Protein Alignment ihog and ROBO2

DIOPT Version :9

• Sequence 1: NP_609085.1
• Gene: ihog / 33972
• FlyBaseID: FBgn0031872
• Length: 886
• Species: Drosophila melanogaster
• Sequence 2: XP_011532283.1
• Gene: ROBO2 / 6092
• HGNCID: 10250
• Length: 1597
• Species: Homo sapiens
• Alignment Length: 1062
• Identity: 219/1062 - (20%)
• Similarity: 343/1062 - (32%)
• Gaps: 346/1062 - (32%)

  Fly    54 RILRAPESLVAPLGDEVVLECETSLQP-ERFEW---------------SHRSSRSPGAGFKYLKT 102
            ||:..|..::...|:...|.|:...:| ...||               |||.....|:.| :|:.
Human    55 RIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLF-FLRI 118

  Fly   103 GTAKANVSQEAAISRLRVLVRPDTLGEYRCV--GWFGPLVVTSTIARLELASTSLVDAQESESPL 165
            ...:.:              :||. |.|.||  .:.|..|  |..|.||:|   |:.....::|.
Human   119 VHGRRS--------------KPDE-GSYVCVARNYLGEAV--SRNASLEVA---LLRDDFRQNPT 163

  Fly   166 QWRVSAGNSVLWSCGQQVQSNPSAS--WSYYRNGVEIKPEFIG-TNGNLFLSNVSSESSGSYSCQ 227
            ...|:||...:..| |..:.:|..:  |...:..::.|.|.|. ..|.|.:||.....:|.|:|.
Human   164 DVVVAAGEPAILEC-QPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCV 227

  Fly   228 ATNPASGERIQLPGSLQLQVTPEQRSESKSPHLLRGQPSSQEITIREGSSLLLLCPGVGSPPPTV 292
            .||.. |||...|..|.:         .:.|..|| :|.:|  .:.|..::...|...|.|.|||
Human   228 GTNMV-GERDSDPAELTV---------FERPTFLR-RPINQ--VVLEEEAVEFRCQVQGDPQPTV 279

  Fly   293 VWSSPDVVGAVKNKRSKVFGHALEISNTRVNDAGTYICFQDNGV---RPALEHYIKVHVEQPPQI 354
            .|...| ....:.:......:.|.|..|...|.|||:|..:|.|   ..:....::.....|||.
Human   280 RWKKDD-ADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRARPVAPPQF 343

  Fly   355 VRPPWADLTNEGDRLKLECKATGVPTPEIYWLLNGHSSI--------DDSEAELS-NNFLILHSV 410
            |..|...:..:|..:...|:..|.|.|.::|...|..::        .:|...:| ...|.:.::
Human   344 VVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNI 408

  Fly   411 LKRHAGYVQCFARNRLGEHSAGTLLQVN--------PKQIQEPR------------ESGGTHRPK 455
            .:..|||..|.|....|...|...|:|.        |..:|.|.            :...|..|.
Human   409 QRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPL 473

  Fly   456 P---------------------NQGSRQ------------------------------------- 462
            |                     .||:.|
Human   474 PVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGAT 538

  Fly   463 -KQMY-------PPTPPNVTRLSDESVMLRWMVPRNDGLPIVIFKVQYRMVGKRKNWQTTNDNIP 519
             .:.|       ||:.|.||.::..||.|.|.......||...:.::........:|||..:::
Human   539 ISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHV- 602

  Fly   520 YGKPKWNSELGKSFTASVTDLKPQHTYRFRILAVYSNNDNKESNTSAKFYLQPGAALDPMPVPEL 584
                       |:...:|..|:|...|.|.:.|:                 .|....||.|:.:.
Human   603 -----------KTTLYTVRGLRPNTIYLFMVRAI-----------------NPQGLSDPSPMSDP 639

  Fly   585 LEIEEYSETA----------------VVLH-------------WSLASDADEHLITGYYAYYRPS 620
            :..::.|..|                |.||             |::  |.....|.||...||.:
Human   640 VRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTV--DRQPQFIQGYRVMYRQT 702

  Fly   621 S-----SAGEYFKATIEGAHARSFKIAPLETATMYEFKLQSFSAASASEFSALKQGRTQRPKT-S 679
            |     |:.:...|.:  ...||..:..|:....||.|::.:    .:||    ||.....|| .
Human   703 SGLQATSSWQNLDAKV--PTERSAVLVNLKKGVTYEIKVRPY----FNEF----QGMDSESKTVR 757

  Fly   680 TTEE---------PTLQMGDRDTTT---------PSHNETFNMSPMLTGTIGGGAVLILLLISTC 726
            ||||         ..|.:|..::|:         |.|.         .|.|....:
Human   758 TTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQ---------NGIIQEYKI--------- 804

  Fly   727 FCVCRRRNSRSRGNNP----NKPRMAELRDDFVPLGNCSPTKQ------RQRTRHIHITLNP--- 778
            :|:         ||..    ||...|.:|.  |.:|...|..|      ...:..:.:...|
Human   805 WCL---------GNETRFHINKTVDAAIRS--VIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPI 858

  Fly   779 -LAQQQQQALEEKND--TDQDAPYYQRP-----------------SSYDYDPTLRRMSSSSLRRS 823
             :.::.:..:.|.|:  |:|.....::|                 |.:.|   .||.....|...
Human   859 IIGRRNEVVITENNNSITEQITDVVKQPAFIAGIGGACWVILMGFSIWLY---WRRKKRKGLSNY 920

  Fly   824 QRTLERAGG---SNGSNNG-----------------------NNNNLNQSAEAGSIENPGKPGRV 862
            ..|.:|..|   ||||..|                       ||:|    :....|.|.|: |.|
Human   921 AVTFQRGDGGLMSNGSRPGLLNAGDPSYPWLADSWPATSLPVNNSN----SGPNEIGNFGR-GDV 980

  Fly   863 LMKRPRLSSRSEN-LSSGSLNS 883
            |...|....::.. ||.|::.|
Human   981 LPPVPGQGDKTATMLSDGAIYS 1002

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ihog	NP_609085.1	IG_like	59..145	CDD:214653	22/103 (21%)
		ig	265..330	CDD:278476	18/64 (28%)
		IG_like	267..348	CDD:214653	20/83 (24%)
		Ig	314..>377	CDD:299845	17/65 (26%)
		IG_like	364..437	CDD:214653	18/81 (22%)
		IGc2	365..427	CDD:197706	15/70 (21%)
		FN3	467..565	CDD:238020	21/97 (22%)
		fn3	580..655	CDD:278470	22/108 (20%)
ROBO2	XP_011532283.1	Ig1_Robo	53..152	CDD:143317	27/114 (24%)
		Ig	160..244	CDD:325142	25/85 (29%)
		Ig	265..333	CDD:325142	18/68 (26%)
		Ig4_Robo	355..444	CDD:143203	19/88 (22%)
		IG	451..532	CDD:214652	7/80 (9%)
		FN3	549..642	CDD:238020	25/121 (21%)
		FN3	673..758	CDD:238020	22/96 (23%)
		FN3	766..859	CDD:238020	19/121 (16%)
		PTN13_u3	<1374..>1431	CDD:318742

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44170
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010