DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atac1 and DNAJC2

DIOPT Version :9

Sequence 1:	NP_609088.1	Gene:	Atac1 / 33977	FlyBaseID:	FBgn0031876	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_055192.1	Gene:	DNAJC2 / 27000	HGNCID:	13192	Length:	621	Species:	Homo sapiens

Alignment Length:	316	Identity:	65/316 - (20%)
Similarity:	127/316 - (40%)	Gaps:	65/316 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AEISAEDEDVFH--FETEHLALRGNQCYTNLLRTLAVLQAQRIRVHQQIEELEATQNIYLENPQH 66
            |.::.:::|:..  .:.|...|| |.|.|  ....:..:|:|:::.:::|:|  ...:.|.:.|.
Human   335 ALLAKKEKDIQKKAIKKERQKLR-NSCKT--WNHFSDNEAERVKMMEEVEKL--CDRLELASLQC 394

  Fly    67 MLDKLRNNEPLIADNYITTTVLPDLPTLSPNDEEGGTNE----TPTDASSWTQEANKNRDRSNGR 127
            :      ||.|       |:...::...:...:....||    ...:|.:..::|:||.::|.|.
Human   395 L------NETL-------TSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGG 446

  Fly   128 SENFNRLWTNEEQSRLEQLLIQYPPE-----EVEMRRFGKIAKALG-NRTAQQVYSRVQKYFQKL 186
            ..|.::.|:.::...|.:.:..:|..     || :..:..|..:.| .|||:.|..:. |..|||
Human   447 GGNGSKNWSEDDLQLLIKAVNLFPAGTNSRWEV-IANYMNIHSSSGVKRTAKDVIGKA-KSLQKL 509

  Fly   187 HDAGMPVPGRIPKHRRPGLSKPKI-KLRKSTFFPAHNISLQMPEDDFTFDDLRIPSPASDM---- 246
                       ..|::..::|... |.:|.     |.:   :|:.|......|...|.:|.
Human   510 -----------DPHQKDDINKKAFDKFKKE-----HGV---VPQADNATPSERFEGPYTDFTPWT 555

  Fly   247 -----LLMPASKIEPKIESEYMDADLNAESKRKQELCLK----LLSAIQDEKREME 293
                 ||..|.|..|....|..:....|...|.::.|:|    |:..::.:|...|
Human   556 TEEQKLLEQALKTYPVNTPERWEKIAEAVPGRTKKDCMKRYKELVEMVKAKKAAQE 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atac1	NP_609088.1	SANT	135..185	CDD:197842	12/55 (22%)
Atac1	NP_609088.1	SANT	135..183	CDD:238096	12/53 (23%)
DNAJC2	NP_055192.1	Epitope (recognized by CD8(+) cytotoxic T-lymphocytes)	23..31
		ZUO1	75..368	CDD:227594	8/35 (23%)
		DnaJ	88..158	CDD:278647
		ZRF1-UBD	160..250
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..315
		RAC_head	349..420	CDD:293322	16/88 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	426..453		7/26 (27%)
		SANT	452..508	CDD:197842	12/57 (21%)
		SANT	453..506	CDD:238096	12/54 (22%)
		SANT	551..602	CDD:197842	11/50 (22%)
		SANT	553..600	CDD:238096	10/46 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0724
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900