Protein Alignment Gas41 and YEATS4

DIOPT Version :9

• Sequence 1: NP_609086.1
• Gene: Gas41 / 33973
• FlyBaseID: FBgn0031873
• Length: 227
• Species: Drosophila melanogaster
• Sequence 2: NP_006521.1
• Gene: YEATS4 / 8089
• HGNCID: 24859
• Length: 227
• Species: Homo sapiens
• Alignment Length: 224
• Identity: 134/224 - (59%)
• Similarity: 166/224 - (74%)
• Gaps: 8/224 - (3%)

  Fly     1 MTDFGGDSGGRLKGVTIVKPIVYGNIARSFGKKREEDGHTHQWKVYLKPYFNEDMSIYVKKVHFK 65
            |.:||.|||||:|||||||||||||:||.||||||||||||||.||:|||.|||||.||||:.||
Human     5 MAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEDMSAYVKKIQFK 69

  Fly    66 LHESYANPNRIVVKPPYEITETGWGEFEVIIKIYFNDQSERPVTCYHILKLFQSPVVDGELSSST 130
            |||||.||.|:|.|||||||||||||||:||||:|.|.:|||||.||:|||||        |.:.
Human    70 LHESYGNPLRVVTKPPYEITETGWGEFEIIIKIFFIDPNERPVTLYHLLKLFQ--------SDTN 126

  Fly   131 TMDTKKGLVSESYEEIVFQEPTQILQHYLLLSEQSANGLLTHDTDFEEKKTKTLDNIVNVKQKVK 195
            .|..||.:|||.|:|::||:||.::|..|..|.|...|...|:|:|.|.:.||.:.:...|:|..
Human   127 AMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKKKTS 191

  Fly   196 GEIVTLKDKLKLARETISKFKAELAKVQK 224
            .||..||::||.:||||:..|.|:.|:::
Human   192 FEIAELKERLKASRETINCLKNEIRKLEE 220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gas41	NP_609086.1	YEATS	40..119	CDD:281374	61/78 (78%)
YEATS4	NP_006521.1	YEATS_GAS41_like	19..155	CDD:341128	99/143 (69%)
		Diacetylated histone H3 binding. /evidence=ECO:0000269|PubMed:29900004, ECO:0000269|PubMed:30071723, ECO:0007744|PDB:5VNB, ECO:0007744|PDB:5XTZ	93..97		3/3 (100%)
		Interaction with MLLT10. /evidence=ECO:0000269|PubMed:11756182	163..227		22/58 (38%)
		Interaction with TACC1. /evidence=ECO:0000269|PubMed:11903063	168..227		21/53 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	141	1.000	Domainoid score	I4736
eggNOG	1	0.900	-	-		E1_COG5033
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4760
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2981
Isobase	1	0.950	-	0	Normalized mean entropy	S932
OMA	1	1.010	-	-		QHG52998
OrthoDB	1	1.010	-	-		D1482359at2759
OrthoFinder	1	1.000	-	-		FOG0003954
OrthoInspector	1	1.000	-	-		oto91675
orthoMCL	1	0.900	-	-		OOG6_102192
Panther	1	1.100	-	-	LDO	PTHR23195
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2721
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.830