DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13775 and mig-39

DIOPT Version :9

Sequence 1:	NP_001285694.1	Gene:	CG13775 / 33975	FlyBaseID:	FBgn0031874	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_498871.3	Gene:	mig-39 / 185686	WormBaseID:	WBGene00018369	Length:	943	Species:	Caenorhabditis elegans

Alignment Length:	805	Identity:	149/805 - (18%)
Similarity:	265/805 - (32%)	Gaps:	268/805 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SKKKSNVWQYF-YKTSGTVATCLLCNRNYSRRGRGTTCLRNHLKSKHPPEF-------------- 51
            :.|::.||:|| |..:..::.|::.:..|..:|..|:.|..||| ||..|:
Worm   183 TNKQTPVWKYFVYNKTENLSRCIVGDCTYMLKGPHTSTLACHLK-KHTREYSEFQKLKTEYSRTK 246

  Fly    52 --------------LSL---------------------------------SGDIKYLDL----VK 65
                          |:|                                 ||....:||    .|
Worm   247 LDQQPKIPDGAPHPLTLQTQNTPRQTGSPASTCNTNSNTSSSVSSGSGIGSGSGSTMDLSMKKPK 311

  Fly    66 SEISI-------------------GSPQHPTA----------------QLELN-LH--------- 85
            .|.|.                   |||  ||.                .|::| ||
Worm   312 KEPSSAKLNEMLFNGLRQATNNSNGSP--PTTPHAPQLPNIPSFVTNMMLQMNPLHMMLAQSLPG 374

  Fly    86 ETDSDPLDTE-----------------DISYSK--RCDEK----------LALMLLNHSFEFIEG 121
            .|...|..:.                 .|..||  |.|:|          |||...:..||.::.
Worm   375 ATPPTPTSSNAGLNALQQAGLTLAANGQIIQSKKWRNDDKKQKELCTKFALALATSHVDFEVVQN 439

  Fly   122 PGFVNFIRTLQPRYTIQPRSYYEKILCEDIQRKMHQHLKQQVD-------LLDAISLSTSLWRGD 179
            |.:.......||:::|...|.||.|: .....|:.|.||.|:.       |||...::..:.|..
Worm   440 PLWKEVFEMAQPKFSIPTESQYEHIV-NSTSHKLIQSLKSQLSASKKLNLLLDITKITADISRVT 503

  Fly   180 KGEGLLSLSCSGISRDFQTHRLMLKCEALNYESTSKLACCIRDLVPSLAIEVPK-EKIHCVIRDE 243
            ....|    ..|....::|..::|....:|...:..|......::....|.... .::.|...:|
Worm   504 VSVAL----TGGAGNSYETQVILLAFRNINGNQSEDLTAVFEKVLQDYNISPSSINRVICSGLNE 564

  Fly   244 MTALPGSLP---DCSVHRLQMCVRFALQSNELLQNLSSKCKQIVDHF----ASSKMANDHLKFIQ 301
            : |.|..||   |....||..|.:..|:::..::.|......::..:    |:.::|:..||...
Worm   565 L-AEPAELPKQMDSFSSRLANCFKSWLETSPTVEVLKKNVYAMLVSYLTVPAAIQLASQMLKAKF 628

  Fly   302 EIRLTRDPCTLTPYDPCQWNSAFQMMSSVFRMKDALSLYCEEYSLVQIYPDEWIEIDLCSKVMQP 366
            |:.||.      |:        ..::..:...:|...:..|..:|:.  ..||.::.....:|.
Worm   629 EVPLTE------PF--------HVIVEHLVAHRDIYQMNMEGITLIS--EREWNKVTGIHHLMN- 676

  Fly   367 CEETIKIWSNPSTTTSSVIPLVAALRDSLRTDVHNFVSSVTICSFARKLLEELEMKFA------H 425
            ..:....:|...||..:|||.:..:::.|..|:::      :......||..|:...|      |
Worm   677 IFKPFMTYSTDMTTVDTVIPTIVQIQNVLEKDIYH------LGDIGSDLLTSLKQTVAPIMNPEH 735

  Fly   426 ITSDINFLMATYLDPRYKQAFFTEREEQLVANEVLLQ--------------------------LA 464
            ...|..::.||.|:|   |...|...:|:...:.|::                          ||
Worm   736 ENFDSTYIQATALNP---QLAVTLTSDQMTTAKSLIETEISRRTKKMRKAQSDKKLAMGVDSLLA 797

  Fly   465 GVPEDCNG------QPPLKII-----KVSSTSSQKNESKIDSILDSILTTGTTNTQQPNTSMGSQ 518
            .|....:|      :..|.|.     .::..||:..|:.::...|.|.:|.:..:.....:.|:.
Worm   798 NVMRKNDGGSDGGCETALAIYGDLFQSITGNSSESKENIVNQYFDEISSTTSVESMFMLRTFGNP 862

  Fly   519 SQIKNLLYLYNSEPRIDRNMDPLIWWRS-NIKYISLYGIVRKFLSAPAASVVSEGLFRKSTHLYF 582
            .|.                  ||.:|:| :.:...|..:..:.||.|..::.:|.:.
Worm   863 MQA------------------PLSYWKSCSSRCSELSDLATELLSIPIFTLTAERVL-------- 901

  Fly   583 DMQAGLSPESASKMLLMKANFSFSN 607
                ..||:|:|    :..|...:|
Worm   902 ----SFSPDSSS----LNTNLILTN 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13775	NP_001285694.1	zf-BED	6..48	CDD:280965	14/42 (33%)
CG13775	NP_001285694.1	Dimer_Tnp_hAT	525..603	CDD:283379	13/78 (17%)
mig-39	NP_498871.3	Dimer_Tnp_hAT	<866..>902	CDD:283379	9/47 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1121
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46481
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910