DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ihog and Igdcc4

DIOPT Version :9

Sequence 1:	NP_609085.1	Gene:	ihog / 33972	FlyBaseID:	FBgn0031872	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	XP_006511369.1	Gene:	Igdcc4 / 56741	MGIID:	1858497	Length:	1312	Species:	Mus musculus

Alignment Length:	747	Identity:	170/747 - (22%)
Similarity:	270/747 - (36%)	Gaps:	167/747 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLFSLLTSRLEAIPVLEKSPAHPAHSAHPAHPA--------------------HPAHPAHPSPG 52
            :|.|.||::|.:......:..|.||    ||..|                    |.|.|....|.
Mouse    12 VLTFCLLSARGKGPGGRSREWASPA----PAMLARRGLWGLAPRGCVSLLCTAWHRACPPARGPC 72

  Fly    53 VRILRAPES-----------LVAPLGDE--VVLECETSL----QPERFEWS--------HRSSRS 92
            ...|..|:.           |...||.|  |||:|....    .|.|..||        |.:...
Mouse    73 AWELPLPQETTVKLSCDEGPLQVILGPEQAVVLDCTLGATAAGPPTRVTWSKDGDTVLEHENLHL 137

  Fly    93 PGAGFKYLKTGTAKANVSQEAAISRLRVLVRPDTLGEYRCVGWFGPL-VVTSTIARLELASTSLV 156
            ...|..:|.:...:.:...|.|:...:|     |.|.|.|:. ..|| ||.|.:|.::||  :|.
Mouse   138 LPNGSLWLSSPLEQEDSDDEEALRIWKV-----TEGSYSCLA-HSPLGVVASQVAVVKLA--TLE 194

  Fly   157 D-AQESESPLQWRVSAGNSVLWSCGQQVQSNPSASWSYYRNGVEIKPE---FIGTNGNLFLSNVS 217
            | :...||.:   |....:..:.|..:....|..:|.  ::.|.:..|   ....||.|.:.:|.
Mouse   195 DFSLHPESQI---VEENGTARFECHTKGLPAPIITWE--KDQVTVPEESRLITLPNGVLQILDVQ 254

  Fly   218 SESSGSYSCQATNPA-------SGERIQLPGSLQLQVTPEQRSESKSPHLLRGQ-----PSSQEI 270
            ...:|||.|.|||.|       :...:.|.|||:               ..|||     .:.:..
Mouse   255 DSDAGSYRCVATNSARQRFSQEASLTVALRGSLE---------------ATRGQDVVIVAAPENT 304

  Fly   271 TIREGSSLLLLCPGVGSPPPTVVW-------SSPDVVGAVKNKRSKVFGHA-LEISNTRVNDAGT 327
            |:..|.|:::.|.....|.|.|.|       .|.||:         |.|.. |.|::.:...:|.
Mouse   305 TVVSGQSVVMECVASADPTPFVSWVRQDGKPISTDVI---------VLGRTNLLIASAQPRHSGV 360

  Fly   328 YICFQDNGVRPALEHY----IKVHVEQPPQIVRPPWADLTNEGDRLKLECKATGVPTPEIYWLLN 388
            |:|   ...:|....:    .::.|...|.|.:.|.|.........:..|:|:|.|.|.::||.:
Mouse   361 YVC---RANKPRTRDFATAAAELRVLAAPAISQAPEALSRTRASTARFVCRASGEPRPALHWLHD 422

  Fly   389 GHSSIDDSEAEL--SNNFLILHSVLKRHAGYVQCFARNRLGEHSAGTLLQVNPKQIQEPRESGGT 451
            |.....:...::  ....|::..:..:.|||.||.|     |:||||.....|..:.
Mouse   423 GIPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVA-----ENSAGTACAAAPLAVV-------- 474

  Fly   452 HRPKPNQGSRQKQMYPPTPPNVTRLSDESVMLRWMVPRNDGLPIVIFKVQYRMVGKRKNWQTTND 516
                    .|:.....||....|.||..||::.|..|......|:.|.:.|:   |.:.    .|
Mouse   475 --------VREGLPSAPTRVTATPLSSSSVLVAWERPELHSEQIIGFSLHYQ---KARG----VD 524

  Fly   517 NIPYGKPKWN--SELGKSFTASVTDLKPQHTYRFRILAVYSNNDNKESNTSAKFYLQPGAALDPM 579
            |:.|.....|  :||      .|.||:|...|.|.::| ||......:::.|..:     .||.:
Mouse   525 NVEYQFAVNNDTTEL------QVRDLEPNTDYEFYVVA-YSQLGASRTSSPALVH-----TLDDV 577

  Fly   580 P--VPELLEIEEYSETAVVLHW-SLASDADEHLITGYYAYYRPSSSAGEYFKATIEGAHARSFKI 641
            |  .|: |.:...:.:.:.:.| .|.|......:..|...|.......:.|...:.| :.....:
Mouse   578 PSAAPQ-LTLSSPNPSDIRVAWLPLPSSLSNGQVLKYKIEYGLGKEEDQVFSTEVPG-NETQLTL 640

  Fly   642 APLETATMYEFKLQSFSAASASEFSALKQGRT 673
            ..|:...:|..::.:.:.|.....|...|.||
Mouse   641 NSLQPNKVYRVRISAGTGAGYGVPSQWMQHRT 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ihog	NP_609085.1	IG_like	59..145	CDD:214653	28/111 (25%)
		ig	265..330	CDD:278476	17/72 (24%)
		IG_like	267..348	CDD:214653	19/92 (21%)
		Ig	314..>377	CDD:299845	13/67 (19%)
		IG_like	364..437	CDD:214653	20/74 (27%)
		IGc2	365..427	CDD:197706	15/63 (24%)
		FN3	467..565	CDD:238020	28/99 (28%)
		fn3	580..655	CDD:278470	12/77 (16%)
Igdcc4	XP_006511369.1	Ig	89..190	CDD:386229	28/106 (26%)
		I-set	196..281	CDD:369462	20/89 (22%)
		IG	301..382	CDD:214652	19/92 (21%)
		Ig	401..473	CDD:386229	21/76 (28%)
		fn3	481..564	CDD:365830	28/96 (29%)
		FN3	578..672	CDD:238020	15/95 (16%)
		fn3	684..778	CDD:365830
		FN3	802..901	CDD:238020
		FN3	909..1001	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44170
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100