DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SA and stag2b

DIOPT Version :9

Sequence 1:	NP_477268.2	Gene:	SA / 33974	FlyBaseID:	FBgn0020616	Length:	1127	Species:	Drosophila melanogaster
Sequence 2:	XP_005173250.1	Gene:	stag2b / 560751	ZFINID:	ZDB-GENE-030131-2785	Length:	1276	Species:	Danio rerio

Alignment Length:	1089	Identity:	494/1089 - (45%)
Similarity:	700/1089 - (64%)	Gaps:	57/1089 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 DDDEDDFFAPIARKRKTPATRKGPTERKERVERPRKEPVDK--GHHERIDSEREITTDENSLYYI 120
            |.|:.|....|..|.|....:|||.|:.:.:.:    .|.:  |||:....|..:      |:.:
Zfish    26 DFDDPDGRNAIIGKGKAKKGKKGPGEKGKGMGK----GVGRMNGHHQENGMENVM------LFEV 80

  Fly   121 VRHSKNPIASIVDQWIEQYKANRETALVALMQFFINASGCKGKISEDIQYPVDHTSIIRRMTEEF 185
            ||..|:.:.|:||.|||.||.:|:.||:.|:.|||..|||||.:|.::...:.::.|||:|||||
Zfish    81 VRLGKSAMQSVVDDWIESYKHDRDVALLDLINFFIQCSGCKGVVSGEMFRNMQNSEIIRKMTEEF 145

  Fly   186 DEESGEYPLIMSGTQWRKFKNNFCDFVQTLVKQCQYSIIYDQFLMDNVISLLTGLSDSQVRAFRH 250
            ||:||:|||.|:|.||:|||::||:|:..||:|||||||||:::||.||||||||||||||||||
Zfish   146 DEDSGDYPLTMTGPQWKKFKSSFCEFIGVLVRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRH 210

  Fly   251 TATLAAMKLMTALVDVALLVSNNFDNAAKQFEAERVKSRDRRASDRLDSLMTKRSELEENMDEIK 315
            |:||||||||||||:|||.:|.|.||..:|:||||.|...:||:|||:.|:.||.||:||.|||:
Zfish   211 TSTLAAMKLMTALVNVALNLSINMDNTQRQYEAERNKMIGKRANDRLELLLQKRKELQENQDEIE 275

  Fly   316 SMLTYMFKSVFVHRYRDSLPDIRAICMAEIGIWMENYPQNFLDDSYLKYIGWTLHDKIGEVRLRC 380
            :|:..:||.||||||||::.:|||||:.|||:||:.|...||:||||||:|||:|||.|||||:|
Zfish   276 NMMNAIFKGVFVHRYRDAIAEIRAICIEEIGVWMKMYSDAFLNDSYLKYVGWTMHDKQGEVRLKC 340

  Fly   381 LQSLLPLYEKDELKGKLELFTSKFKDRIVAMTLDKEFEVSVHAVKLVISILKIHPEILADKDCEI 445
            |.:|..||...||..|||||||:||||||:||||||::|:|.|:||:..:|....|:|..:|||.
Zfish   341 LTALQGLYHNRELNAKLELFTSRFKDRIVSMTLDKEYDVAVQAIKLLTLVLHSSDEVLTAEDCES 405

  Fly   446 VYELVYSSHRGVAQAAAEFLNVRLF-HLTADMEETKTKRGKVRMPNTPLVRDLVQFFIESELHEH 509
            ||.||||:||.||.||.|||..:|| |...:.:....:||: :..|..|::..|.||:|||||||
Zfish   406 VYHLVYSAHRPVAVAAGEFLFKKLFSHRDPEDDSMPKRRGR-QSVNANLIKTTVFFFLESELHEH 469

  Fly   510 GAYLVDSFID-SNDMVRDWECMTDLLLEEPGPNEEVLDNKQESTLIEIMVSSVKQSATGEVPVGR 573
            .||||||..| :.::::|||||..|||:||.|.||.|.::||:.||||::.:::|:|....||||
Zfish   470 AAYLVDSMWDCAAELLKDWECMISLLLDEPLPGEEALTDRQETALIEILLCTIRQAAECHPPVGR 534

  Fly   574 ASNRKCTLSAKELKAIQDEKAKLTEHFIVTLPSLLEKYQADSEKLANLLAVPQYFDLNLYTTNRQ 638
            .:.:: .|:|||.|...|::.::||.|.:.||:||.||..|:||:.|||.:||:|||.:|||.|.
Zfish   535 GTGKR-VLTAKEKKTQLDDRTRMTELFAIALPALLAKYSVDAEKVTNLLQLPQFFDLEIYTTGRL 598

  Fly   639 EGNLQALLDRINQVMSMHTGREVLETCAKTLECLCAEGSATYTRCNIARSNIIESAVNKYKDAIE 703
            |.:|.:||.:|.:::..||..:|||.|:||...||.|....:.|.:||||.:::..|:|:...:|
Zfish   599 EKHLDSLLRQIREIVEKHTDTDVLEACSKTYHSLCNEEFTIFNRVDIARSQLLDEQVDKFNKLLE 663

  Fly   704 EWRNLIQGEETPNEDDIYNITITLKVLSILYSSHNLNPWELFKSLFQDVEEAQSKENIDRCLPNE 768
            ::   :|..|.|:|||.|.:..|||.:|..|::|:|:.|:||.|.::.:.  ...||.|  :|.:
Zfish   664 DF---LQEGEDPDEDDAYQVLSTLKRISAFYNAHDLSKWDLFTSNYKLLN--TGIENGD--MPEQ 721

  Fly   769 ALVYCIEACYFSISWGLQYVENECESVNVTEVVAELRNNLDTFMGACFELTRDGPTVQIQEAAYQ 833
            .:|:.::..::.|.|.|..|...|..   .|.:..||..:..|...|........|. ::|.|:.
Zfish   722 IVVHALQCTHYVILWSLAKVSEGCYK---KEDMLTLRKQMRAFCLMCQRYLTSVNTA-VKEQAFT 782

  Fly   834 SICDLLIIFSDKLARSEIEHIRGLEYKSRMDEHLILDNFVQHYVF------SLKQDVAQDET--R 890
            .:||||:|||.::.....|.:..|.|.........|.||:..:||      |...|..||:.  :
Zfish   783 ILCDLLLIFSHQIISGGREALEPLVYTPEASLQSELLNFILDHVFIDQDEDSNSTDGQQDDEAGK 847

  Fly   891 IEELHKKRNFLACYCKLVVYNIIPTMRAASIFKYYVKCYNDYGDIIKATLGKAREINKVNFAMTL 955
            ||.|||:||.||.||||::||::.....|.|||.|::.|||||||||.|:.|.|:|:|:..|.||
Zfish   848 IEALHKRRNLLAAYCKLIIYNVVEMSTGADIFKQYMRYYNDYGDIIKETMSKTRQIDKIQCAKTL 912

  Fly   956 LLSLITVFKSLQEQSEDG-IVSKSSQEFVDLKELAKRFALTFGFDAIKNRESVAAIHRGGIYFA- 1018
            :|||..:|..:  .||.| ...:||..|..:||||:||:||||.|.:|.||::|.:|:.||.||
Zfish   913 ILSLQQLFNEM--LSELGPSFDRSSSAFCGIKELARRFSLTFGLDQLKTREAIAMLHKDGIEFAF 975

  Fly  1019 --ANKEPDDPVRAPTRLLFLEVLNEFNYKLLKQDKKVIMSFLDKIIPPAMPSSRAEEWQPLILYR 1081
              ||.:.|.  ..|..|.||::|:||:.||::|||:.:..:|::.:...|...|.:.|.|||.||
Zfish   976 KEANPQGDG--HPPLNLAFLDILSEFSSKLMRQDKRTVHMYLERFMTFQMALQREDCWLPLISYR 1038

  Fly  1082 NSLLHGETDQ------------APVASKRA--YTRKRRDHDEEEEEEED 1116
            |||..|..|.            :.|.||:|  .|.||:..:||.....:
Zfish  1039 NSLQAGGDDDTMSVVSGISSRGSSVRSKKAKPATAKRKLPEEESSSSSE 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SA	NP_477268.2	STAG	190..298	CDD:285686	75/107 (70%)
stag2b	XP_005173250.1	STAG	150..258	CDD:312124	75/107 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595641
Domainoid	1	1.000	686	1.000	Domainoid score	I133
eggNOG	1	0.900	-	-		E1_COG5537
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	921	1.000	Inparanoid score	I351
OMA	1	1.010	-	-		QHG60131
OrthoDB	1	1.010	-	-		D167826at2759
OrthoFinder	1	1.000	-	-		FOG0000572
OrthoInspector	1	1.000	-	-		otm25349
orthoMCL	1	0.900	-	-		OOG6_101510
Panther	1	1.100	-	-	LDO	PTHR11199
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3773
SonicParanoid	1	1.000	-	-		X570
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800