DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13775 and znf618

DIOPT Version :9

Sequence 1:	NP_001285694.1	Gene:	CG13775 / 33975	FlyBaseID:	FBgn0031874	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001313621.1	Gene:	znf618 / 100330008	ZFINID:	ZDB-GENE-030131-2063	Length:	827	Species:	Danio rerio

Alignment Length:	740	Identity:	141/740 - (19%)
Similarity:	247/740 - (33%)	Gaps:	213/740 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KKKSNVWQYFYKTSGTVATCLLCNRNYSRRG------------RGTTCLRNHLKSKHPPEFLSLS 55
            |:::..:|.....:|:. ||..|.:.|....            :||..|:  |:.|    ....|
Zfish   163 KEEAESFQKMGPKTGSY-TCEYCGKQYKYFNPYQEHVALHAPLKGTFGLK--LEGK----LSGQS 220

  Fly    56 GDIKYLDLVKSEISIGSPQH------PTAQ------------------LE-LNLHETDSDPLDTE 95
            |....:|:..|..|..:|..      |:.|                  || :..|..|::....|
Zfish   221 GQSSRVDINNSHNSSDTPNSRTYTSLPSPQKTYTCGACGIQFQFYNNLLEHMQSHAADNENHVKE 285

  Fly    96 DISYSKRC------DEKL-----ALMLLNHSFEFIEGPGFVNFIRTLQPRYTIQPRSYYEKILCE 149
            |  ..|.|      .|:|     .....||.      |.|.|.:...:.|..:..|..  :::|.
Zfish   286 D--SPKPCPAPAGTQEQLWKSPQPAQQRNHM------PSFQNRLLPEKERQQVAERLL--RVMCV 340

  Fly   150 DI----QRKMHQHLKQQVDLLD------AISLSTSLWRGDKGEGLLSLSCSGISRDFQTHRLMLK 204
            |:    .......||....|:|      |.|:..:|  ||    :.||:...:.|.:...::.:.
Zfish   341 DLGLLGVLSSKDFLKLAQTLVDTGSRNGAYSIREAL--GD----MSSLALKQLPRMYNQVKVKVT 399

  Fly   205 CEALNYESTSKLA--CCIRDLVPSLAI-------------------------EVPKEKIHCV--- 239
            | ||...|:..:|  |..:.:.|....                         |.|::..|.|
Zfish   400 C-ALGSNSSLGIAVTCHSQTVGPDSCYLLTAYQVEGVRLRRYVLGLKEASLRESPEQIHHWVQNV 463

  Fly   240 --------IRDEMTALP--GSLPDCSVHRLQMCVRFA----------------LQSNEL--LQNL 276
                    ||......|  .||..|.  |..:|:|.|                ||:..|  |..|
Zfish   464 LSEFVMSEIRTVYVTEPRLSSLTFCG--RTGICLRCAGCSLTATVQAVLGRRSLQARGLHELGEL 526

  Fly   277 SSKCKQIVDHFASSKMANDHLKFIQEIRLTRDPCTLTPYDPCQWNSAFQMMSSVFRMKDALSLYC 341
            .:.|:.|.   |::       .|..|.:...||..    .|| |::..:.:..|....:|.   |
Zfish   527 LATCRDIA---ATT-------SFNHEGKTAEDPAA----PPC-WDAVAEALLKVHENFEAT---C 573

  Fly   342 EEYS-------LVQIYPDEWIEIDLCSKVMQPCEE-TIKIWSNPSTTTSSVIPLVAALRDSLRTD 398
            |.|.       |:|......:....|  ::.|..: .:::......|..:|:|:...|.....:.
Zfish   574 EAYGRSKSTVPLLQGLNKHLLGTLAC--LLAPLRQAALELSLERCPTLQNVLPVYLRLEKLFTSK 636

  Fly   399 VHNFVSSVTICS-FARKLLEELEMKFAHITSDINFLMATYLDPRYKQAFFTEREEQLVANEVLLQ 462
            .....:...:|. |...|.|..:::..|       .:|..|||:.|.......:.:.:.:.|...
Zfish   637 AGEAGAGSKLCHYFLEALKENFKVERVH-------QVAMILDPQLKLRPVPAYQHEEIISRVCDM 694

  Fly   463 LAGV------------PEDCNGQPPLKIIKVSSTSSQKNESKIDSILDSILTTGTTNTQQPNTSM 515
            .|.:            .::.:|:.|          |.....::|..||           :|:..
Zfish   695 AASMRDLGSGGSAGASVDERDGEGP----------SAPKRGRLDCGLD-----------RPSCD- 737

  Fly   516 GSQSQIKNLLYLYNSEPRIDRNMDPLIWWRSNI-KYISLYGIVRKFLSAPAASVVSEGLFRKSTH 579
            ..:.|::..|:.|..||......|.|.:|.|.: :|..|..:....|:.||.:|..|.:......
Zfish   738 AEEPQVRKELFQYLGEPLFSGTGDLLQYWSSVMDRYPRLSRLALWLLAVPAVAVHGECMSICEQT 802

  Fly   580 LYFDMQAGLSPESASKMLLMKANFS 604
            |....:..::.|..:|::.:|:||:
Zfish   803 LAMKRKQQVTAEEMNKLVFLKSNFA 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13775	NP_001285694.1	zf-BED	6..48	CDD:280965	11/53 (21%)
CG13775	NP_001285694.1	Dimer_Tnp_hAT	525..603	CDD:283379	19/78 (24%)
znf618	NP_001313621.1	C2H2 Zn finger	83..103	CDD:275368
		C2H2 Zn finger	127..147	CDD:275368
		Dimer_Tnp_hAT	746..>788	CDD:283379	11/41 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1121
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900