Protein Alignment SA and IRR1

DIOPT Version :9

• Sequence 1: NP_477268.2
• Gene: SA / 33974
• FlyBaseID: FBgn0020616
• Length: 1127
• Species: Drosophila melanogaster
• Sequence 2: NP_012238.1
• Gene: IRR1 / 854786
• SGDID: S000001288
• Length: 1150
• Species: Saccharomyces cerevisiae
• Alignment Length: 1310
• Identity: 261/1310 - (19%)
• Similarity: 473/1310 - (36%)
• Gaps: 388/1310 - (29%)

  Fly     1 MMARRGGKRIRMDDPPPDYEELHSDALNESTSDADS-----PTKRMTRLRARGGVRDKPPIIDD- 59
            |.|.|...|||.....  .||.:.|..|.|....:|     .|:.........|..::....||
Yeast     1 MTAVRRSTRIRTKSQV--IEEDYDDEQNTSAQHVESDKITAKTQHEEEEEQDTGESEESSSEDDY 63

  Fly    60 ---DEDDFFAPIARKRKTPATRKGPTERKERVERPRKEPVDKG----------HHERIDSER--E 109
               |:||:......|||: ..||..:......:|.:|:|....          |..:.|.::  |
Yeast    64 EDQDDDDYVDTATAKRKS-RKRKPKSASNTSSKRQKKKPTSAQKSAVSHAPAYHRSKKDQDQYLE 127

  Fly   110 ITTD--ENSLYYIVRHSKN-PIASIVDQWIEQYKANRETALVALMQFFINASGCKGKISE-DIQY 170
            |..|  ...|:.|:..|:: .|..::.:|:|.|..||:..|...:...:|..|...::.: |:
Yeast   128 IAKDFQPTELFDILSTSEDVSIEELLREWLETYSENRDKFLQEFINLLLNCCGSVARVEDHDV-- 190

  Fly   171 PVDHTSIIRRMTEEFDEESGE-------------YPLIMSGTQWRK-FK-----NNFCDFVQTLV 216
               |::      |..:|..||             |.||....:.|| ||     .||.:|:..|:
Yeast   191 ---HSN------ESSNETIGEIQLLFQRQKLHEFYLLISKENKKRKNFKMGPLYQNFAEFMTKLL 246

  Fly   217 KQC-QYSIIY-------DQFLMDN-VISLLTGLSD---SQVRAFRHTATLAAMKLMTALVDVALL 269
            :.. ...::|       .|.:..| |:.|||.||.   .::|.||:.:||........|...|:.
Yeast   247 EVANDLQLLYVESDEDDTQIVTGNLVLDLLTWLSSFSVCKIRCFRYISTLTLYLFQDYLTQQAVN 311

  Fly   270 VSNNF-DNAAKQFEAERVKSR-DRRASDRLDSLMTKRSELEENMDEIKSMLTYMFKSVFVHRYRD 332
            :..|: ...:||...|..|.| :.:..::|:|.:   :|.:.:...|.|::..:.|..|||||:|
Yeast   312 LEKNYLAKLSKQLSLEEKKKRPNNKTLEKLESTI---AETQGSKVVIDSIIDNIVKLCFVHRYKD 373

  Fly   333 SLPDIRAICMAEIGIWMENYPQNFLDDSYLKYIGWTLHDKIGEVRLRCLQSLLPLY-----EKDE 392
            ....||:..|..:.||::|||:.||..::|||.||.|.|....|||:..:.|..|.     .|..
Yeast   374 VSDLIRSESMLHLSIWIKNYPEYFLKVTFLKYFGWLLSDNSVSVRLQVTKILPHLIIQNHNSKST 438

  Fly   393 LKGKLELFTSKFKDRIVAMTL-DKEFEVSVHAVKLVISILKIHPEILADKDCEIVYELVYSSH-- 454
            ....:.....:||.:|:.:.: |...:|.:|:::::.....:  ..|.|.:..|:..|::...
Yeast   439 DNSAIRQVFERFKTKILEVAIRDVNLDVRIHSIQVLTEASSL--GYLDDSEILIISSLMFDEEFD 501

  Fly   455 ----------------------RGVAQAAAEFLNVR----------------------------- 468
                                  |.:.:...||:...
Yeast   502 PFKTSSFNKRSKFLSTVAKFLARVIKEKFDEFIKTHEDLPKEVDGLEVGPVVQVGIFIKILNDSL 566

  Fly   469 LFHLTADMEETKTKRGKVRMPNTPLVRDLVQFFIESELHEHGAYLVDSFIDSNDMVRDWECMTDL 533
            ::|| .|..|..: |.|:||        |.|          .|..:..:|.::     .:.:.:|
Yeast   567 IYHL-KDCAEVDS-RTKIRM--------LTQ----------AAEFLSPYISTH-----LKTICNL 606

  Fly   534 LLEEPGPNEEVLDNKQESTLIEIMVSSVKQSATGEVPVGRASNRKCTLSAKELKAIQDEKAKLTE 598
            |:.:...||          ||:.:.:|...::..|                   .:.||:..:|.
Yeast   607 LISDTESNE----------LIQKLQNSANNNSDDE-------------------DVDDEELDITP 642

  Fly   599 HFIVTLPSLL---------------EKYQA-DSEKLANLLAVPQYFDLNLYTTNRQEGNLQALLD 647
            .|.:...|.:               .|.|. ||.|   .:.:|.::||           |.|
Yeast   643 LFPIDRNSTILYLNVFHGLCAGANNPKIQTKDSVK---EIVLPLFYDL-----------LNA--- 690

  Fly   648 RINQVMSMHTGREVLETCAKTLECLCAEGSATYTRCNIARSNIIESAVNKYKDAIEEWRNLIQGE 712
                            ...::.:.||.               ::||.:.   .::::|.::  |.
Yeast   691 ----------------ASIESADILCP---------------LLESFIT---FSLDDWISI--GY 719

  Fly   713 ETPNEDDIYNIT-ITLKVL--SILYSSHNLNPWELFKSLFQDVEEAQSKENIDRCLPNEALVYCI 774
            ||    ::..|| .|:|..  |.:.:|.....:::|......:...:.||..::.|
Yeast   720 ET----ELKKITDKTIKAFMDSTIGNSKVDMKYDIFAKFIHHIHHFEKKELQEKFL--------- 771

  Fly   775 EACYFSISWGLQYVENECESVNVTEVVAELRNNLDTFMGACFE--LTRDGPTVQIQEAAYQSI-C 836
                           |:         :|.|:.:|..|:....:  .:||.         |:.: |
Yeast   772 ---------------NQ---------IATLKIHLKKFLQEKMDPNNSRDD---------YKDLTC 803

  Fly   837 DLLIIFSDKLARSEIEHIRGLEYKSRMDEHLI---LDNFVQHYVFSLKQDVAQDETRIEELHKKR 898
            .|..::.:||.      |.|.:|...:||.|:   |:|||.. :..:.||.  |::..:|::.|.
Yeast   804 SLYELYINKLT------ILGRDYPIEVDEELLQLFLNNFVSR-IPIMFQDF--DDSTAQEINFKM 859

  Fly   899 NFLACYCKLVVYNIIPTMRAASIFKYYVKCYNDYGDIIKATLGK-----AREINKVNFAMTLLLS 958
            ..|     |..:|:       ..::..::...||.:.|...|..     |..|.::|   ||::|
Yeast   860 LVL-----LATWNL-------EKWREIIEKVRDYENSISKDLRSVWKPIAAIIGRLN---TLVIS 909

  Fly   959 LITVFKSLQEQSEDGIVSKSS-QEFVDLKELAKRFALTFGFDAIKNRESVAA-----IHRGG--- 1014
            |....::.:..:....:..|: ...:|:....|.|.|....||...|.|::.     :|...
Yeast   910 LAATNETFENINSLFYLKWSACTSLMDIIVAIKIFELKLPADATTWRYSMSEQFPFYLHDNASKV 974

  Fly  1015 -----IY----FAANKEPDDPVR-----------APTRLLFLEVLNEFNYKLLKQDKKVIMSFLD 1059
                 :|    ||  |:.|..:.           .|....|..:..||....:|....:.::.||
Yeast   975 LLKIFLYLESLFA--KQVDVQLERVADEDANLNDLPETGFFENIETEFLLFTVKLKGLMKLNILD 1037

  Fly  1060 KIIPPAMPSSRAEEWQPLILYRNSLLHGETDQAPVASKRAYTRKRRDHDEEE--------EEEED 1116
            :.....:..:: |:..||.   ..::.....:.|..:|:...:.:.:..:.|        |.|.|
Yeast  1038 ERFASRVALNK-EKLGPLF---KKIVDDTIMENPEPNKKNIQKAKSNQTQREKAPLQPNSERETD 1098

  Fly  1117 --EEEHNDPD 1124
              ..|:||||
Yeast  1099 HANTENNDPD 1108

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SA	NP_477268.2	STAG	190..298	CDD:285686	35/140 (25%)
IRR1	NP_012238.1	IRR1	74..881	CDD:227824	195/997 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346410
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5537
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000572
OrthoInspector	1	1.000	-	-		oto99580
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11199
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3773
SonicParanoid	1	1.000	-	-		X570
TreeFam	0	0.000	Not matched by this tool.
	8	7.870