Protein Alignment CG13775 and ZBED6

DIOPT Version :10

• Sequence 1: NP_609087.1
• Gene: CG13775 / 33975
• FlyBaseID: FBgn0031874
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_001167579.1
• Gene: ZBED6 / 100381270
• HGNCID: 33273
• Length: 979
• Species: Homo sapiens
• Alignment Length: 749
• Identity: 158/749 - (21%)
• Similarity: 280/749 - (37%)
• Gaps: 206/749 - (27%)

  Fly     4 KKSNVWQYFYKTSGTV--ATCLLCNRNYSRRGR-----GTTCLRNHLKSKHPPEFLSLSGDIKYL 61
            |.|.||.:||.....:  |.|.:|.|:.| |||     ||:.|:.||::.||..:...:.|...:
Human   265 KTSAVWNFFYTDPQHISRAVCNICKRSVS-RGRPGSHLGTSTLQRHLQATHPIHWAVANKDSGAV 328

  Fly    62 ----------------DLVKSEISIGSPQHPTAQLELNLHETDSDP--LDTEDISYS-------- 100
                            |.:..|.|.|| |..||:   :|.::|||.  |:.|:.|.|
Human   329 ANGLDEAETERSDLLSDTLHGEKSTGS-QDLTAE---DLSDSDSDEPMLEVENRSESPIPVAEQG 389

  Fly   101 --KRCDEK----------------LALMLLN--HSFEFIEGPGFVNFIRTLQPRYTIQPRSYY-- 143
              .|..|:                :..|::.  |.:.:...|.|..|::.:.|.|.:...:|:
Human   390 TLMRAQERETTCCGNPVSSHISQAIIQMIVEDMHPYNYFSTPAFQRFMQIVAPDYRLPSETYFFT 454

  Fly   144 -----------EKIL--CEDIQ-RKMHQHLKQQVDLLDAISLSTSLWRGDKGEGLLSLSCSGISR 194
                       |||.  .|::| :|:|              |:..:|..|.......::...:|
Human   455 KAVPQLYDCVREKIFLTLENVQSQKIH--------------LTVDIWTHDPSTDYFIVTVHWVS- 504

  Fly   195 DFQTHRLMLKCEALNYESTSKLA-------CCIRD-----------------LVPSLAI-EVPKE 234
             .:|...:......::...:.|.       |.|.:                 |:||..: :....
Human   505 -LETASFLNNGRIPDFRKWAVLCVTGLAKDCLITNILQELNDQIGLWLSPNFLIPSFIVSDNSSN 568

  Fly   235 KIHCVIRDEMTALPGSLPDCSVHRLQMCVRFALQSNELLQNLSSKCKQIVDHFASSKMA------ 293
            .:|.:.....|.:|     |.:|.|.|.::.....::.::|:....::...||:.|..|
Human   569 VVHAIKDGGFTHVP-----CFLHCLNMVIQDFFCEHKSIENMLVAARKTCHHFSHSVKARQILQE 628

  Fly   294 --NDHLKFIQEIRLTRDPCTLTPYDPCQWNSAFQMMSSVFRMKDALSLYCEEYSL-----VQIYP 351
              |||.  :....|.:|       :...|.|.|.|:..:..     ..|...:||     |.:..
Human   629 FQNDHQ--LPWKNLKQD-------ETGHWISTFYMLKWLLE-----HCYSVHHSLGRASGVVLTS 679

  Fly   352 DEWIEIDLCSKVMQPCEETIKIWSNPSTTTSSVIPLVAALRDSLR-----------TDVHNFVSS 405
            .:|..:.....:::|.||..:..|..:...:.|:||:..|..||:           |...|.|.|
Human   680 LQWTLMTYVCDILKPFEEATQKVSVKTAGLNQVLPLIHHLLLSLQKLREDFQVRGITQALNLVDS 744

  Fly   406 VTICSFARKLLEELEMKFAHITSDINFLMATYLDPRYKQA---FF-----TEREEQLVANEVLLQ 462
            :::     ||  |.:...:.:......::||.|||.:|.:   ||     .|..:|.:|.||...
Human   745 LSL-----KL--ETDTLLSAMLKSKPCILATLLDPCFKNSLEDFFPQGADLETYKQFLAEEVCNY 802

  Fly   463 LAGVPEDCN------GQPPLKIIKVSSTSSQKNESKIDSILDSILTTGTTNTQQPNTSMGSQSQI 521
            :...||.|.      ..|.:.:...|.|||.|..:.....:||        :...|.::||:|
Human   803 MESSPEICQIPTSEASCPSVTVGADSFTSSLKEGTSSSGSVDS--------SAVDNVALGSKS-- 857

  Fly   522 KNLLYLYNSEPRI------------DRNMDPLIWWRSNIK-YISLYGIVRKFLSAPAASVVSEGL 573
                :::.|...:            ....||||:|:..|. :.:|..:..::||.|..|..||.:
Human   858 ----FMFPSAVAVVDEYFKEKYSEFSGGDDPLIYWQRKISIWPALTQVAIQYLSCPMCSWQSECI 918

  Fly   574 FRKSTHLYFDMQAGLSPESASKMLLMKANFSFSN 607
            |.|::|.:......|..::..:::.:|.|....|
Human   919 FTKNSHFHPKQIMSLDFDNIEQLMFLKMNLKNVN 952

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13775	NP_609087.1	zf-BED	6..48	CDD:427043	18/48 (38%)
		Dimer_Tnp_hAT	525..603	CDD:399013	19/90 (21%)
ZBED6	NP_001167579.1	Required for nucleolar localization. /evidence=ECO:0000250|UniProtKB:D2EAC2	1..89
		ZnF_BED	135..182	CDD:214746
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..232
		ZnF_BED	269..315	CDD:214746	17/46 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	333..383		16/53 (30%)
		HATC (Hobo-Ac-Tam3) domain	866..948		18/81 (22%)
		Dimer_Tnp_hAT	868..948	CDD:399013	18/79 (23%)