DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SA and Stag3

DIOPT Version :9

Sequence 1:	NP_477268.2	Gene:	SA / 33974	FlyBaseID:	FBgn0020616	Length:	1127	Species:	Drosophila melanogaster
Sequence 2:	NP_058660.2	Gene:	Stag3 / 50878	MGIID:	1355311	Length:	1240	Species:	Mus musculus

Alignment Length:	1120	Identity:	428/1120 - (38%)
Similarity:	672/1120 - (60%)	Gaps:	75/1120 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 DALNESTSDADSPTKRMTRLRARGGVRDKPPIIDDDEDDFFAPIARKRKTPATRKGPTERKERVE 89
            |..::.|::.|||:...                |.|.:|......:||......|.....|.|.:
Mouse    46 DRDSQGTAEWDSPSTNE----------------DSDFEDSLRRNVKKRAAKQPPKAVPAAKHRKK 94

  Fly    90 RPRKEPVDKGHHERIDSEREITTDENSLYYIVRHSKNPIASIVDQWIEQYKANRETALVALMQFF 154
            :.|......|.:|.:.|       .|.|:..|:.:::.:.|:||:|::.||.:.....:.|:.||
Mouse    95 QSRIVSSGNGKNESVPS-------TNYLFDAVKAARSCMQSLVDEWLDNYKQDENAGFLELINFF 152

  Fly   155 INASGCKGKISEDIQYPVDHTSIIRRMTEEFDEESGEYPLIMSGTQWRKFKNNFCDFVQTLVKQC 219
            |.|.|||..::.::...:.::.||:.:||||:|:||:|||...|..|:||:.:||:||:|||.||
Mouse   153 IRACGCKSTVTPEMFKTMSNSEIIQHLTEEFNEDSGDYPLTAPGPSWKKFQGSFCEFVKTLVYQC 217

  Fly   220 QYSIIYDQFLMDNVISLLTGLSDSQVRAFRHTATLAAMKLMTALVDVALLVSNNFDNAAKQFEAE 284
            |||::||.|.||::||||.|||||||||||||:|||||||||:||.|||.:|.:.||..:|:|||
Mouse   218 QYSLLYDGFPMDDLISLLIGLSDSQVRAFRHTSTLAAMKLMTSLVKVALQLSLHKDNNQRQYEAE 282

  Fly   285 RVKSRDRRASDRLDSLMTKRSELEENMDEIKSMLTYMFKSVFVHRYRDSLPDIRAICMAEIGIWM 349
            |.|..::||.:||:||:.||.|.:||.::|:.|:..:|:.||||||||.||:|||||:.|||.||
Mouse   283 RNKGPEQRAPERLESLLEKRKEFQENQEDIEGMMNAIFRGVFVHRYRDILPEIRAICIEEIGYWM 347

  Fly   350 ENYPQNFLDDSYLKYIGWTLHDKIGEVRLRCLQSLLPLYEKDELKGKLELFTSKFKDRIVAMTLD 414
            ::|..:||:||||||||||||||..||||:|:::|..||...||..::||||::||||:|:|.:|
Mouse   348 QSYSTSFLNDSYLKYIGWTLHDKHKEVRLKCVKALAGLYSNQELSLRMELFTNRFKDRMVSMVMD 412

  Fly   415 KEFEVSVHAVKLVISILKIHPEILADKDCEIVYELVYSSHRGVAQAAAEFLNVRLFH------LT 473
            :|.||:|.|::|:..|||....:|...|||.:|.:||.|:|.:|.:|.||:..::||      ..
Mouse   413 RECEVAVEAIRLLTLILKNMEGVLTSADCEKIYSIVYISNRAMASSAGEFVYWKIFHPECGAKAV 477

  Fly   474 ADMEETKTKRGKVRMPNTPLVRDLVQFFIESELHEHGAYLVDSFID-SNDMVRDWECMTDLLLEE 537
            :|.|..::.:.:     ...:..|:.||:|||.|.|.||||||..| :...::|||.:|:|||::
Mouse   478 SDRERRRSPQAQ-----KTFIYLLLAFFMESEHHNHAAYLVDSLWDCAGSYLKDWESLTNLLLQK 537

  Fly   538 PGPNEEVLDNKQESTLIEIMVSSVKQSATGEVPVGRASNRKCTLSAKELKAIQDEKAKLTEHFIV 602
                ::.|.:.||..||||:|||.:|:|.|..||||.:.:| :|:|||.|....:|.||.||.|.
Mouse   538 ----DQNLGDMQERMLIEILVSSARQAAEGHPPVGRITGKK-SLTAKERKLQAYDKMKLAEHLIP 597

  Fly   603 TLPSLLEKYQADSEKLANLLAVPQYFDLNLYTTNRQEGNLQALLDRINQVMSMHTGREVLETCAK 667
            .||.||.|:.||:|.:|.||.:..||||::|.|.|.|.:|:.||.::.:|:..|...||||..|.
Mouse   598 LLPQLLAKFSADAENVAPLLQLLSYFDLSIYCTQRLEKHLELLLQQLQEVVVKHVEPEVLEAAAH 662

  Fly   668 TLECLCAEGSATYTRCNIARSNIIESAVNKYKDAIEEWRNLIQGEETPNEDDIYNITITLKVLSI 732
            .|..||......::|.:.|||.:::...::::..:::   |:|.... :||::|::|.|||.||.
Mouse   663 ALYLLCKPEFTFFSRVDFARSQLVDFLTDRFQQELDD---LMQSSFL-DEDEVYSLTATLKRLSA 723

  Fly   733 LYSSHNLNPWELFKSLFQDVEEAQSKENIDRCLPNEALVYCIEACYFSISWGLQYVENECESVNV 797
            .|::|:|..||:.:...:.:.:|.....:    |::.::..:...||||.|.:.::.   ||.:.
Mouse   724 FYNAHDLTRWEISEPCSRLLRKAVDTGEV----PHQVILPALTLVYFSILWTVTHIS---ESTSH 781

  Fly   798 TEVVAELRNNLDTFMGACFELTRD-GPTVQIQEAAYQSICDLLIIFSDKLARSEIEHIRGLEYKS 861
            .:::: |:..:..|...|.....| .|  :|||.|:..:.|||:|||.::.....:.:|.|.:..
Mouse   782 KQLMS-LKKRMVAFCELCQSCLSDVDP--EIQEQAFVLLSDLLLIFSPQMIVGGRDFLRPLVFFP 843

  Fly   862 RMDEHLILDNFVQHYVFSLKQDVA-----QDETRIEELHKKRNFLACYCKLVVYNIIPTMRAASI 921
            .......|.:|:..:||....::.     :|..:||.||::|..||.:|||::|.::....|:.:
Mouse   844 EATLQSELASFLMDHVFLQPGELGNGQSQEDHVQIELLHQRRRLLAGFCKLLLYGVLELDAASDV 908

  Fly   922 FKYYVKCYNDYGDIIKATLGKAREINKVNFAMTLLLSLITVFKSL-QEQSEDGIVSKSSQEFVDL 985
            ||:|.|.|.|||||||.||.:||:|::...:..|||||..::..| |||...|:....:  |:::
Mouse   909 FKHYNKFYEDYGDIIKETLTRARQIDRCQCSRILLLSLKQLYTELIQEQGPQGLTELPA--FIEM 971

  Fly   986 KELAKRFALTFGFDAIKNRESVAAIHRGGIYFAANK-EPDDPVRAPTRLLFLEVLNEFNYKLLKQ 1049
            ::||:||||:||...:.||:.|..:|:.||.|:.:: .|......|..|.|||:|:||:.:|..|
Mouse   972 RDLARRFALSFGPQQLHNRDLVVMLHKEGIKFSLSELPPAGSSHEPPNLAFLELLSEFSPRLFHQ 1036

  Fly  1050 DKKVIMSFLDKIIPPAMPSSRA--EEWQPLILYRNSLLHGE-TDQA-----PVASKRAYTRKRRD 1106
            ||::::|:|:|.:...   |:|  ..|.|:..|.:||...| |.:|     |.:.||......|.
Mouse  1037 DKRLLLSYLEKCLQRV---SKAPNHPWGPVTTYCHSLHPLEITAEASPRGPPHSKKRCVEGPCRP 1098

  Fly  1107 HDEEEEEEEDEEEHN 1121
            .:||...:|:..:.|
Mouse  1099 QEEESSSQEESLQLN 1113

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SA	NP_477268.2	STAG	190..298	CDD:285686	68/107 (64%)
Stag3	NP_058660.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..108		15/77 (19%)
		STAG	188..296	CDD:369917	68/107 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1077..1154		9/37 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1213..1240
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849833
Domainoid	1	1.000	678	1.000	Domainoid score	I141
eggNOG	1	0.900	-	-		E1_COG5537
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	902	1.000	Inparanoid score	I376
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60131
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000572
OrthoInspector	1	1.000	-	-		otm43338
orthoMCL	1	0.900	-	-		OOG6_101510
Panther	1	1.100	-	-	O	PTHR11199
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3773
SonicParanoid	1	1.000	-	-		X570
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.790