DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SA and STAG3

DIOPT Version :9

Sequence 1:	NP_477268.2	Gene:	SA / 33974	FlyBaseID:	FBgn0020616	Length:	1127	Species:	Drosophila melanogaster
Sequence 2:	XP_016867172.1	Gene:	STAG3 / 10734	HGNCID:	11356	Length:	1239	Species:	Homo sapiens

Alignment Length:	1152	Identity:	451/1152 - (39%)
Similarity:	687/1152 - (59%)	Gaps:	92/1152 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 STSDADSPTKRMTRLRARGGVRDKPPIIDDDEDDFFAPIARKRKTPATRKGPTERKERVERPRKE 94
            |:|.|..|...........|..|.  ::.|::.||...:.|..|..|.:: |.:.....:.|:|.
Human    20 SSSSASLPFDDRDSNHTSEGNGDS--LLADEDTDFEDSLNRNVKKRAAKR-PPKTTPVAKHPKKG 81

  Fly    95 PVDKGHHERIDSEREITTDENSLYYIVRHSKNPIASIVDQWIEQYKANRETALVALMQFFINASG 159
            ......|.|..||    ...|.|:..|:.:|:.:.|:||:|::.||.:::...:.|:.|||.:.|
Human    82 SRVVHRHSRKQSE----PPANDLFNAVKAAKSDMQSLVDEWLDSYKQDQDAGFLELVNFFIQSCG 142

  Fly   160 CKGKISEDIQYPVDHTSIIRRMTEEFDEESGEYPLIMSGTQWRKFKNNFCDFVQTLVKQCQYSII 224
            |||.::.::...:.::.||:.:||:|:|:||:||||..|..|:||:.:||:||:|||.|||||::
Human   143 CKGIVTPEMFKKMSNSEIIQHLTEQFNEDSGDYPLIAPGPSWKKFQGSFCEFVRTLVCQCQYSLL 207

  Fly   225 YDQFLMDNVISLLTGLSDSQVRAFRHTATLAAMKLMTALVDVALLVSNNFDNAAKQFEAERVKSR 289
            ||.|.||::||||||||||||||||||:|||||||||:||.|||.:|.:.||..:|:||||.|..
Human   208 YDGFPMDDLISLLTGLSDSQVRAFRHTSTLAAMKLMTSLVKVALQLSVHQDNNQRQYEAERNKGP 272

  Fly   290 DRRASDRLDSLMTKRSELEENMDEIKSMLTYMFKSVFVHRYRDSLPDIRAICMAEIGIWMENYPQ 354
            .:||.:||:||:.||.||:|:.:||:.|:..:|:.||||||||.||:|||||:.|||.||::|..
Human   273 GQRAPERLESLLEKRKELQEHQEEIEGMMNALFRGVFVHRYRDVLPEIRAICIEEIGCWMQSYST 337

  Fly   355 NFLDDSYLKYIGWTLHDKIGEVRLRCLQSLLPLYEKDELKGKLELFTSKFKDRIVAMTLDKEFEV 419
            :||.||||||||||||||..||||:|:::|..||...:|..:||||||:||||:|:|.:|:|::|
Human   338 SFLTDSYLKYIGWTLHDKHREVRLKCVKALKGLYGNRDLTTRLELFTSRFKDRMVSMVMDREYDV 402

  Fly   420 SVHAVKLVISILKIHPEILADKDCEIVYELVYSSHRGVAQAAAEFLNVRLFHLTADM-----EET 479
            :|.||:|:|.|||....:|.|.|||.||.:||:||||:|.||.|||..:||:...::     .|.
Human   403 AVEAVRLLILILKNMEGVLTDADCESVYPVVYASHRGLASAAGEFLYWKLFYPECEIRMMGGREQ 467

  Fly   480 KTKRGKVRMPNTPLVRDLVQFFIESELHEHGAYLVDSFID-SNDMVRDWECMTDLLLEEPGPNEE 543
            :...|..|    ...:.|:.||:|||||:|.||||||..| :...::|||.:|.||||:    ::
Human   468 RQSPGAQR----TFFQLLLSFFVESELHDHAAYLVDSLWDCAGARLKDWEGLTSLLLEK----DQ 524

  Fly   544 VLDNKQESTLIEIMVSSVKQSATGEVPVGRASNRKCTLSAKELKAIQDEKAKLTEHFIVTLPSLL 608
            .|.:.||||||||:|||.:|::.|..||||.:.|| .|::||.|...|::.|||||.|..||.||
Human   525 NLGDVQESTLIEILVSSARQASEGHPPVGRVTGRK-GLTSKERKTQADDRVKLTEHLIPLLPQLL 588

  Fly   609 EKYQADSEKLANLLAVPQYFDLNLYTTNRQEGNLQALLDRINQVMSMHTGREVLETCAKTLECLC 673
            .|:.||:||:..||.:...|||::|.|.|.|.:|:..|.::.:|:..|....|||..|..|..||
Human   589 AKFSADAEKVTPLLQLLSCFDLHIYCTGRLEKHLELFLQQLQEVVVKHAEPAVLEAGAHALYLLC 653

  Fly   674 AEGSATYTRCNIARSNIIESAVNKYKDAIEEWRNLIQGEETPNEDDIYNITITLKVLSILYSSHN 738
            ......::|.:.|||.:::...::::..:||   |:|.... :||::||:..|||.||..|::|:
Human   654 NPEFTFFSRADFARSQLVDLLTDRFQQELEE---LLQSSFL-DEDEVYNLAATLKRLSAFYNTHD 714

  Fly   739 LNPWELFKSLFQDVEEAQSKENIDRCLPNEALVYCIEACYFSISWGLQYVENECESVNVTEVVAE 803
            |..|||::...|.:::|.....:    |::.::..:...||||.|.|.::.....|   .:.::.
Human   715 LTRWELYEPCCQLLQKAVDTGEV----PHQVILPALTLVYFSILWTLTHISKSDAS---QKQLSS 772

  Fly   804 LRNNLDTFMGACFELTRDGPTVQIQEAAYQSICDLLIIFSDKLARSEIEHIRGLEYKSRMDEHLI 868
            ||:.:..|...|.....|..| :|||.|:..:.|||:|||.::.....:.:|.|.:.........
Human   773 LRDRMVAFCELCQSCLSDVDT-EIQEQAFVLLSDLLLIFSPQMIVGGRDFLRPLVFFPEATLQSE 836

  Fly   869 LDNFVQHYVFSLKQDVA-----QDETRIEELHKKRNFLACYCKLVVYNIIPTMRAASIFKYYVKC 928
            |.:|:..:||....|:.     :|..:||.||::|..||.:|||::|.::....|:.:||:|.|.
Human   837 LASFLMDHVFIQPGDLGSGDSQEDHLQIERLHQRRRLLAGFCKLLLYGVLEMDAASDVFKHYNKF 901

  Fly   929 YNDYGDIIKATLGKAREINKVNFAMTLLLSLITVF-KSLQEQSEDGIVSKSSQEFVDLKELAKRF 992
            |||||||||.||.:||:|::.:.:..|||||..:: :.|||....|:  .....|:::::||:||
Human   902 YNDYGDIIKETLTRARQIDRSHCSRILLLSLKQLYTELLQEHGPQGL--NELPAFIEMRDLARRF 964

  Fly   993 ALTFGFDAIKNRESVAAIHRGGIYFAANK-EPDDPVRAPTRLLFLEVLNEFNYKLLKQDKKVIMS 1056
            ||:||...::||:.|..:|:.||.|:.:: .|......|..|.|||:|:||:.:|..|||::::|
Human   965 ALSFGPQQLQNRDLVVMLHKEGIQFSLSELPPAGSSNQPPNLAFLELLSEFSPRLFHQDKQLLLS 1029

  Fly  1057 FLDKII-----PPAMPSSRAEEWQPLILYRNSLLHGE-----TDQAPVASKRAYTR-----KRRD 1106
            :|:|.:     .|..|      |.|:..|.:||...|     :.|...:|||....     .|.|
Human  1030 YLEKCLQHVSQAPGHP------WGPVTTYCHSLSPVENTAETSPQVLPSSKRRRVEGPAKPNRED 1088

  Fly  1107 HDEEEEE----------------------------EEDEEEHNDPDY 1125
            ....:||                            |.:||:.::.|:
Human  1089 VSSSQEESLQLNSIPPTPTLTSTAVKSRQPLWGLKEMEEEDGSELDF 1135

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SA	NP_477268.2	STAG	190..298	CDD:285686	70/107 (65%)
STAG3	XP_016867172.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159464
Domainoid	1	1.000	678	1.000	Domainoid score	I139
eggNOG	1	0.900	-	-		E1_COG5537
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	904	1.000	Inparanoid score	I377
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60131
OrthoDB	1	1.010	-	-		D167826at2759
OrthoFinder	1	1.000	-	-		FOG0000572
OrthoInspector	1	1.000	-	-		otm41283
orthoMCL	1	0.900	-	-		OOG6_101510
Panther	1	1.100	-	-	O	PTHR11199
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3773
SonicParanoid	1	1.000	-	-		X570
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800