DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ihog and prtga

DIOPT Version :9

Sequence 1:	NP_609085.1	Gene:	ihog / 33972	FlyBaseID:	FBgn0031872	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_001038495.1	Gene:	prtga / 563834	ZFINID:	ZDB-GENE-061204-4	Length:	1149	Species:	Danio rerio

Alignment Length:	667	Identity:	161/667 - (24%)
Similarity:	264/667 - (39%)	Gaps:	103/667 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LRAPESLVAPLGDEVVLECETSLQPERFEWSHRSSRSPGAGFKYLKTGTAKANVSQEAAISRLRV 120
            ::.|..:.|...|.|||:|:          :|  ..:| .|.::||.|.......:..::|...:
Zfish    30 IKEPHDVTAMRRDAVVLDCQ----------AH--GEAP-IGIRWLKNGVTITESERVYSLSNGSL 81

  Fly   121 LV-----RPDTLGE--YRCVGW--FGPLVVTSTIARLELASTSLVDAQESESPLQWRVSAGNSVL 176
            |:     |.|...|  |:|:..  :|.::  |..|||.:||.|..    ::.|....|..|:...
Zfish    82 LISEVESRKDKSDEGFYQCLAQNKYGSIL--SQRARLTIASLSTF----TQQPASIIVMEGSVAR 140

  Fly   177 WSCGQQVQSNPSASWSYYRNGVEIKPEFIGT--NGNLFLSNVSSESSGSYSCQATNPASGERIQL 239
            ::|.......|..:|.:.|..:.:..|.|..  :|.|.:..|....:|||.|.|.|..|..|
Zfish   141 FTCKITATPPPIITWEFNRVTLPLATERITVLPSGVLQIQGVEQRDAGSYRCVAANIVSRRR--- 202

  Fly   240 PGSLQLQVTPEQRSES-KSPHLLRGQPSSQEITIREGSSLLLLCPGVGSPPPTVVWSSPDVVGAV 303
            .....|.|||.....: :.|.::.|   .|.:|:...|:.||.|...|:|.|.:.||..| ..::
Zfish   203 STEATLTVTPAMSPRAPQRPRIIAG---PQNLTVPAHSTALLECMASGNPRPLISWSRAD-HKSI 263

  Fly   304 KNKRSKVFGHA-LEISNTRVNDAGTYICFQDNGVRPALEHY----IKVHVEQPPQIVRPPWADLT 363
            ...::||.|:. |.||:.....||.|.|   ....|...:|    ..:.|..||.:|..|.:...
Zfish   264 DVHKTKVLGNGNLIISDVNPQHAGIYFC---RATTPGTRNYTIAAANITVLAPPSLVEWPESVTR 325

  Fly   364 NEGDRLKLECKATGVPTPEIYWLLNGHSSIDDSEAELSNNFLILHSVLKRHAGYVQCFARNRLGE 428
            ......:..|.|.|.|||:|.||.||.....:...::.|:.|:::.::....|..||.|.|..|.
Zfish   326 PRAGTARFVCTAEGFPTPQITWLKNGEPVRSNGRIKMYNSKLVINQIIPEDDGIYQCEAENIQGS 390

  Fly   429 HSAGTLLQVNPKQIQEPRESGGTHRPKPNQGSRQKQMYPPTPPNV--TRLSDESVMLRWMVPRND 491
            ..|...|.|   .:.:.|                    |..|.|:  ..:|..:::|.|..|..:
Zfish   391 VLAMARLIV---VMSDNR--------------------PSAPRNIRADTVSSSAIVLAWDRPAYN 432

  Fly   492 GLPIVIFKVQYRMVGKRKN--WQTT--NDNIPYGKPKWNSELGKSFTASVTDLKPQHTYRFRILA 552
            ...::.:.|.|.......|  :|..  ||...|               .:.||:....|.|.|:|
Zfish   433 SEKVIAYSVHYMKAEGLNNEEYQIVIGNDTTRY---------------IIDDLEAGRNYTFYIVA 482

  Fly   553 VYSNNDNKESNTSAKFYLQPGAALDPMPVPELLEIEEYSETAVVLHWS-LASDADEHLITGYYAY 616
            ......::.|:...:..|:.    .|:..|| |.:...|.:.:.:.|. |:.......::.|...
Zfish   483 YMPMGASRMSDHVIQHTLED----VPLRAPE-LSLTSRSPSDIQVSWQPLSHKLSRGRVSAYRLS 542

  Fly   617 YRPSSSAGEYFKATIEGAHARSFKIAPLETATMYEFKLQSFSAASASEFSALKQGRTQRPKTSTT 681
            || :||.|...:..: .||.....:..|:..|.|..::.:.:|....|.||....||  ||.|:|
Zfish   543 YR-TSSDGTLTQLEL-SAHKTHQLLEGLQPDTTYLLRIAAATAVGWGEPSAWSSHRT--PKASST 603

  Fly   682 E---EPTLQMGDRDTTT 695
            :   .|.||:...:.||
Zfish   604 KVPLAPELQLESLNCTT 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ihog	NP_609085.1	IG_like	59..145	CDD:214653	22/94 (23%)
		ig	265..330	CDD:278476	21/65 (32%)
		IG_like	267..348	CDD:214653	24/85 (28%)
		Ig	314..>377	CDD:299845	16/67 (24%)
		IG_like	364..437	CDD:214653	21/72 (29%)
		IGc2	365..427	CDD:197706	18/61 (30%)
		FN3	467..565	CDD:238020	21/103 (20%)
		fn3	580..655	CDD:278470	17/75 (23%)
prtga	NP_001038495.1	immunoglobulin domain	28..118		25/102 (25%)
		Ig1_Neogenin	28..118	CDD:143199	25/102 (25%)
		I-set	29..118	CDD:254352	25/102 (25%)
		immunoglobulin domain	122..211		22/95 (23%)
		I-set	124..210	CDD:254352	21/92 (23%)
		Ig	126..210	CDD:299845	21/86 (24%)
		immunoglobulin domain	222..309		26/93 (28%)
		IG_like	228..310	CDD:214653	24/85 (28%)
		IGc2	237..296	CDD:197706	20/62 (32%)
		immunoglobulin domain	314..384		19/69 (28%)
		IG_like	320..399	CDD:214653	22/78 (28%)
		Ig	332..399	CDD:299845	21/66 (32%)
		FN3	406..499	CDD:238020	21/107 (20%)
		fibronectin type III domain	406..491		20/99 (20%)
		fibronectin type III domain	504..590		20/88 (23%)
		FN3	507..597	CDD:238020	21/92 (23%)
		fibronectin type III domain	606..690		5/15 (33%)
		FN3	606..686	CDD:238020	5/15 (33%)
		fibronectin type III domain	710..794
		FN3	713..801	CDD:238020
		fibronectin type III domain	806..895
		FN3	809..901	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1060..1149
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44170
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010