DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ihog and palld

DIOPT Version :9

Sequence 1:NP_609085.1 Gene:ihog / 33972 FlyBaseID:FBgn0031872 Length:886 Species:Drosophila melanogaster
Sequence 2:XP_021324295.1 Gene:palld / 557660 ZFINID:ZDB-GENE-041014-252 Length:1401 Species:Danio rerio


Alignment Length:580 Identity:124/580 - (21%)
Similarity:205/580 - (35%) Gaps:166/580 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 SPAHPAHSAHPAHPAHP--------------AHPAHPSPGVRILRAP----ESLVAPLGDEVVLE 73
            |||....|..|..|..|              |.|...:|     |.|    :|.:....|.|:.:
Zfish   860 SPAGFLASVLPTTPPPPPMNALGLPKGNGTVALPRKTTP-----RTPRIISDSDIQGSKDAVIQD 919

  Fly    74 CETSLQ---------PERFEWSHRSSRSPGAGFKYLKTGTA-----------KANVSQEAAISRL 118
            .|..|:         .:|..:..:.:|      :.|....|           :||..:.:|.|. 
Zfish   920 LERKLRFKEERLSNGQQRLTYEEKMAR------RLLGADNAATVFNTQQVEEEANTQEGSADSE- 977

  Fly   119 RVLVRPDTLGEYRCVGWFGPLVVTSTIARLELASTSLVDAQESESPLQ----------------- 166
               ..|..  ||: |..|...:::....|||.:     ..:||:..:|                 
Zfish   978 ---SVPQK--EYK-VSSFEQRLISEIEFRLERS-----PVEESDDDVQHDEDAPGEVAPSFDQKL 1031

  Fly   167 --WRVSAGNSVLWSCGQQVQSNPSASWSYYRNGVEIK-----------PEFIGTNGNLFLSNVSS 218
              ::|..|..|.:||  :|..:|.....::::|.:|.           |:  || .:|..:..|.
Zfish  1032 KHYKVFEGMPVTFSC--KVMGDPKPKVYWFKDGKQISKRSEHYRISRDPD--GT-CSLHTAAASL 1091

  Fly   219 ESSGSYSCQATNPASGERIQLPGSLQLQ-VTPEQRSESKSP-HLLRGQPSSQ------------- 268
            :..|:|:..|.|||.  |:...|.:.:| |....||:..:| |:.|.:..|:             
Zfish  1092 DDDGNYTIMAGNPAG--RVSCTGRMMVQAVNQRGRSQRSTPGHIRRPRSRSRDSGDENENIQERH 1154

  Fly   269 ----------EITIREGSSLLLLCPGVGSPPPTVVWS------SPDVVGAVKNKRSKVFGHALEI 317
                      ::.::||....:.|...|.|.|.::|.      .||....:..:.:.|  |:|.|
Zfish  1155 FRPHFLQAPGDLIVQEGKLCRMDCKVSGLPTPDLIWQLNGQTIRPDSFHKMLVRENGV--HSLVI 1217

  Fly   318 SNTRVNDAGTYICFQDNGVRP---ALEHYIKV-HVEQPPQIVRPPWADLTNEGDRLKLECKATGV 378
            ......|||.|.|...|....   .||..:.. .:.:.|..:.........||..::|||:.:||
Zfish  1218 EPVTSRDAGVYTCIASNRAGQNSFNLELIVAAKEMHKAPSFIEKLQNTSVAEGHPVRLECRVSGV 1282

  Fly   379 PTPEIYWLLNGHSSIDDSE--AELSNNF----LILHSVLKRHAGYVQCFARNRLGEHSAGTLLQV 437
            |.|:|:|.....|...:::  :...:||    :|:...||..||:....|:|..|..|:...|.|
Zfish  1283 PFPQIFWKKENESFTHNTDRISMHQDNFGYLCMIIQPALKEDAGWYTVSAKNEAGIISSTARLDV 1347

  Fly   438 NPKQIQEPRESGGTHRPKPNQGSRQKQMYP------------------PTPPNVTRLSDE 479
            :.:..|       ||.||..:.......|.                  |.||.....||:
Zfish  1348 HAQWQQ-------THTPKLKKVRPSTSRYAALTERGLDVKAAFFPDSNPLPPGTLVESDD 1400

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ihogNP_609085.1 IG_like 59..145 CDD:214653 19/109 (17%)
ig 265..330 CDD:278476 18/93 (19%)
IG_like 267..348 CDD:214653 22/113 (19%)
Ig 314..>377 CDD:299845 16/66 (24%)
IG_like 364..437 CDD:214653 24/78 (31%)
IGc2 365..427 CDD:197706 21/67 (31%)
FN3 467..565 CDD:238020 5/31 (16%)
fn3 580..655 CDD:278470
palldXP_021324295.1 I-set 271..358 CDD:254352
I-set 442..539 CDD:254352
I-set 1025..1111 CDD:254352 21/92 (23%)
I-set 1157..1247 CDD:254352 21/91 (23%)
Ig 1273..1347 CDD:325142 22/73 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR44170
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.100

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