DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SA and STAG2

DIOPT Version :9

Sequence 1:	NP_477268.2	Gene:	SA / 33974	FlyBaseID:	FBgn0020616	Length:	1127	Species:	Drosophila melanogaster
Sequence 2:	NP_001036214.1	Gene:	STAG2 / 10735	HGNCID:	11355	Length:	1268	Species:	Homo sapiens

Alignment Length:	1053	Identity:	489/1053 - (46%)
Similarity:	698/1053 - (66%)	Gaps:	50/1053 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 RKGPTERKERVERPRKEPVD----KGHHERIDSEREITTDENSLYYIVRHSKNPIASIVDQWIEQ 138
            :|||.|:.:......|.|..    .|||::...|..:      |:.:|:..|:.:.|:||.|||.
Human    47 KKGPAEKGKGGNGGGKPPSGPNRMNGHHQQNGVENMM------LFEVVKMGKSAMQSVVDDWIES 105

  Fly   139 YKANRETALVALMQFFINASGCKGKISEDIQYPVDHTSIIRRMTEEFDEESGEYPLIMSGTQWRK 203
            ||.:|:.||:.|:.|||..|||||.::.::...:.::.|||:|||||||:||:|||.|:|.||:|
Human   106 YKHDRDIALLDLINFFIQCSGCKGVVTAEMFRHMQNSEIIRKMTEEFDEDSGDYPLTMAGPQWKK 170

  Fly   204 FKNNFCDFVQTLVKQCQYSIIYDQFLMDNVISLLTGLSDSQVRAFRHTATLAAMKLMTALVDVAL 268
            ||::||:|:..||:|||||||||:::||.|||||||||||||||||||:||||||||||||:|||
Human   171 FKSSFCEFIGVLVRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVAL 235

  Fly   269 LVSNNFDNAAKQFEAERVKSRDRRASDRLDSLMTKRSELEENMDEIKSMLTYMFKSVFVHRYRDS 333
            .:|.|.||..:|:||||.|...:||::||:.|:.||.||:||.|||::|:..:||.||||||||:
Human   236 NLSINMDNTQRQYEAERNKMIGKRANERLELLLQKRKELQENQDEIENMMNAIFKGVFVHRYRDA 300

  Fly   334 LPDIRAICMAEIGIWMENYPQNFLDDSYLKYIGWTLHDKIGEVRLRCLQSLLPLYEKDELKGKLE 398
            :.:|||||:.||||||:.|...||:||||||:|||:|||.|||||:||.:|..||...||..|||
Human   301 IAEIRAICIEEIGIWMKMYSDAFLNDSYLKYVGWTMHDKQGEVRLKCLTALQGLYYNKELNSKLE 365

  Fly   399 LFTSKFKDRIVAMTLDKEFEVSVHAVKLVISILKIHPEILADKDCEIVYELVYSSHRGVAQAAAE 463
            ||||:||||||:||||||::|:|.|:||:..:|:...|:|..:|||.||.||||:||.||.||.|
Human   366 LFTSRFKDRIVSMTLDKEYDVAVQAIKLLTLVLQSSEEVLTAEDCENVYHLVYSAHRPVAVAAGE 430

  Fly   464 FLNVRLFHLTADMEETKTKRGKVRMPNTPLVRDLVQFFIESELHEHGAYLVDSFID-SNDMVRDW 527
            ||..:||......|:...||...:.||..||:.||.||:|||||||.||||||..| :.::::||
Human   431 FLYKKLFSRRDPEEDGMMKRRGRQGPNANLVKTLVFFFLESELHEHAAYLVDSMWDCATELLKDW 495

  Fly   528 ECMTDLLLEEPGPNEEVLDNKQESTLIEIMVSSVKQSATGEVPVGRASNRKCTLSAKELKAIQDE 592
            |||..||||||...||.|.::|||.|||||:.:::|:|....||||.:.:: .|:|||.|...|:
Human   496 ECMNSLLLEEPLSGEEALTDRQESALIEIMLCTIRQAAECHPPVGRGTGKR-VLTAKEKKTQLDD 559

  Fly   593 KAKLTEHFIVTLPSLLEKYQADSEKLANLLAVPQYFDLNLYTTNRQEGNLQALLDRINQVMSMHT 657
            :.|:||.|.|.||.||.||..|:||:.|||.:||||||.:|||.|.|.:|.|||.:|..::..||
Human   560 RTKITELFAVALPQLLAKYSVDAEKVTNLLQLPQYFDLEIYTTGRLEKHLDALLRQIRNIVEKHT 624

  Fly   658 GREVLETCAKTLECLCAEGSATYTRCNIARSNIIESAVNKYKDAIEEWRNLIQGEETPNEDDIYN 722
            ..:|||.|:||...||.|....:.|.:|:||.:|:...:|:...:|::  |.:||| |:|||.|.
Human   625 DTDVLEACSKTYHALCNEEFTIFNRVDISRSQLIDELADKFNRLLEDF--LQEGEE-PDEDDAYQ 686

  Fly   723 ITITLKVLSILYSSHNLNPWELFKSLFQDVEEAQSKENIDRCLPNEALVYCIEACYFSISWGLQY 787
            :..|||.::..:::|:|:.|:||...::.::  ...||.|  :|.:.:::.::..::.|.|.|..
Human   687 VLSTLKRITAFHNAHDLSKWDLFACNYKLLK--TGIENGD--MPEQIVIHALQCTHYVILWQLAK 747

  Fly   788 VENECESVNVTEVVAELRNNLDTFMGAC-FELTRDGPTVQIQEAAYQSICDLLIIFSDKLARSEI 851
            :   .||.:..|.:..|:..:..|...| ..||....||  :|.|:..:||:|:|||.::.....
Human   748 I---TESSSTKEDLLRLKKQMRVFCQICQHYLTNVNTTV--KEQAFTILCDILMIFSHQIMSGGR 807

  Fly   852 EHIRGLEY--KSRMDEHLILDNFVQHYVFSLKQD--------VAQDE-TRIEELHKKRNFLACYC 905
            :.:..|.|  .|.:...|:  :|:..:|| ::||        ..:|| ::||.|||:||.||.:|
Human   808 DMLEPLVYTPDSSLQSELL--SFILDHVF-IEQDDDNNSADGQQEDEASKIEALHKRRNLLAAFC 869

  Fly   906 KLVVYNIIPTMRAASIFKYYVKCYNDYGDIIKATLGKAREINKVNFAMTLLLSLITVFKSLQEQS 970
            ||:||.::....||.|||.|:|.|||||||||.|:.|.|:|:|:..|.||:|||..:|..:.:
Human   870 KLIVYTVVEMNTAADIFKQYMKYYNDYGDIIKETMSKTRQIDKIQCAKTLILSLQQLFNEMIQ-- 932

  Fly   971 EDGI-VSKSSQEFVDLKELAKRFALTFGFDAIKNRESVAAIHRGGIYFAANKEPDDPVRA--PTR 1032
            |:|. ..:||..|..:||||:|||||||.|.:|.||::|.:|:.||.||. |||:....:  |..
Human   933 ENGYNFDRSSSTFSGIKELARRFALTFGLDQLKTREAIAMLHKDGIEFAF-KEPNPQGESHPPLN 996

  Fly  1033 LLFLEVLNEFNYKLLKQDKKVIMSFLDKIIPPAMPSSRAEEWQPLILYRNSLLHGETDQ-----A 1092
            |.||::|:||:.|||:|||:.:..:|:|.:...|...|.:.|.||:.||||||.|..|.     :
Human   997 LAFLDILSEFSSKLLRQDKRTVYVYLEKFMTFQMSLRREDVWLPLMSYRNSLLAGGDDDTMSVIS 1061

  Fly  1093 PVASKRAYTRKRR 1105
            .::|:.:..|.::
Human  1062 GISSRGSTVRSKK 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SA	NP_477268.2	STAG	190..298	CDD:285686	74/107 (69%)
STAG2	NP_001036214.1	STAG	157..265	CDD:400698	74/107 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159466
Domainoid	1	1.000	678	1.000	Domainoid score	I139
eggNOG	1	0.900	-	-		E1_COG5537
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	904	1.000	Inparanoid score	I377
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60131
OrthoDB	1	1.010	-	-		D167826at2759
OrthoFinder	1	1.000	-	-		FOG0000572
OrthoInspector	1	1.000	-	-		otm41283
orthoMCL	1	0.900	-	-		OOG6_101510
Panther	1	1.100	-	-	LDO	PTHR11199
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X570
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770