DRSC/TRiP Functional Genomics Resources

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Protein Alignment ihog and ROBO3

DIOPT Version :10

Sequence 1:NP_609085.1 Gene:ihog / 33972 FlyBaseID:FBgn0031872 Length:886 Species:Drosophila melanogaster
Sequence 2:NP_071765.2 Gene:ROBO3 / 64221 HGNCID:13433 Length:1386 Species:Homo sapiens


Alignment Length:795 Identity:175/795 - (22%)
Similarity:282/795 - (35%) Gaps:196/795 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 TLLTSSLLLFSL---LTSRLEAIPVLEKSPAHPAHSAHPAHPAHPA------HPAHPSPGVRILR 57
            |||..:|...||   :::..|.:.....|.|...|:..|  |..|:      .|....|  ||:.
Human     8 TLLQMNLFADSLAGDISNSSELLLGFNSSLAALNHTLLP--PGDPSLNGSRVGPEDAMP--RIVE 68

  Fly    58 APESLVAPLGDEVVLECETSLQPERFEWSHRSSRSPGAGFKYLKTGTAKANVSQEAAISRL---- 118
            .|..|:...|:...|.|             |:...|....::.|.|...|.|.::....||    
Human    69 QPPDLLVSRGEPATLPC-------------RAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPS 120

  Fly   119 ------RVL----VRPDTLGEYRCV--GWFGPLVVTSTIARLELASTSLVDAQESESPLQWRVSA 171
                  |::    .|||. |.|.||  .:.|  ...|..|.||:|   ::.....:||....|:.
Human   121 GALFFPRIVHGRRARPDE-GVYTCVARNYLG--AAASRNASLEVA---VLRDDFRQSPGNVVVAV 179

  Fly   172 GNSVLWSC-GQQVQSNPSASWSYYRNGVEIKPE---FIGTNGNLFLSNVSSESSGSYSCQATNPA 232
            |...:..| ..:....||.||.  ::|..:|.|   .....|.|.:|:.....:|.|.|.|:|.|
Human   180 GEPAVLECVPPRGHPEPSVSWR--KDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMA 242

  Fly   233 SGERIQLPGSLQLQVTPEQRSESKSPHLLRGQPSSQEITIREGSSLLLLCPGVGSPPPTVVWSSP 297
             |||    .|...:|...:|     |..|| :|.:|  .:...:.:..||...|.|||.:.|...
Human   243 -GER----ESAAAEVMVLER-----PSFLR-RPVNQ--VVLADAPVTFLCEVKGDPPPRLRWRKE 294

  Fly   298 DVVGAVKNKRSKV-FGHALEISNTRVNDAGTYICFQDNGV-RPALEHYIKVHVEQPPQIVRPPWA 360
            |  |.:...|.:: ..|:|.|.:....|.|||.|..:|.| |......:.|||  |||:|..|..
Human   295 D--GELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHV--PPQLVTQPQD 355

  Fly   361 DLTNEGDRLKLECKATGVPTPEIYWLLNGHSSI--DDSEAELSNNF-------LILHSVLKRHAG 416
            .:...|:.:..:|:..|.|.|.|:|...|...:  .....:.:..|       |.:.:|.:..||
Human   356 QMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAG 420

  Fly   417 YVQCFARNRLGEHSAGTLLQVN--------PKQIQEPRES----GG--------THRPKPN---- 457
            |..|.|.:..|...|..||::.        |..:|.|...    |.        |..|:|:    
Human   421 YYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWK 485

  Fly   458 ------QGS------------------------------------------RQKQMY-----PPT 469
                  ||.                                          :.::.:     |||
Human   486 KDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPT 550

  Fly   470 PPN----------VTRLSDESVMLRWMVPRNDGLPIVIFKVQYRMVGKRKNWQTTNDNIPYGKPK 524
            .|:          ||.::..|:.|.|......|..:..:.::.........|:|..|.:      
Human   551 EPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVIEAFSPAAGNTWRTVADGV------ 609

  Fly   525 WNSELGKSFTASVTDLKPQHTYRFRILAVYSNNDNKESNTSAKFYLQPGAALDPMPVP-----EL 584
                  :..|.:|:.|:|...|.|.:.||.:...::.|..|.....|..:...|:..|     .|
Human   610 ------QLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQDSSPSRPVEDPWRGQQGL 668

  Fly   585 LEIEEYSETAVVL-------HWSLASDADEHLITGYYAYYRPSS-SAGEYFKATIEGAHARSFKI 641
            .|:....:..:||       .|::  |....|:.|:...:|.:. ..|.:....::....:|..:
Human   669 AEVAVRLQEPIVLGPRTLQVSWTV--DGPVQLVQGFRVSWRVAGPEGGSWTMLDLQSPSQQSTVL 731

  Fly   642 APLETATMYEFKLQS 656
            ..|...|..:.|:|:
Human   732 RGLPPGTQIQIKVQA 746

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ihogNP_609085.1 Ig 266..348 CDD:472250 23/83 (28%)
Ig strand B 278..282 CDD:409353 0/3 (0%)
Ig strand C 291..295 CDD:409353 0/3 (0%)
Ig strand E 313..317 CDD:409353 2/3 (67%)
Ig strand F 327..332 CDD:409353 3/4 (75%)
Ig strand G 341..344 CDD:409353 0/2 (0%)
Ig 352..437 CDD:472250 24/93 (26%)
Ig strand B 369..373 CDD:409353 0/3 (0%)
Ig strand C 382..386 CDD:409353 1/3 (33%)
Ig strand E 404..407 CDD:409353 2/9 (22%)
Ig strand F 417..422 CDD:409353 2/4 (50%)
Ig strand G 430..433 CDD:409353 1/2 (50%)
FN3 467..565 CDD:238020 22/107 (21%)
FN3 582..>655 CDD:238020 15/85 (18%)
ROBO3NP_071765.2 Ig 64..162 CDD:472250 29/115 (25%)
Ig strand B 81..85 CDD:409353 1/3 (33%)
Ig strand C 94..98 CDD:409353 0/3 (0%)
Ig strand E 121..125 CDD:409353 0/3 (0%)
Ig strand F 140..145 CDD:409353 2/4 (50%)
Ig strand G 154..157 CDD:409353 1/2 (50%)
Ig 169..254 CDD:472250 26/91 (29%)
Ig strand B 183..187 CDD:409353 0/3 (0%)
Ig strand C 197..201 CDD:409353 2/3 (67%)
Ig strand E 219..223 CDD:409353 2/3 (67%)
Ig strand F 233..238 CDD:409353 2/4 (50%)
Ig strand G 247..250 CDD:409353 1/2 (50%)
Ig 261..343 CDD:472250 25/86 (29%)
Ig strand B 275..279 CDD:409353 0/3 (0%)
Ig strand C 288..292 CDD:409353 0/3 (0%)
Ig strand E 309..313 CDD:409353 2/3 (67%)
Ig strand F 323..328 CDD:409353 3/4 (75%)
Ig strand G 336..339 CDD:409353 0/2 (0%)
Ig 348..445 CDD:472250 23/96 (24%)
Ig strand B 364..368 CDD:409353 0/3 (0%)
Ig strand C 377..381 CDD:409353 1/3 (33%)
Ig strand E 407..411 CDD:409353 1/3 (33%)
Ig strand F 421..426 CDD:409353 2/4 (50%)
Ig strand G 434..437 CDD:409353 1/2 (50%)
Ig 452..536 CDD:472250 8/83 (10%)
Ig strand B 468..472 CDD:409353 0/3 (0%)
Ig strand C 481..485 CDD:409353 0/3 (0%)
Ig strand E 504..508 CDD:409353 0/3 (0%)
FN3 <518..>809 CDD:442628 41/243 (17%)
Ig strand F 518..523 CDD:409353 0/4 (0%)
Ig strand G 531..534 CDD:409353 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 541..563 4/21 (19%)
FN3 556..649 CDD:238020 19/104 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 639..662 4/22 (18%)
FN3 770..863 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 965..989
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1028..1310
PRK12323 <1126..1325 CDD:481241
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1327..1386
Blue background indicates that the domain is not in the aligned region.

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