DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ihog and Cont

DIOPT Version :9

Sequence 1:	NP_609085.1	Gene:	ihog / 33972	FlyBaseID:	FBgn0031872	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster

Alignment Length:	934	Identity:	186/934 - (19%)
Similarity:	306/934 - (32%)	Gaps:	289/934 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 PESLVAPLGDEVVLECETSLQP-ERFEWSHRSSRSPGAGFKYLKTGTAKANVSQEAAISRLRVLV 122
            ||:.||  |||:.|||.....| ..:.|:.:       |....:..         ..|:..|||:
  Fly   580 PEAPVA--GDEIRLECMAFGYPIPSYNWTRQ-------GLPLQRNA---------YTINYGRVLI 626

  Fly   123 RPDTL----GEYRCVGWFGPLVVTSTIARLELASTSLVDAQ---ESESPLQWRVSAGNS-VLWSC 179
            ..:..    |||.|         |.|..|..|..:..::.|   :...||:..:...|| |.:.|
  Fly   627 IQNATTNDNGEYSC---------TITNPRKTLMKSIYINIQMRPQFTIPLKDMIKDYNSDVTFIC 682

  Fly   180 GQQVQSNPSASWSYYRNGVEIKPEFIGTNGNLFLSNV-------SSESSGSYSCQATNPASGERI 237
              :..:.|.|::::|:|...:.|..|..:..:...||       ..:....|.|.|.|
  Fly   683 --EAFAIPDANYTWYKNAERLDPANINRDRYIIQDNVLTIKFLEKDKDDAMYQCGAQN------- 738

  Fly   238 QLP---GSLQLQVTPEQRSESKSPHLLRGQPSSQEITIREGSSLLLLCPGVGSPPPTVVWSSP-D 298
            ||.   .|.||:|...:.|..|.|      ..|:...:..|:: .::|....:|.|...|... .
  Fly   739 QLKTSFSSAQLRVLSMKPSFKKHP------LESEVYAVYNGNT-TIVCDPEAAPRPKFQWKKDGQ 796

  Fly   299 VVGAVKNKRSKVFGHALEISNTRVNDAGTYICFQDNGVRPALEHYIKVHVEQPPQIVRPPWADLT 363
            |:|:..::|....| .|.||.|..:|.|.|.|...|.......|...:.:::...|..||...::
  Fly   797 VIGSGGHRRILPSG-TLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQRIVS 860

  Fly   364 NEGDRLKLECKATGVPTPEI--YWLLNGHSSIDDSEAELSNNF------------LILHSVLKRH 414
            .|.|.:.|.|:|......:|  .|..||.        .|.||.            |.:|:...|.
  Fly   861 KEHDLIFLHCEAAFDELLDIAYVWKHNGE--------VLKNNHDGTGRIIVDWNRLTVHNTSMRD 917

  Fly   415 AGYVQCFARNRLGEHSAGTLLQVNPKQIQEPRESGGTHRPKPNQGSRQKQMYPPTPPNVTRLSDE 479
            ||..:|..::.:.|.|:.|.:.:.    ..|...||.                    .|.::|..
  Fly   918 AGDYECVVKSAVNEISSKTSVSIE----GAPGAPGGV--------------------QVIQISKT 958

  Fly   480 SVMLRWMVPRNDGLPIVIFKVQYRMVGKRKNWQTTNDNI-PYGKPKWNSELGKSFTASVTDLKPQ 543
            ..::.|:...::|..|    ..|.::| |.||..|..|: .:.:.:..........|.|.:|.|.
  Fly   959 KAIIEWVDGSHNGRAI----RYYNILG-RTNWNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPW 1018

  Fly   544 HTYRFRILAVYSNNDNKESNTSA----------KFYLQP------GAALDPMPV--PELLEIEEY 590
            ..|.|.:.||   ||......||          |.|:.|      |..:..:.:  ..||..|::
  Fly  1019 SAYEFSVTAV---NDLGIGTPSAPSPIYSTYEDKPYIAPRNVGGGGGKIGDLTITWDPLLPQEQH 1080

  Fly   591 SETAVVLH----WSL------ASD---ADEHL--------ITGYYAYY----------------- 617
            |..   :|    |.|      |||   ..:|:        :..||..|
  Fly  1081 SHG---IHYKVFWKLKGAIEWASDEIKKQDHMGVAVVNIPLNNYYTEYEVKVQAINSVGKGPESE 1142

  Fly   618 --------------------------------RPSSSAGEYFKATIEGAHARSFK---------- 640
                                            :|...:.|..:..:.|...:.:|
  Fly  1143 IAVIHSAEDMPQVAPQKPIALAYNSTCFNVTWQPIDMSRENIRGKLIGHRLKYWKTTHQEEDSVY 1207

  Fly   641 -----------IAPLETATMYEFKLQSFSAASASEFSALKQGRTQRPKTSTTEEPTLQMGDRDTT 694
                       |..|:..|.|..|:.:::||.            :.|::...||.|.:...:  .
  Fly  1208 YLSRTTRNWALIVGLQPDTYYFVKVMAYNAAG------------EGPESERFEERTYRKAPQ--K 1258

  Fly   695 TPSHNETFNMSPMLTGTIGGGAVLILLLISTCFCVCRRRNSRSRGNNP---NKPRMAELRDDFVP 756
            .||....:.::|.....:.                  |..|.|:...|   .|.|:.|...:.:.
  Fly  1259 PPSSVHVYGINPSTVRVVW------------------RYVSPSQDEEPVEGYKVRIWESDQNMIT 1305

  Fly   757 LGNCSPTKQRQRTRHIHITLNPLAQQQQQALEEKNDTDQDAPYYQRPSSYDYDPTLRRMSSSSLR 821
            ..|               |:.|:.|:.:..:   |:......|..|..:|..... .||||.:|.
  Fly  1306 ANN---------------TIVPIGQKLESYI---NNLTPGKSYNMRVLAYSNGGD-GRMSSPTLH 1351

  Fly   822 RSQRTLERAGGSNGSNNGNNNNLN 845
            .......|    ||:|..:.:|:|
  Fly  1352 FQMGKTTR----NGANTRHGHNIN 1371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ihog	NP_609085.1	IG_like	59..145	CDD:214653	22/90 (24%)
		ig	265..330	CDD:278476	17/65 (26%)
		IG_like	267..348	CDD:214653	20/81 (25%)
		Ig	314..>377	CDD:299845	18/62 (29%)
		IG_like	364..437	CDD:214653	21/86 (24%)
		IGc2	365..427	CDD:197706	18/75 (24%)
		FN3	467..565	CDD:238020	22/98 (22%)
		fn3	580..655	CDD:278470	23/167 (14%)
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845
		I-set	362..462	CDD:254352
		Ig	466..559	CDD:299845
		IG_like	584..657	CDD:214653	23/99 (23%)
		IGc2	586..645	CDD:197706	19/83 (23%)
		Ig	667..751	CDD:299845	22/92 (24%)
		IG_like	676..751	CDD:214653	20/83 (24%)
		IG_like	765..844	CDD:214653	20/80 (25%)
		Ig	773..844	CDD:299845	19/72 (26%)
		I-set	851..940	CDD:254352	24/96 (25%)
		Ig	866..944	CDD:299845	19/89 (21%)
		FN3	944..1043	CDD:238020	27/126 (21%)
		FN3	1053..1146	CDD:238020	16/95 (17%)
		fn3	1156..1244	CDD:278470	12/99 (12%)
		fn3	1259..1346	CDD:278470	19/123 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452260
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930