DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ihog and ROBO2

DIOPT Version :10

Sequence 1:NP_609085.1 Gene:ihog / 33972 FlyBaseID:FBgn0031872 Length:886 Species:Drosophila melanogaster
Sequence 2:XP_011532283.1 Gene:ROBO2 / 6092 HGNCID:10250 Length:1597 Species:Homo sapiens


Alignment Length:1062 Identity:219/1062 - (20%)
Similarity:343/1062 - (32%) Gaps:346/1062 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 RILRAPESLVAPLGDEVVLECETSLQP-ERFEW---------------SHRSSRSPGAGFKYLKT 102
            ||:..|..::...|:...|.|:...:| ...||               |||.....|:.| :|:.
Human    55 RIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLF-FLRI 118

  Fly   103 GTAKANVSQEAAISRLRVLVRPDTLGEYRCV--GWFGPLVVTSTIARLELASTSLVDAQESESPL 165
            ...:.:              :||. |.|.||  .:.|..|  |..|.||:|   |:.....::|.
Human   119 VHGRRS--------------KPDE-GSYVCVARNYLGEAV--SRNASLEVA---LLRDDFRQNPT 163

  Fly   166 QWRVSAGNSVLWSCGQQVQSNPSAS--WSYYRNGVEIKPEFIG-TNGNLFLSNVSSESSGSYSCQ 227
            ...|:||...:..| |..:.:|..:  |...:..::.|.|.|. ..|.|.:||.....:|.|:|.
Human   164 DVVVAAGEPAILEC-QPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCV 227

  Fly   228 ATNPASGERIQLPGSLQLQVTPEQRSESKSPHLLRGQPSSQEITIREGSSLLLLCPGVGSPPPTV 292
            .||.. |||...|..|.:         .:.|..|| :|.:|  .:.|..::...|...|.|.|||
Human   228 GTNMV-GERDSDPAELTV---------FERPTFLR-RPINQ--VVLEEEAVEFRCQVQGDPQPTV 279

  Fly   293 VWSSPDVVGAVKNKRSKVFGHALEISNTRVNDAGTYICFQDNGV---RPALEHYIKVHVEQPPQI 354
            .|...| ....:.:......:.|.|..|...|.|||:|..:|.|   ..:....::.....|||.
Human   280 RWKKDD-ADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRARPVAPPQF 343

  Fly   355 VRPPWADLTNEGDRLKLECKATGVPTPEIYWLLNGHSSI--------DDSEAELS-NNFLILHSV 410
            |..|...:..:|..:...|:..|.|.|.::|...|..::        .:|...:| ...|.:.::
Human   344 VVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNI 408

  Fly   411 LKRHAGYVQCFARNRLGEHSAGTLLQVN--------PKQIQEPR------------ESGGTHRPK 455
            .:..|||..|.|....|...|...|:|.        |..:|.|.            :...|..|.
Human   409 QRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPL 473

  Fly   456 P---------------------NQGSRQ------------------------------------- 462
            |                     .||:.|                                     
Human   474 PVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGAT 538

  Fly   463 -KQMY-------PPTPPNVTRLSDESVMLRWMVPRNDGLPIVIFKVQYRMVGKRKNWQTTNDNIP 519
             .:.|       ||:.|.||.::..||.|.|.......||...:.::........:|||..::: 
Human   539 ISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHV- 602

  Fly   520 YGKPKWNSELGKSFTASVTDLKPQHTYRFRILAVYSNNDNKESNTSAKFYLQPGAALDPMPVPEL 584
                       |:...:|..|:|...|.|.:.|:                 .|....||.|:.:.
Human   603 -----------KTTLYTVRGLRPNTIYLFMVRAI-----------------NPQGLSDPSPMSDP 639

  Fly   585 LEIEEYSETA----------------VVLH-------------WSLASDADEHLITGYYAYYRPS 620
            :..::.|..|                |.||             |::  |.....|.||...||.:
Human   640 VRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTV--DRQPQFIQGYRVMYRQT 702

  Fly   621 S-----SAGEYFKATIEGAHARSFKIAPLETATMYEFKLQSFSAASASEFSALKQGRTQRPKT-S 679
            |     |:.:...|.:  ...||..:..|:....||.|::.:    .:||    ||.....|| .
Human   703 SGLQATSSWQNLDAKV--PTERSAVLVNLKKGVTYEIKVRPY----FNEF----QGMDSESKTVR 757

  Fly   680 TTEE---------PTLQMGDRDTTT---------PSHNETFNMSPMLTGTIGGGAVLILLLISTC 726
            ||||         ..|.:|..::|:         |.|.         .|.|....:         
Human   758 TTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQ---------NGIIQEYKI--------- 804

  Fly   727 FCVCRRRNSRSRGNNP----NKPRMAELRDDFVPLGNCSPTKQ------RQRTRHIHITLNP--- 778
            :|:         ||..    ||...|.:|.  |.:|...|..|      ...:..:.:...|   
Human   805 WCL---------GNETRFHINKTVDAAIRS--VIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPI 858

  Fly   779 -LAQQQQQALEEKND--TDQDAPYYQRP-----------------SSYDYDPTLRRMSSSSLRRS 823
             :.::.:..:.|.|:  |:|.....::|                 |.:.|   .||.....|...
Human   859 IIGRRNEVVITENNNSITEQITDVVKQPAFIAGIGGACWVILMGFSIWLY---WRRKKRKGLSNY 920

  Fly   824 QRTLERAGG---SNGSNNG-----------------------NNNNLNQSAEAGSIENPGKPGRV 862
            ..|.:|..|   ||||..|                       ||:|    :....|.|.|: |.|
Human   921 AVTFQRGDGGLMSNGSRPGLLNAGDPSYPWLADSWPATSLPVNNSN----SGPNEIGNFGR-GDV 980

  Fly   863 LMKRPRLSSRSEN-LSSGSLNS 883
            |...|....::.. ||.|::.|
Human   981 LPPVPGQGDKTATMLSDGAIYS 1002

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ihogNP_609085.1 Ig 266..348 CDD:472250 20/84 (24%)
Ig strand B 278..282 CDD:409353 0/3 (0%)
Ig strand C 291..295 CDD:409353 2/3 (67%)
Ig strand E 313..317 CDD:409353 1/3 (33%)
Ig strand F 327..332 CDD:409353 3/4 (75%)
Ig strand G 341..344 CDD:409353 0/2 (0%)
Ig 352..437 CDD:472250 22/93 (24%)
Ig strand B 369..373 CDD:409353 0/3 (0%)
Ig strand C 382..386 CDD:409353 0/3 (0%)
Ig strand E 404..407 CDD:409353 1/2 (50%)
Ig strand F 417..422 CDD:409353 2/4 (50%)
Ig strand G 430..433 CDD:409353 1/2 (50%)
FN3 467..565 CDD:238020 21/97 (22%)
FN3 582..>655 CDD:238020 21/106 (20%)
ROBO2XP_011532283.1 IgC_1_Robo 54..152 CDD:409490 27/114 (24%)
Ig strand A 54..58 CDD:409490 2/2 (100%)
Ig strand A' 61..66 CDD:409490 0/4 (0%)
Ig strand B 70..78 CDD:409490 2/7 (29%)
Ig strand C 84..89 CDD:409490 2/4 (50%)
Ig strand C' 92..94 CDD:409490 0/1 (0%)
Ig strand D 105..108 CDD:409490 1/2 (50%)
Ig strand E 111..117 CDD:409490 2/6 (33%)
Ig strand F 129..137 CDD:409490 4/7 (57%)
Ig strand G 140..152 CDD:409490 6/13 (46%)
Ig 159..244 CDD:472250 25/86 (29%)
Ig strand B 173..177 CDD:409353 0/3 (0%)
Ig strand C 187..191 CDD:409353 0/3 (0%)
Ig strand E 209..213 CDD:409353 2/3 (67%)
Ig strand F 223..228 CDD:409353 2/4 (50%)
Ig strand G 237..240 CDD:409353 0/2 (0%)
Ig 251..333 CDD:472250 23/85 (27%)
Ig strand B 265..269 CDD:409353 0/3 (0%)
Ig strand C 278..282 CDD:409353 2/3 (67%)
Ig strand E 299..303 CDD:409353 1/3 (33%)
Ig strand F 313..318 CDD:409353 3/4 (75%)
Ig strand G 326..329 CDD:409353 0/2 (0%)
IgI_4_Robo 342..439 CDD:409391 22/96 (23%)
Ig strand A 342..346 CDD:409391 2/3 (67%)
Ig strand A' 348..352 CDD:409391 0/3 (0%)
Ig strand B 358..366 CDD:409391 1/7 (14%)
Ig strand C 369..376 CDD:409391 2/6 (33%)
Ig strand C' 378..381 CDD:409391 1/2 (50%)
Ig strand D 394..399 CDD:409391 0/4 (0%)
Ig strand E 401..408 CDD:409391 1/6 (17%)
Ig strand F 414..423 CDD:409391 4/8 (50%)
Ig strand G 425..436 CDD:409391 3/10 (30%)
IgI_5_Robo 446..532 CDD:409544 8/85 (9%)
Ig strand A 446..449 CDD:409544 0/2 (0%)
Ig strand A' 453..456 CDD:409544 0/2 (0%)
Ig strand B 462..469 CDD:409544 0/6 (0%)
Ig strand C 475..480 CDD:409544 0/4 (0%)
Ig strand C' 482..484 CDD:409544 0/1 (0%)
Ig strand D 491..495 CDD:409544 0/3 (0%)
Ig strand E 498..503 CDD:409544 2/4 (50%)
FN3 <510..882 CDD:442628 80/441 (18%)
Ig strand F 511..519 CDD:409544 0/7 (0%)
Ig strand G 522..532 CDD:409544 0/9 (0%)
FN3 549..642 CDD:238020 25/121 (21%)

Return to query results.
Submit another query.