DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ihog and IGDCC4

DIOPT Version :9

Sequence 1:	NP_609085.1	Gene:	ihog / 33972	FlyBaseID:	FBgn0031872	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	XP_016877937.1	Gene:	IGDCC4 / 57722	HGNCID:	13770	Length:	1264	Species:	Homo sapiens

Alignment Length:	690	Identity:	163/690 - (23%)
Similarity:	245/690 - (35%)	Gaps:	163/690 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 LGDE--VVLECETSL----QPERFEWS--------HRSSRSPGAGFKYLKTGTAKANVSQEAAIS 116
            ||.|  .||.|....    .|.|..||        |........|..:|....| .|.|.|:...
Human    60 LGPEQAAVLNCSLGAAAAGPPTRVTWSKDGDTLLEHDHLHLLPNGSLWLSQPLA-PNGSDESVPE 123

  Fly   117 RLRVLVRPDTLGEYRCVGWFGPL-VVTSTIARLELASTSLVDAQESESPLQWRVSAGNSVLWSCG 180
            .:.|:.     |.|.|:. .||| |:.|..|.::||:.    |..|..|....|....:..:.|.
Human   124 AVGVIE-----GNYSCLA-HGPLGVLASQTAVVKLATL----ADFSLHPESQTVEENGTARFECH 178

  Fly   181 QQVQSNPSASWSYYRNGVEIKPEFIG-TNGNLFLSNVSSESSGSYSCQATNPASGERIQLPGSLQ 244
            .:....|..:|...:..:..:|..|. .||.|.:.:|....:|.|.|.|||.|.....|     :
Human   179 IEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQ-----E 238

  Fly   245 LQVTPEQRSESKSPHLLRGQ-----PSSQEITIREGSSLLLLCPGVGSPPPTVVW-------SSP 297
            ..::...|....|   .|||     .:.:..|:..|.|:::.|.....|.|.|.|       .|.
Human   239 ALLSVAHRGSLAS---TRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPIST 300

  Fly   298 DVVGAVKNKRSKVFGHA-LEISNTRVNDAGTYICFQDNGVRPALEHY----IKVHVEQPPQIVRP 357
            ||:         |.|.. |.|:|.:...:|.|:|   ...:|....:    .::.|...|.|.:.
Human   301 DVI---------VLGRTNLLIANAQPWHSGVYVC---RANKPRTRDFATAAAELRVLAAPAITQA 353

  Fly   358 PWADLTNEGDRLKLECKATGVPTPEIYWLLNGHSSIDDSEAEL--SNNFLILHSVLKRHAGYVQC 420
            |.|.........:..|:|:|.|.|.:.||.||.....:...::  ....|::..:..:.|||.||
Human   354 PEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQC 418

  Fly   421 FARNRLGEHSAGTLLQVNPKQIQEPRESGGTHRPKPNQGSRQKQMYPPTPPNVTRLSDESVMLRW 485
            .|.|..|...|...|.|   .::|...|.                  ||....|.||..:|::.|
Human   419 VAENSAGMACAAASLAV---VVREGLPSA------------------PTRVTATPLSSSAVLVAW 462

  Fly   486 MVPRNDGLPIVIFKVQYRMVGKRKNWQTTNDNIPYGKPKWN--SELGKSFTASVTDLKPQHTYRF 548
            ..|......|:.|.:.|:   |.:..    ||:.|.....|  :||      .|.||:|...|.|
Human   463 ERPEMHSEQIIGFSLHYQ---KARGM----DNVEYQFAVNNDTTEL------QVRDLEPNTDYEF 514

  Fly   549 RILAVYSNNDNKESNTSAKFYLQPGAALDPMP--VPELLEIEEYSETAVVLHWSLASDADEHLIT 611
            .::| ||......::|.|..:     .||.:|  .|:|               ||:|.....:..
Human   515 YVVA-YSQLGASRTSTPALVH-----TLDDVPSAAPQL---------------SLSSPNPSDIRV 558

  Fly   612 GYYAYYRPSSSAGEYFKATIE---GAHARSFK-----------IAPLETATMYEFKLQSFSAASA 662
            .:.. ..||.|.|:..|..||   |...:.|.           :..|:...:|..::   ||.:|
Human   559 AWLP-LPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRI---SAGTA 619

  Fly   663 SEFSALKQGRTQRPKTSTTEEPTLQMGDRDTTTPS-HNET 701
            :.|.|..|....|                   ||| ||::
Human   620 AGFGAPSQWMHHR-------------------TPSMHNQS 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ihog	NP_609085.1	IG_like	59..145	CDD:214653	26/93 (28%)
		ig	265..330	CDD:278476	18/72 (25%)
		IG_like	267..348	CDD:214653	20/92 (22%)
		Ig	314..>377	CDD:299845	14/67 (21%)
		IG_like	364..437	CDD:214653	20/74 (27%)
		IGc2	365..427	CDD:197706	17/63 (27%)
		FN3	467..565	CDD:238020	27/99 (27%)
		fn3	580..655	CDD:278470	17/90 (19%)
IGDCC4	XP_016877937.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44170
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100