DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13775 and ZBED6

DIOPT Version :9

Sequence 1:	NP_001285694.1	Gene:	CG13775 / 33975	FlyBaseID:	FBgn0031874	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001167579.1	Gene:	ZBED6 / 100381270	HGNCID:	33273	Length:	979	Species:	Homo sapiens

Alignment Length:	749	Identity:	158/749 - (21%)
Similarity:	280/749 - (37%)	Gaps:	206/749 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KKSNVWQYFYKTSGTV--ATCLLCNRNYSRRGR-----GTTCLRNHLKSKHPPEFLSLSGDIKYL 61
            |.|.||.:||.....:  |.|.:|.|:.| |||     ||:.|:.||::.||..:...:.|...:
Human   265 KTSAVWNFFYTDPQHISRAVCNICKRSVS-RGRPGSHLGTSTLQRHLQATHPIHWAVANKDSGAV 328

  Fly    62 ----------------DLVKSEISIGSPQHPTAQLELNLHETDSDP--LDTEDISYS-------- 100
                            |.:..|.|.|| |..||:   :|.::|||.  |:.|:.|.|
Human   329 ANGLDEAETERSDLLSDTLHGEKSTGS-QDLTAE---DLSDSDSDEPMLEVENRSESPIPVAEQG 389

  Fly   101 --KRCDEK----------------LALMLLN--HSFEFIEGPGFVNFIRTLQPRYTIQPRSYY-- 143
              .|..|:                :..|::.  |.:.:...|.|..|::.:.|.|.:...:|:
Human   390 TLMRAQERETTCCGNPVSSHISQAIIQMIVEDMHPYNYFSTPAFQRFMQIVAPDYRLPSETYFFT 454

  Fly   144 -----------EKIL--CEDIQ-RKMHQHLKQQVDLLDAISLSTSLWRGDKGEGLLSLSCSGISR 194
                       |||.  .|::| :|:|              |:..:|..|.......::...:|
Human   455 KAVPQLYDCVREKIFLTLENVQSQKIH--------------LTVDIWTHDPSTDYFIVTVHWVS- 504

  Fly   195 DFQTHRLMLKCEALNYESTSKLA-------CCIRD-----------------LVPSLAI-EVPKE 234
             .:|...:......::...:.|.       |.|.:                 |:||..: :....
Human   505 -LETASFLNNGRIPDFRKWAVLCVTGLAKDCLITNILQELNDQIGLWLSPNFLIPSFIVSDNSSN 568

  Fly   235 KIHCVIRDEMTALPGSLPDCSVHRLQMCVRFALQSNELLQNLSSKCKQIVDHFASSKMA------ 293
            .:|.:.....|.:|     |.:|.|.|.::.....::.::|:....::...||:.|..|
Human   569 VVHAIKDGGFTHVP-----CFLHCLNMVIQDFFCEHKSIENMLVAARKTCHHFSHSVKARQILQE 628

  Fly   294 --NDHLKFIQEIRLTRDPCTLTPYDPCQWNSAFQMMSSVFRMKDALSLYCEEYSL-----VQIYP 351
              |||.  :....|.:|       :...|.|.|.|:..:..     ..|...:||     |.:..
Human   629 FQNDHQ--LPWKNLKQD-------ETGHWISTFYMLKWLLE-----HCYSVHHSLGRASGVVLTS 679

  Fly   352 DEWIEIDLCSKVMQPCEETIKIWSNPSTTTSSVIPLVAALRDSLR-----------TDVHNFVSS 405
            .:|..:.....:::|.||..:..|..:...:.|:||:..|..||:           |...|.|.|
Human   680 LQWTLMTYVCDILKPFEEATQKVSVKTAGLNQVLPLIHHLLLSLQKLREDFQVRGITQALNLVDS 744

  Fly   406 VTICSFARKLLEELEMKFAHITSDINFLMATYLDPRYKQA---FF-----TEREEQLVANEVLLQ 462
            :::     ||  |.:...:.:......::||.|||.:|.:   ||     .|..:|.:|.||...
Human   745 LSL-----KL--ETDTLLSAMLKSKPCILATLLDPCFKNSLEDFFPQGADLETYKQFLAEEVCNY 802

  Fly   463 LAGVPEDCN------GQPPLKIIKVSSTSSQKNESKIDSILDSILTTGTTNTQQPNTSMGSQSQI 521
            :...||.|.      ..|.:.:...|.|||.|..:.....:||        :...|.::||:|
Human   803 MESSPEICQIPTSEASCPSVTVGADSFTSSLKEGTSSSGSVDS--------SAVDNVALGSKS-- 857

  Fly   522 KNLLYLYNSEPRI------------DRNMDPLIWWRSNIK-YISLYGIVRKFLSAPAASVVSEGL 573
                :::.|...:            ....||||:|:..|. :.:|..:..::||.|..|..||.:
Human   858 ----FMFPSAVAVVDEYFKEKYSEFSGGDDPLIYWQRKISIWPALTQVAIQYLSCPMCSWQSECI 918

  Fly   574 FRKSTHLYFDMQAGLSPESASKMLLMKANFSFSN 607
            |.|::|.:......|..::..:::.:|.|....|
Human   919 FTKNSHFHPKQIMSLDFDNIEQLMFLKMNLKNVN 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13775	NP_001285694.1	zf-BED	6..48	CDD:280965	18/48 (38%)
CG13775	NP_001285694.1	Dimer_Tnp_hAT	525..603	CDD:283379	19/90 (21%)
ZBED6	NP_001167579.1	Required for nucleolar localization. /evidence=ECO:0000250\|UniProtKB:D2EAC2	1..89
		ZnF_BED	135..182	CDD:214746
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	207..232
		ZnF_BED	269..315	CDD:214746	17/46 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..383		16/53 (30%)
		HATC (Hobo-Ac-Tam3) domain	866..948		18/81 (22%)
		Dimer_Tnp_hAT	868..948	CDD:283379	18/79 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157036
Domainoid	1	1.000	92	1.000	Domainoid score	I7607
eggNOG	1	0.900	-	-		E1_KOG1121
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	128	1.000	Inparanoid score	I4675
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223749at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42105
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.800