DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ihog and tutl

DIOPT Version :9

Sequence 1:	NP_609085.1	Gene:	ihog / 33972	FlyBaseID:	FBgn0031872	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster

Alignment Length:	970	Identity:	201/970 - (20%)
Similarity:	343/970 - (35%)	Gaps:	244/970 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 HPSPGVRILRAPESLV-APLGDEVVLECET--SLQPERFEWSHRSSRSPGAGFKYLKTGTAKANV 109
            |..|  |....||.:: ..|||.::|.|:.  :..||...:...:...|.........||
  Fly   250 HAPP--RFSVTPEDIIYVNLGDSIILNCQADGTPTPEILWYKDANPVDPSPTVGIFNDGT----- 307

  Fly   110 SQEAAISRLRVLVRPDTLGEYRCVGWFGPLVVTSTIARLELASTSLVDAQESESPLQWRVSAGNS 174
              |..||    .:|.:.:|||.|:...|...|:.| ||:.:|..:::    ...|.......|..
  Fly   308 --ELRIS----TIRHEDIGEYTCIARNGEGQVSHT-ARVIIAGGAVI----MVPPTNQTKLEGEK 361

  Fly   175 VLWSC-GQQVQSNPSASWSYYRNGVEIKP-------EFIGTNGNLFLSNVSSESSGSYSCQATN- 230
            |::|| .:.:..|.:..|  ||.|..::.       ..|..:|:|.::.:..:.||.|.|:.||
  Fly   362 VIFSCEAKAMPGNVTVRW--YREGSPVREVAALETRVTIRKDGSLIINPIKPDDSGQYLCEVTNG 424

  Fly   231 ---PASGE---RIQLPGSLQLQVTPEQ---RSESKSPHLLRGQPSSQEITIREGSSLLLLCPGVG 286
               |.|..   .::.|..:....|.:.   |........::..|..|.:|..:...||
  Fly   425 IGDPQSASAYLSVEYPAKVTFTPTVQYLPFRLAGVVQCYIKSSPQLQYVTWTKDKRLL------- 482

  Fly   287 SPPPTVVWSSPDVVGAVKNKRSKVFGHALEISNTRVND--AGTYICFQDNGVRPA-LEHYIKVHV 348
            .|     :...|:|  |....|.:|        ||||:  .|.|.|...|....| ....:.|.|
  Fly   483 EP-----YQMKDIV--VMANGSLLF--------TRVNEEHQGQYACTPYNAQGTAGASGVMDVLV 532

  Fly   349 EQPPQI-VRPPWADLTNEGDRLKLEC---KATGVPTPEIYWLLNGHSSIDDSE---AELSNNFLI 406
            .:||.. |.|........||.:::.|   :|.|...|.|.|.......:.:|:   .::|...:.
  Fly   533 RKPPAFTVEPETLYQRKVGDSVEMHCDALEAEGTERPTIKWQRQEGEQLTESQRNRIKISGGNIT 597

  Fly   407 LHSVLKRHAGYVQCFARNRLGEHSAGTLLQVNPKQIQEPRESGGTHRPKPNQGSRQKQMYPPTPP 471
            :.::.:...||.||...|.:     .||:.|....|:      ||.              |..|.
  Fly   598 IENLRREDFGYYQCVVSNEV-----ATLMAVTQLVIE------GTQ--------------PHAPY 637

  Fly   472 NVT-RLSDESVMLRWMVPRNDGLPIVIFKVQY----RMVGKRKNWQTTNDNIPYGKPKWNSELGK 531
            |:| :.::.|:.|:|:...:.|..   :|..|    |..|. .:|||.:.. |.|
  Fly   638 NITGKATESSITLQWLPGYSGGSE---YKQDYTIWFREAGV-NDWQTISVT-PSG---------- 687

  Fly   532 SFTASVTDLKPQHTYRF--------------RILAVYSNNDNKESNTSAKFYLQ-PGAALDPMPV 581
            |...::..|....||.|              :::.|.:..|...:..:.|...| |.:....||
  Fly   688 STQVTINGLASGTTYEFQVVGRNVLGDGMMSKVMTVRTLEDAPAAPRNVKAATQPPDSFFQLMP- 751

  Fly   582 PELLEIEEYSETAVVLHWSLASDADEHLITGYYAYYRPSSSAGEYF----KATIEGAH------- 635
                                    ||..:..|:..|..:.|.|...    |..::|..
  Fly   752 ------------------------DEADLLAYFDIYFHTDSRGTLVYSPPKLRVKGPKPGPPRNV 792

  Fly   636 -----ARSFKI---APLETATMYEFKLQSFSAASASEFSALKQGRTQRPKTSTTEEPTLQMG--- 689
                 :..|.|   :|||.|.:.:|  .:....:.:::..|.:|:. ||:.:......|..|
  Fly   793 SVTEVSNGFLITWQSPLERAHIVKF--YTIKYRTDAQWKTLNRGQI-RPEETQYLVKNLVGGRTY 854

  Fly   690 ------DRDTTTPSHNETFNMSP------MLTGTIGGGAV--LILLLISTC---FCVCRRRNSRS 737
                  :.:.:..|.:|.....|      .:|..:.||.:  ::.:::|.|   .|..|:|..:.
  Fly   855 YFRVLANSEKSYESSDEVKFPVPARVKHKAITAGVVGGILFFIVAIILSVCAVKICNKRKRRKQE 919

  Fly   738 RGNNPNKPRMAELRDDFV--------PLGNCS----PTKQRQRTRHIHIT--------------- 775
            :..|....|:.:.|:...        ..|:.|    |.|:.::||...:|
  Fly   920 KEFNMVACRITDARNIAANNHHLHNRSTGSISSGQVPLKKYKQTRISSLTAILIAILHWIWPPDR 984

  Fly   776 -LNPLAQQQQQALEEKNDTD------QDAPYYQRPSSYDYDPTLRRMSSSSLRRSQRTLERA--- 830
             .|..:......||:.::.|      :.....||  |.|....|.....|.|..||:|||..
  Fly   985 CTNCHSIYSSPNLEDGDEDDGGGGRRRSVSRIQR--SLDGRFVLDVEGVSKLGYSQQTLESGNVD 1047

  Fly   831 ---GGSNGSNNGNNNNLNQSAEAGSIENPG-KPGRVLMKRPRLSSRSE-NLSSGSLNSVG 885
               ||.....|.|.:..:.|.:.|.:.... ...|...:||.::|.|: :|.|.:.::.|
  Fly  1048 VVDGGLFERRNSNVSQKSSSDDGGFLSRRNFITARASWRRPLVASSSQLSLQSAADSARG 1107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ihog	NP_609085.1	IG_like	59..145	CDD:214653	22/88 (25%)
		ig	265..330	CDD:278476	17/66 (26%)
		IG_like	267..348	CDD:214653	20/83 (24%)
		Ig	314..>377	CDD:299845	19/69 (28%)
		IG_like	364..437	CDD:214653	17/78 (22%)
		IGc2	365..427	CDD:197706	15/67 (22%)
		FN3	467..565	CDD:238020	24/116 (21%)
		fn3	580..655	CDD:278470	16/93 (17%)
tutl	NP_001303307.1	V-set	137..250	CDD:284989	201/970 (21%)
		IG_like	137..229	CDD:214653
		I-set	253..341	CDD:254352	27/101 (27%)
		IGc2	268..331	CDD:197706	18/73 (25%)
		I-set	346..437	CDD:254352	21/96 (22%)
		Ig	349..437	CDD:299845	21/89 (24%)
		Ig	459..530	CDD:299845	20/92 (22%)
		IG_like	549..628	CDD:214653	18/83 (22%)
		IGc2	551..617	CDD:197706	15/65 (23%)
		FN3	633..725	CDD:238020	23/106 (22%)
		FN3	786..874	CDD:238020	15/90 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452278
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840