DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SA and scc-3

DIOPT Version :9

Sequence 1:	NP_477268.2	Gene:	SA / 33974	FlyBaseID:	FBgn0020616	Length:	1127	Species:	Drosophila melanogaster
Sequence 2:	NP_506193.1	Gene:	scc-3 / 179749	WormBaseID:	WBGene00004738	Length:	1096	Species:	Caenorhabditis elegans

Alignment Length:	1130	Identity:	381/1130 - (33%)
Similarity:	615/1130 - (54%)	Gaps:	117/1130 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LNESTSDADSPTKRMTRLRARGGVRD---------KPPIIDDDEDDFFAPIARKRKTPATRKGPT 82
            ::|:.:| .||.:..||.:||....|         |.|:.              |...|:.:|..
Worm     1 MSETPTD-QSPQRMSTRNQARVNYTDMAAGNNSVEKEPVF--------------RSPTASTRGRK 50

  Fly    83 ERKERVE---------------------RPRKEPVDKGHHERIDSEREITTDENS------LYYI 120
            :|...|:                     |||...:......|....|..||:|::      |...
Worm    51 KRAANVDVADLSASFGNLNNFSTPPKRGRPRGGGLGSARGGRAPMVRRTTTEESAEVDDRELVAA 115

  Fly   121 VRHSKNPIASIVDQWIEQYKANRETALVALMQFFINASGCKGKISEDIQYPVDHTSIIRRMTEEF 185
            |:..|. |...||:||.:|......|:..:.|||....||||.::..:...:.:..||.||||:|
Worm   116 VKSGKK-ITEAVDRWIGRYNEKFLVAIAEMHQFFFAICGCKGIVTPQMSATLTYKDIICRMTEDF 179

  Fly   186 DEESGEYPLIMSGTQWRKFKNNFCDFVQTLVKQCQYSIIYDQFLMDNVISLLTGLSDSQVRAFRH 250
            :|:|.:|||:..|: .:|.:.|..:|:.||:.:.:.|:::|..|||..:.||||::|||||||||
Worm   180 EEDSADYPLVHGGS-LKKVRANLHNFIHTLIIRTKASMLFDSNLMDGFVQLLTGMADSQVRAFRH 243

  Fly   251 TATLAAMKLMTALVDVALLVSNNFDNAAKQFEAERVKSRDRRA-SDRLDSLMTKRSELEENMDEI 314
            |||..|||:.:|||||.:.::.:.:..:||.|||:.|.::..| :::.::|:.:|::.||..:||
Worm   244 TATFCAMKITSALVDVTIELTQSKEKTSKQIEAEKAKLKNNSAGNEKYEALVAQRTQTEERAEEI 308

  Fly   315 KSMLTYMFKSVFVHRYRDSLPDIRAICMAEIGIWMENYPQNFLDDSYLKYIGWTLHDKIGEVRLR 379
            :.::.|:|:|||||||||.:||||.||:.|:|.||:.||::|::|||||||||::.||:|:||.|
Worm   309 RQIIGYLFRSVFVHRYRDVVPDIRCICIQELGHWMDVYPEHFVEDSYLKYIGWSMFDKVGDVRQR 373

  Fly   380 CLQSLLPLYEKDELKGKLELFTSKFKDRIVAMTLDKEFEVSVHAVKLVISILKIHPEILADKDCE 444
            |:::|:||:||..:..|||||.:|||||:|:|.|||:.|.|:..|.|:..:..:.|.:|..||..
Worm   374 CIRALIPLFEKTLILDKLELFVNKFKDRLVSMLLDKDLETSIETVHLMRVLYTVFPTLLTIKDVV 438

  Fly   445 IVYELVYSSHRGVAQAAAEFLNVRLFHLTADMEETKTKRGKV-RMPNTPLVRDLVQFFIESELHE 508
            .:|||:|:|:|.:|.||..|||.::|       .:..|.||. ...|.|||:||..||||.:||:
Worm   439 PIYELIYASNRPLAVAAGMFLNTKVF-------RSAEKPGKAPTAANIPLVKDLTTFFIEGDLHQ 496

  Fly   509 HGAYLVDSFIDSNDMVRDWECMTDLLLEEPGPNEEVLDNKQESTLIEIMVSSVKQSATGEVPVGR 573
            |..||||:..:||.:|:||..|.:||:.:    :..||:..|:.||||:..||.||||||.||||
Worm   497 HATYLVDALFESNPIVKDWATMGELLIND----QYQLDSNFETKLIEILTCSVVQSATGEPPVGR 557

  Fly   574 ASNRKCTLSAKELKAIQDEKAKLTEHFIVTLPSLLEKYQADSEKLANLLAVPQYFDLNLYTTNRQ 638
            ...:|...||||.:.:.:::.:|||..|..:|.|:.|:.:|:||:.||:.:|.:|.|..|.:.|.
Worm   558 HIVKKGAPSAKESRDLVEDRQRLTETLIPLIPRLITKFSSDNEKIINLVNIPLHFQLETYLSARM 622

  Fly   639 EGNLQALLDRINQVMSMHTGREVLETCAKTLECLCAEGSATYTRCNIARSNIIESAVNKYKDAIE 703
            :.:|..|::.::.::..|...|:|:..|:....|....|.         |.::|....|..|.:.
Worm   623 QTHLMELMEGLDSLIEKHLDEELLKAVAELYYHLTTNSSI---------SALVEGHKMKLLDGVA 678

  Fly   704 EW-RNLIQ-------GEETPNEDDIYNITITLKVLSILYSSHNLNPWELFKSLFQDVEEAQSKEN 760
            .: |..:|       |||   |:.::  ...:|.::......:|..|:|:..|.:.|.. .::|:
Worm   679 AFIRKSMQQFDDDQMGEE---EEALF--VSYIKRMAAFAGFMDLRHWDLWDILLKVVSN-YTRED 737

  Fly   761 IDRCLPNEAL-VYCIEACYFSISWGLQYVENECESVNVTEVVAELRNNLDTFMGACFE-LTRDGP 823
            ..|.:...:: :..::.|:.|::     ::.|.|:....: |.:|:...|..:....| |..:..
Worm   738 TQRDVRERSMQMLFMQLCFDSMN-----IKKEGETPKADQ-VRKLKKRRDQLIRIVTETLNEEAC 796

  Fly   824 TVQIQEAAYQSICDLLIIFSDKLARSEIEHIRGLEYKSRMDEHLILDN---FVQHYVFSLK--QD 883
            .|   |.||..||||:|:|..:||    |..:.||......:.::|.|   |:...||.:.  .|
Worm   797 GV---EQAYLVICDLMILFGSQLA----EESKALEPLIWRPDAMVLGNLKIFLDVNVFDVSNLDD 854

  Fly   884 VAQDETRIEELHKKRNFLACYCKLVVYNIIPTMRAASIFKYYVKCYNDYGDIIKATLGKAREINK 948
            :.|.| :||.:||.|..:|.|.||:::..:|...|:.:.|.|...:.|:|||.|..|.|.|||:.
Worm   855 MDQQE-KIEVMHKMRQHVAQYAKLIIHGAMPVAEASHLIKRYQSHFQDFGDIFKNLLSKCREISF 918

  Fly   949 VNFAMTLLLSLITVFKSLQE-QSEDGIVSKSSQEFVDLKELAKRFALTFGFDAIKNRESVAAIHR 1012
            |...:.:..:|.|::..|.| |..|.:    |:.|..:::||||....||.|..|||.:::::|:
Worm   919 VETGVMICETLKTLYSQLDEDQGTDPL----SESFNSIRDLAKRLGPAFGVDYAKNRFAISSLHK 979

  Fly  1013 GGIYFAANKEPDDPVRAPTRLLFLEVLNEFNYKLLKQDKKVIMSFLDKIIPPAMPSSRAEEWQPL 1077
            ..|.||..:...:..:.|..:.|||:..||:.|||.|||..::.:|:||....:.:|.. .|:|.
Worm   980 KAIDFAFEEYDKENHQMPKNIFFLEIAIEFSGKLLAQDKMAVVRYLNKIYTNRVGTSTV-VWEPY 1043

  Fly  1078 ILYRNSLL-HGETDQAPVASKRAYT 1101
            .||..||. ..:.|...|.|....|
Worm  1044 RLYLGSLSDRNDDDNMSVRSGMTVT 1068

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SA	NP_477268.2	STAG	190..298	CDD:285686	45/108 (42%)
scc-3	NP_506193.1	STAG	184..286	CDD:285686	44/102 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167064
Domainoid	1	1.000	448	1.000	Domainoid score	I270
eggNOG	1	0.900	-	-		E1_COG5537
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	586	1.000	Inparanoid score	I544
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60131
OrthoDB	1	1.010	-	-		D167826at2759
OrthoFinder	1	1.000	-	-		FOG0000572
OrthoInspector	1	1.000	-	-		oto19051
orthoMCL	1	0.900	-	-		OOG6_101510
Panther	1	1.100	-	-	LDO	PTHR11199
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3773
SonicParanoid	1	1.000	-	-		X570
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.800