Protein Alignment SA and STAG1

DIOPT Version :9

• Sequence 1: NP_477268.2
• Gene: SA / 33974
• FlyBaseID: FBgn0020616
• Length: 1127
• Species: Drosophila melanogaster
• Sequence 2: NP_005853.2
• Gene: STAG1 / 10274
• HGNCID: 11354
• Length: 1258
• Species: Homo sapiens
• Alignment Length: 1186
• Identity: 521/1186 - (43%)
• Similarity: 736/1186 - (62%)
• Gaps: 135/1186 - (11%)

  Fly    25 DALNESTSDADSPTK------RMTRLRARGGVRDKPPIIDDDEDDFFAPIARKRKTPATRKGPTE 83
            |:.||:|:.:|:.::      :..|.|.|.|   :||              ...|.|  ||.|.|
Human    11 DSTNETTAHSDAGSELEETEVKGKRKRGRPG---RPP--------------STNKKP--RKSPGE 56

  Fly    84 RKERVE---------RPRKEPVDKGHHERIDSEREITTDENSLYYIVRHSKNPIASIVDQWIEQY 139
             |.|:|         |....|...|..|.:           :|:.:|:..|:.:.|:||.|||.|
Human    57 -KSRIEAGIRGAGRGRANGHPQQNGEGEPV-----------TLFEVVKLGKSAMQSVVDDWIESY 109

  Fly   140 KANRETALVALMQFFINASGCKGKISEDIQYPVDHTSIIRRMTEEFDEESGEYPLIMSGTQWRKF 204
            |.:|:.||:.|:.|||..|||:|.:..::...:.:..|||:|||||||:||:|||.|.|.||:||
Human   110 KQDRDIALLDLINFFIQCSGCRGTVRIEMFRNMQNAEIIRKMTEEFDEDSGDYPLTMPGPQWKKF 174

  Fly   205 KNNFCDFVQTLVKQCQYSIIYDQFLMDNVISLLTGLSDSQVRAFRHTATLAAMKLMTALVDVALL 269
            ::|||:|:..|::|||||||||:::||.|||||||||||||||||||:||||||||||||:|||.
Human   175 RSNFCEFIGVLIRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALN 239

  Fly   270 VSNNFDNAAKQFEAERVKSRDRRASDRLDSLMTKRSELEENMDEIKSMLTYMFKSVFVHRYRDSL 334
            :|.:.||..:|:||||.|...:||::||:.|:.||.||:||.|||::|:..:||.:|||||||::
Human   240 LSIHQDNTQRQYEAERNKMIGKRANERLELLLQKRKELQENQDEIENMMNSIFKGIFVHRYRDAI 304

  Fly   335 PDIRAICMAEIGIWMENYPQNFLDDSYLKYIGWTLHDKIGEVRLRCLQSLLPLYEKDELKGKLEL 399
            .:|||||:.|||:||:.|...||:||||||:||||||:.|||||:||::|..||...||..||||
Human   305 AEIRAICIEEIGVWMKMYSDAFLNDSYLKYVGWTLHDRQGEVRLKCLKALQSLYTNRELFPKLEL 369

  Fly   400 FTSKFKDRIVAMTLDKEFEVSVHAVKLVISILKIHPEILADKDCEIVYELVYSSHRGVAQAAAEF 464
            ||::||||||:||||||::|:|.|::||..||....|.|:::|||.||.||||:||.||.||.||
Human   370 FTNRFKDRIVSMTLDKEYDVAVEAIRLVTLILHGSEEALSNEDCENVYHLVYSAHRPVAVAAGEF 434

  Fly   465 LNVRLF--HLTADMEETKTKRGKVRMPNTPLVRDLVQFFIESELHEHGAYLVDSFIDSN-DMVRD 526
            |:.:||  | ....||...||.....||..|:|.||.||:|||||||.||||||..:|: ::::|
Human   435 LHKKLFSRH-DPQAEEALAKRRGRNSPNGNLIRMLVLFFLESELHEHAAYLVDSLWESSQELLKD 498

  Fly   527 WECMTDLLLEEPGPNEEVLDNKQESTLIEIMVSSVKQSATGEVPVGRASNRKCTLSAKELKAIQD 591
            |||||:||||||...||.:.::|||.|||:||.:::|:|....||||.:.:: .|:|||.|...|
Human   499 WECMTELLLEEPVQGEEAMSDRQESALIELMVCTIRQAAEAHPPVGRGTGKR-VLTAKERKTQID 562

  Fly   592 EKAKLTEHFIVTLPSLLEKYQADSEKLANLLAVPQYFDLNLYTTNRQEGNLQALLDRINQVMSMH 656
            ::.|||||||:|||.||.||.||:||:||||.:||||||.:|:|.|.|.:|.|||.:|..|:..|
Human   563 DRNKLTEHFIITLPMLLSKYSADAEKVANLLQIPQYFDLEIYSTGRMEKHLDALLKQIKFVVEKH 627

  Fly   657 TGREVLETCAKTLECLCAEGSATYTRCNIARSNIIESAVNKYKDAIEEWRNLIQGEETPNEDDIY 721
            ...:|||.|:||...||:|......|.:||||.:|:..|:::..::|:   |:|..|..::||||
Human   628 VESDVLEACSKTYSILCSEEYTIQNRVDIARSQLIDEFVDRFNHSVED---LLQEGEEADDDDIY 689

  Fly   722 NITITLKVLSILYSSHNLNPWELFKSLFQDVEEAQSKENIDR-CLPNEALVYCIEACYFSISWGL 785
            |:..|||.|:..:::|:|..|:||.:.::.:     |..|:. .:|.:.:|..::..::||.|.|
Human   690 NVLSTLKRLTSFHNAHDLTKWDLFGNCYRLL-----KTGIEHGAMPEQIVVQALQCSHYSILWQL 749

  Fly   786 QYVENECESVNVTEVVAELRNNLDTFMGACFELTRDGPTVQIQEAAYQSICDLLIIFSDKLARSE 850
            ..:.:...|   .|.:..||..:.:|:..|.:...:..| .::|.|:..:||||:|||.:|....
Human   750 VKITDGSPS---KEDLLVLRKTVKSFLAVCQQCLSNVNT-PVKEQAFMLLCDLLMIFSHQLMTGG 810

  Fly   851 IEHIRGLEYKSRMDEHLILDNFVQHYVF--------SLKQDVAQDETRIEELHKKRNFLACYCKL 907
            .|.::.|.:.........|.:||..:||        |::.|...:..:||.|||:||.||.:.||
Human   811 REGLQPLVFNPDTGLQSELLSFVMDHVFIDQDEENQSMEGDEEDEANKIEALHKRRNLLAAFSKL 875

  Fly   908 VVYNIIPTMRAASIFKYYVKCYNDYGDIIKATLGKAREINKVNFAMTLLLSLITVFKSL-QEQSE 971
            ::|:|:....||.|||:|:|.|||||||||.||.|.|:|:|:..|.||:|||..:|..| |||..
Human   876 IIYDIVDMHAAADIFKHYMKYYNDYGDIIKETLSKTRQIDKIQCAKTLILSLQQLFNELVQEQGP 940

  Fly   972 DGIVSKSSQEFVDLKELAKRFALTFGFDAIKNRESVAAIHRGGIYFA----ANKEPDDPVRAPTR 1032
            :  :.::|.....:||||:|||||||.|.||.||:||.:|:.||.||    ..|..:.|   |..
Human   941 N--LDRTSAHVSGIKELARRFALTFGLDQIKTREAVATLHKDGIEFAFKYQNQKGQEYP---PPN 1000

  Fly  1033 LLFLEVLNEFNYKLLKQDKKVIMSFLDKIIPPAMPSSRAEEWQPLILYRNSLL-HGETDQAPV-- 1094
            |.|||||:||:.|||:||||.:.|:|:|.:...|...|.:.|.|||.|||||: .||.|:..|
Human  1001 LAFLEVLSEFSSKLLRQDKKTVHSYLEKFLTEQMMERREDVWLPLISYRNSLVTGGEDDRMSVNS 1065

  Fly  1095 ---ASKRAYTR---------KRRDHDEE------------------------------------- 1110
               :||.:..|         |:|..||.
Human  1066 GSSSSKTSSVRNKKGRPPLHKKRVEDESLDNTWLNRTDTMIQTPGPLPAPQLTSTVLRENSRPMG 1130

  Fly  1111 EEEEEDEEEH-NDPDY 1125
            ::.:|.|.|| ::||:
Human  1131 DQIQEPESEHGSEPDF 1146

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SA	NP_477268.2	STAG	190..298	CDD:285686	72/107 (67%)
STAG1	NP_005853.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..84		23/92 (25%)
		RFX5_DNA_bdg	3..>83	CDD:405326	23/91 (25%)
		STAG	160..268	CDD:400698	72/107 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1055..1096		11/40 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1129..1148		6/18 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159462
Domainoid	1	1.000	678	1.000	Domainoid score	I139
eggNOG	1	0.900	-	-		E1_COG5537
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21191
Inparanoid	1	1.050	904	1.000	Inparanoid score	I377
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60131
OrthoDB	1	1.010	-	-		D167826at2759
OrthoFinder	1	1.000	-	-		FOG0000572
OrthoInspector	1	1.000	-	-		otm41283
orthoMCL	1	0.900	-	-		OOG6_101510
Panther	1	1.100	-	-	O	PTHR11199
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X570
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770