Protein Alignment SA1 and Stag2

DIOPT Version :10

• Sequence 1: NP_477268.2
• Gene: SA1 / 33974
• FlyBaseID: FBgn0020616
• Length: 1127
• Species: Drosophila melanogaster
• Sequence 2: NP_001277642.1
• Gene: Stag2 / 20843
• MGIID: 1098583
• Length: 1268
• Species: Mus musculus
• Alignment Length: 1062
• Identity: 492/1062 - (46%)
• Similarity: 699/1062 - (65%)
• Gaps: 59/1062 - (5%)

  Fly    78 RKGPTERKERVERPRKEPVD----KGHHERIDSEREITTDENSLYYIVRHSKNPIASIVDQWIEQ 138
            :|||.|:.:......|.|..    .|||::...|..:      |:.:|:..|:.:.|:||.|||.
Mouse    47 KKGPAEKGKSGNGGGKPPSGSNRMNGHHQQNGVENMM------LFEVVKMGKSAMQSVVDDWIES 105

  Fly   139 YKANRETALVALMQFFINASGCKGKISEDIQYPVDHTSIIRRMTEEFDEESGEYPLIMSGTQWRK 203
            ||.:|:.||:.|:.|||..|||||.::.::...:.::.|||:|||||||:||:|||.|:|.||:|
Mouse   106 YKHDRDIALLDLINFFIQCSGCKGVVTAEMFRHMQNSEIIRKMTEEFDEDSGDYPLTMAGPQWKK 170

  Fly   204 FKNNFCDFVQTLVKQCQYSIIYDQFLMDNVISLLTGLSDSQVRAFRHTATLAAMKLMTALVDVAL 268
            ||::||:|:..||:|||||||||:::||.|||||||||||||||||||:||||||||||||:|||
Mouse   171 FKSSFCEFIGVLVRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVAL 235

  Fly   269 LVSNNFDNAAKQFEAERVKSRDRRASDRLDSLMTKRSELEENMDEIKSMLTYMFKSVFVHRYRDS 333
            .:|.|.||..:|:||||.|...:||::||:.|:.||.||:||.|||::|:..:||.||||||||:
Mouse   236 NLSINMDNTQRQYEAERNKMIGKRANERLELLLQKRKELQENQDEIENMMNAIFKGVFVHRYRDA 300

  Fly   334 LPDIRAICMAEIGIWMENYPQNFLDDSYLKYIGWTLHDKIGEVRLRCLQSLLPLYEKDELKGKLE 398
            :.:|||||:.||||||:.|...||:||||||:|||:|||.|||||:||.:|..||...||..|||
Mouse   301 IAEIRAICIEEIGIWMKMYSDAFLNDSYLKYVGWTMHDKQGEVRLKCLTALQGLYYNKELNSKLE 365

  Fly   399 LFTSKFKDRIVAMTLDKEFEVSVHAVKLVISILKIHPEILADKDCEIVYELVYSSHRGVAQAAAE 463
            ||||:||||||:||||||::|:|.|:||:..:|:...|:|..:|||.||.||||:||.||.||.|
Mouse   366 LFTSRFKDRIVSMTLDKEYDVAVQAIKLLTLVLQSSEEVLTAEDCENVYHLVYSAHRPVAVAAGE 430

  Fly   464 FLNVRLFHLTADMEETKTKRGKVRMPNTPLVRDLVQFFIESELHEHGAYLVDSFID-SNDMVRDW 527
            ||..:||......|:...||...:.||..||:.||.||:|||||||.||||||..| :.::::||
Mouse   431 FLYKKLFSRRDPEEDGLMKRRGRQGPNANLVKTLVFFFLESELHEHAAYLVDSMWDCATELLKDW 495

  Fly   528 ECMTDLLLEEPGPNEEVLDNKQESTLIEIMVSSVKQSATGEVPVGRASNRKCTLSAKELKAIQDE 592
            |||..||||||...||.|.::|||.|||||:.:::|:|....||||.:.:: .|:|||.|...|:
Mouse   496 ECMNSLLLEEPLSGEEALTDRQESALIEIMLCTIRQAAECHPPVGRGTGKR-VLTAKEKKTQLDD 559

  Fly   593 KAKLTEHFIVTLPSLLEKYQADSEKLANLLAVPQYFDLNLYTTNRQEGNLQALLDRINQVMSMHT 657
            :.::||.|.|.||.||.||..|:||:.|||.:||||||.:|||.|.|.:|.|||.:|..::..||
Mouse   560 RTRITELFAVALPQLLAKYSVDAEKVTNLLQLPQYFDLEIYTTGRLEKHLDALLRQIRNIVEKHT 624

  Fly   658 GREVLETCAKTLECLCAEGSATYTRCNIARSNIIESAVNKYKDAIEEWRNLIQGEETPNEDDIYN 722
            ..:|||.|:||...||.|....:.|.:|:||.:|:...:|:...:|::  |.:||| |:|||.|.
Mouse   625 DTDVLEACSKTYHALCNEEFTIFNRVDISRSQLIDELADKFNRLLEDF--LQEGEE-PDEDDAYQ 686

  Fly   723 ITITLKVLSILYSSHNLNPWELFKSLFQDVEEAQSKENIDRCLPNEALVYCIEACYFSISWGLQY 787
            :..|||.::..:::|:|:.|:||...::.::  ...||.|  :|.:.:::.::..::.|.|.|..
Mouse   687 VLSTLKRITAFHNAHDLSKWDLFACNYKLLK--TGIENGD--MPEQIVIHALQCAHYVILWQLAK 747

  Fly   788 VENECESVNVTEVVAELRNNLDTFMGAC-FELTRDGPTVQIQEAAYQSICDLLIIFSDKLARSEI 851
            :   .||.:..|.:..|:..:..|...| ..||....||  :|.|:..:||:|:|||.::.....
Mouse   748 I---TESTSTKEDLLRLKKQMRVFCQICQHYLTNVNTTV--KEQAFTILCDILMIFSHQIMSGGR 807

  Fly   852 EHIRGLEY--KSRMDEHLILDNFVQHYVFSLKQD--------VAQDE-TRIEELHKKRNFLACYC 905
            :.:..|.|  .|.:...|:  :|:..:|| ::||        ..:|| ::||.|||:||.||.:|
Mouse   808 DMLEPLVYTPDSSLQSELL--SFILDHVF-IEQDDDSNSADGQQEDEASKIEALHKRRNLLAAFC 869

  Fly   906 KLVVYNIIPTMRAASIFKYYVKCYNDYGDIIKATLGKAREINKVNFAMTLLLSLITVFKSLQEQS 970
            ||:||.::....||.|||.|:|.|||||||||.|:.|.|:|:|:..|.||:|||..:|..:.:
Mouse   870 KLIVYTVVEMNTAADIFKQYMKYYNDYGDIIKETMSKTRQIDKIQCAKTLILSLQQLFNEMIQ-- 932

  Fly   971 EDGI-VSKSSQEFVDLKELAKRFALTFGFDAIKNRESVAAIHRGGIYFAANKEPDDPVRA--PTR 1032
            |:|. ..:||..|..:||||:|||||||.|.:|.||::|.:|:.||.||. |||:....:  |..
Mouse   933 ENGYNFDRSSSTFSGIKELARRFALTFGLDQLKTREAIAMLHKDGIEFAF-KEPNPQGESHPPLN 996

  Fly  1033 LLFLEVLNEFNYKLLKQDKKVIMSFLDKIIPPAMPSSRAEEWQPLILYRNSLLHGETDQ------ 1091
            |.||::|:||:.|||:|||:.:..:|:|.:...|...|.:.|.||:.||||||.|..|.
Mouse   997 LAFLDILSEFSSKLLRQDKRTVYVYLEKFMTFQMSLRREDVWLPLMSYRNSLLAGGDDDTMSVIS 1061

  Fly  1092 ------APVASKRA--YTRKRR 1105
                  :.|.||::  .|.||:
Mouse  1062 GMSSRGSTVRSKKSKPSTGKRK 1083

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SA1	NP_477268.2	IRR1	66..>426	CDD:227824	200/351 (57%)
		STAG	190..303	CDD:462502	76/112 (68%)
Stag2	NP_001277642.1	IRR1	102..>395	CDD:227824	186/292 (64%)
		STAG	157..270	CDD:462502	76/112 (68%)