|
Mouse   270 KGASGNLATEDLVYMLNGLGIHTGVNLQKLLEAGDFICQALNRKTSSKVAQA 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hmgcl	NP_001285696.1	HMGL-like	25..299	CDD:279072	179/273 (66%)
Hmgcl	NP_001285696.1	DRE_TIM_HMGL	28..300	CDD:163676	177/271 (65%)
Hmgcl	NP_032280.2	PLN02746	17..325	CDD:178347	190/305 (62%)
		HMGL-like	32..306	CDD:279072	178/273 (65%)
		Microbody targeting signal. /evidence=ECO:0000255	323..325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	374	1.000	Domainoid score	I870
eggNOG	1	0.900	-	-		E1_COG0119
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H159
Inparanoid	1	1.050	390	1.000	Inparanoid score	I1979
Isobase	1	0.950	-	0	Normalized mean entropy	S1950
OMA	1	1.010	-	-		QHG55007
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002283
OrthoInspector	1	1.000	-	-		otm42589
orthoMCL	1	0.900	-	-		OOG6_101527
Panther	1	1.100	-	-	LDO	PTHR42738
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4186
SonicParanoid	1	1.000	-	-		X1709
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.810