DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ihog and Cdon

DIOPT Version :9

Sequence 1:NP_609085.1 Gene:ihog / 33972 FlyBaseID:FBgn0031872 Length:886 Species:Drosophila melanogaster
Sequence 2:NP_067314.2 Gene:Cdon / 57810 MGIID:1926387 Length:1250 Species:Mus musculus


Alignment Length:1018 Identity:204/1018 - (20%)
Similarity:335/1018 - (32%) Gaps:386/1018 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 PESLVAPLGDEVVLECETSLQPERFEWSHRSSRSPGAGFKYLKTGTAKANVSQEAAISRLRVL-V 122
            |.|.|..||..|||.|.......|..|.|...|        |...|.:..:.:    ..|.:| :
Mouse    34 PLSAVQKLGRPVVLHCSAKPVTARISWLHNGKR--------LDRNTEQIKIHR----GTLTILSL 86

  Fly   123 RPDTLGEYRCVG-------WFGPLVVT-STIARLELASTSLVDAQESESPLQWRVSAGNSVLWSC 179
            .|...|.|:||.       ..||..|: :.:...:.::..::.|:|.           |:....|
Mouse    87 NPSLSGCYQCVANNSVGAVVSGPATVSAAALGDFDSSTMHVITAEEK-----------NTGFIGC 140

  Fly   180 GQQVQSNPSASWSYYRNGVEIKPE----FIGTNGNLFLSNVSSESSGSYSCQATNPASGERIQLP 240
             :..:|||.|...|...|..:|..    .|..:|||.:.||||:..|||.|.|.||.:.|....|
Mouse   141 -RVPESNPKAEVRYKIRGKWLKHSTGNYIILPSGNLQVLNVSSKDKGSYKCAAYNPVTSELKVEP 204

  Fly   241 GSLQLQVTPEQRSESKSPHLLR----------------------GQPSSQEITIRE--------- 274
            ...:|.|:   |..|...|:|.                      |.|:||...:::         
Mouse   205 TGRKLLVS---RPSSNGFHILHPALSQALAVLPHSPVTLECVVSGVPASQVYWLKDGQDAVAGSN 266

  Fly   275 ----------------------------------------------------------GSSLLLL 281
                                                                      |:::...
Mouse   267 WRRLYSHLATASIDPADSGNYSCVVGNKSGDVKHVTYMVNVLEHASISKGLHDQKVSLGATVHFT 331

  Fly   282 CPGVGSPPPTVVW---SSPDVVGAVKNKRSKVFGHALEISNTRVNDAGTYICFQDNGVRPALEHY 343
            |...|:|.|...|   :.|    ...:.|....|:.|:|:...:.|:|.|.|..|||: ..::..
Mouse   332 CDVHGNPAPNRTWFHNAQP----IHPSSRHLTEGNVLKITRVVMEDSGLYQCVADNGI-GFMQST 391

  Fly   344 IKVHVEQ----PPQIVRPPWADLTNEGDRLKLECKATGVPTPEIYW-----LLNGH-SSIDDSEA 398
            .::.:||    .|.||..|......:||.:.|.|.|||||.|.|:|     |:..| |.:..|:.
Mouse   392 GRLQIEQDSGWKPVIVTAPANIEVMDGDFVTLSCNATGVPVPVIHWYGRHGLITSHPSQVLRSKP 456

  Fly   399 ELSNNF---------------------LILHSVLKRHAGYVQCFARNRLG--------------- 427
            ..|:.|                     |.:.:|...|||...|.|.|:.|               
Mouse   457 RKSHLFRPGDLDLEPVYLIMSQAGSSSLSIQAVTLEHAGKYTCEATNKHGSTQSEAFLTVVPFET 521

  Fly   428 ---------------------EHSAGTLL-----QVNPKQIQEPRESGG-------------THR 453
                                 :.|..:||     :|:|..::.|.|...             ||.
Mouse   522 NTKAESVTPSEASQNDERDPQDGSESSLLNLFPVKVHPSGVELPAERNASVPDAPNILSPPQTHM 586

  Fly   454 P-------------------------KPNQG---------------------------------- 459
            |                         |.:.|                                  
Mouse   587 PDTYNLVWRAGRDGGMPINAYFVKYRKLDDGSGAVGSWHTVRVPGSENELHLTELEPSSLYEVLM 651

  Fly   460 ------------------SRQKQ--------MYPPT----------------------------- 469
                              |::|.        .:||.                             
Mouse   652 VARSAVGEGQPAMLTFRTSKEKMASSKNTQASFPPVGVPKRPVTAEASNSNFGVVLTDSSRHSGV 716

  Fly   470 -----PPNVTRLSDESVMLRWMVPRNDGLPIVIFKVQYRMVGKRKNWQTTNDNIPYGKPKWNSEL 529
                 .|.::..|:.||.:.|:...|.|.||..|||:|:.: :..:|....::||..|       
Mouse   717 PEAPDRPTISMASETSVYVTWIPRANGGSPITAFKVEYKRM-RTSDWLVAAEDIPPSK------- 773

  Fly   530 GKSFTASVTDLKPQHTYRFRILAVYSNNDNKESNTSAKFYLQ--PGAALD-PMPVPELLEIEEYS 591
               .:..|..|:|...|:||::|:....::..|:.|..:.:.  |....: |:..|.:...|..|
Mouse   774 ---LSVEVRSLEPGSIYKFRVIAINHYGESFRSSASRPYQVAGFPNRFSNRPITGPHIAYTEAVS 835

  Fly   592 ETAVVLHWSLASDADEHL-ITGYYAYYRP--SSSAGEYFKATIEGA---HARSFKIAPLETATMY 650
            :|.::|.|:....::.:. |.|:|.||||  |.:..:|.:..:||:   |.    |..|:..|.|
Mouse   836 DTQIMLKWTYVPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHT----IGHLQPETSY 896

  Fly   651 EFKLQSFSAASASEFSALKQGRTQRPKT-STTEEPTLQMGDRDTTTP--SHNETFNMSP------ 706
            :.|:|.|:....||||.:....|:..:. ..::.|.     ::.:||  |.....|:.|      
Mouse   897 DIKMQCFNEGGESEFSNVMICETKVKRVPGASDYPV-----KELSTPPSSSGNAGNVGPATSPAR 956

  Fly   707 ------MLTGTIGGGAVLILLL-ISTCFCVCRRRNSRSRGNNP 742
                  ::.|.:.|..||||:: |:.|....|::::..:.:.|
Mouse   957 SSDMLYLIVGCVLGVMVLILMVFIALCLWKSRQQSTIQKYDPP 999

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ihogNP_609085.1 IG_like 59..145 CDD:214653 25/94 (27%)
ig 265..330 CDD:278476 17/134 (13%)
IG_like 267..348 CDD:214653 20/150 (13%)
Ig 314..>377 CDD:299845 20/66 (30%)
IG_like 364..437 CDD:214653 30/140 (21%)
IGc2 365..427 CDD:197706 26/88 (30%)
FN3 467..565 CDD:238020 27/131 (21%)
fn3 580..655 CDD:278470 23/80 (29%)
CdonNP_067314.2 Ig 28..113 CDD:416386 24/90 (27%)
Ig strand A 28..31 CDD:409353
Ig strand B 45..52 CDD:409353 4/6 (67%)
Ig strand C 57..62 CDD:409353 2/4 (50%)
Ig strand C' 65..67 CDD:409353 1/9 (11%)
Ig strand D 73..77 CDD:409353 0/3 (0%)
Ig strand E 79..83 CDD:409353 1/3 (33%)
Ig strand F 92..100 CDD:409353 4/7 (57%)
Ig strand G 103..113 CDD:409353 2/9 (22%)
Ig 120..196 CDD:416386 25/87 (29%)
Ig strand A 120..123 CDD:409353 0/2 (0%)
Ig strand B 133..144 CDD:409353 2/22 (9%)
Ig strand C 149..155 CDD:409353 2/5 (40%)
Ig strand C' 157..160 CDD:409353 1/2 (50%)
Ig strand D 167..171 CDD:409353 1/3 (33%)
Ig strand E 173..179 CDD:409353 3/5 (60%)
Ig strand F 185..194 CDD:409353 5/8 (63%)
IGc2 236..296 CDD:197706 4/59 (7%)
Ig strand B 237..245 CDD:409353 0/7 (0%)
Ig strand C 251..256 CDD:409353 1/4 (25%)
Ig strand D 265..268 CDD:409353 0/2 (0%)
Ig strand E 272..277 CDD:409353 0/4 (0%)
Ig strand F 286..293 CDD:409353 0/6 (0%)
Ig strand G 296..307 CDD:409353 0/10 (0%)
Ig 319..396 CDD:416386 18/81 (22%)
Ig strand A' 319..323 CDD:409353 0/3 (0%)
Ig strand B 326..336 CDD:409353 1/9 (11%)
Ig strand C 341..347 CDD:409353 1/5 (20%)
Ig strand C' 348..351 CDD:409353 1/6 (17%)
Ig strand E 362..368 CDD:409353 2/5 (40%)
Ig strand F 375..383 CDD:409353 3/7 (43%)
Ig strand G 386..396 CDD:409353 0/9 (0%)
I-set 404..516 CDD:400151 31/111 (28%)
Ig strand B 421..425 CDD:409353 1/3 (33%)
Ig strand C 434..438 CDD:409353 1/3 (33%)
Ig strand E 482..486 CDD:409353 1/3 (33%)
Ig strand F 496..501 CDD:409353 1/4 (25%)
Ig strand G 510..513 CDD:409353 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 524..547 1/22 (5%)
fn3 <594..662 CDD:394996 2/67 (3%)
FN3 717..807 CDD:238020 25/100 (25%)
FN3 832..919 CDD:238020 28/90 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 929..951 5/26 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1178..1208
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1223..1250
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 57 1.000 Domainoid score I10818
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 209 1.000 Inparanoid score I3668
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
43.920

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