DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ihog and boc

DIOPT Version :9

Sequence 1:	NP_609085.1	Gene:	ihog / 33972	FlyBaseID:	FBgn0031872	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_001005393.1	Gene:	boc / 334628	ZFINID:	ZDB-GENE-030131-6560	Length:	1032	Species:	Danio rerio

Alignment Length:	854	Identity:	194/854 - (22%)
Similarity:	307/854 - (35%)	Gaps:	251/854 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 PESLVAPLGDEVVLECETSLQPERFEWSHRSSRSPGAGFKYLKTGTAKANVSQEAAISRLRVLVR 123
            |.|:|..||..|.|.|..........| |.:.|...||                 ....|.||||
Zfish    46 PFSVVQKLGGSVTLRCSALPNHVNISW-HLNGRELPAG-----------------GDEELGVLVR 92

  Fly   124 PD----------TLGEYRCVGW--FGPLV-VTSTIARLELASTSLVDAQESESPLQWRVSAGNSV 175
            |.          |:|.|:||..  .|... |.:.:...:|......|.||.|      |..||:.
Zfish    93 PGSLYIPSLTNLTVGRYQCVATTSVGSCASVPANVTAAKLRDFEPDDQQEIE------VDEGNTA 151

  Fly   176 LWSCGQQVQSNPSASWSYYRNGVEIKPEFIGT---------NGNLFLSNVSSESSGSYSCQATNP 231
            :..| ...:|.|.|...|     .:|.|::.|         :|||.::|.:.:..|.|.|.|.||
Zfish   152 VIEC-HLPESQPKAQVRY-----SVKQEWLETSKGNYLIMPSGNLQIANATRDDEGPYICAAYNP 210

  Fly   232 ASGERIQLPGSLQLQVTPEQRSESKSPHLLRGQPSSQEITIREGSSLLLLCPGVGSPPPTVVWSS 296
            .:.|......:.:|::   :||.|::..::. .|:|:.|.:.:|..|:|.|...|.|.|.|.|:.
Zfish   211 VTQEIKTSTSTDRLRI---RRSTSEAARIIY-PPASRSIMVNKGQRLVLECVASGIPTPQVTWAK 271

  Fly   297 PDVVGAVKNKRSKVFGHALEISNTRVNDAGTYICFQDNGV--RPALEHYIKVHVEQPPQI-VRPP 358
             |.:....:..::.....|.|.....:|:|||:|..|||:  ..:.:....|.|.:|||: |...
Zfish   272 -DGLDLRNHNNTRFLLSNLLIDAASESDSGTYVCLADNGIGSTSSAQVLYDVQVFEPPQVRVELQ 335

  Fly   359 WADLTNEGDRLKLECKATGVPTPEIYWLLNGHSSIDDSEAELSNNFLILHSVLKRHAGYVQCFAR 423
            ..|:. .||.::..|:..|.|.|.:.||.|...........:|...|.:.:|..:..|..||.|.
Zfish   336 QQDVA-WGDTVRFSCQVRGKPAPTVVWLHNAQPLSPSPRHRVSAQVLRVLNVGPQDDGMYQCMAE 399

  Fly   424 NRLGEHSAGTLL----------------------------------------------QVNPKQ- 441
            |.:|...|.|.|                                              :|:|.:
Zfish   400 NGVGSSQAATRLLTLPTVPSRKMPMIRPLSPDKVLREQPPLKPPVSTSAVLPFDCSEVRVSPAEA 464

  Fly   442 ---IQEPR--------------------------------ESGGTHRPKPNQGSRQK-------- 463
               :.:||                                ||.|........||:.|
Zfish   465 PVILSQPRTGKADYYELTWKPRHDGGAPVLEYIIKYRKAGESPGEWTTNTISGSQHKLILTKLQP 529

  Fly   464 -QMY---------------------------------PPTP--------------PNVTRLSDES 480
             .:|                                 |.||              |.|:..::.|
Zfish   530 ASLYEVEMAARNCAGLGQPAMMTFRTGKWRRGGPIGPPKTPVVQPRLSPPEAPDRPTVSMATETS 594

  Fly   481 VMLRWMVPRNDGLPIVIFKVQYRMVGKRK-NWQTTNDNIPYGKPKWNSELGKSFTASVTDLKPQH 544
            ..:.|:...|.|.||..|:|:::.:.|.. :|:...:|||..:          .:..||.|:...
Zfish   595 AYVTWIPRGNRGFPIQSFRVEHKKLRKGSGDWEVAVNNIPPSR----------LSVEVTGLEKGT 649

  Fly   545 TYRFRILAVYSNNDNKESNTSAKFYLQPGAA---LDPMPVPELLEIEEYSETAVVLHWSLASDAD 606
            :|:||:|||.....:..|..| |.|...|:.   ..|:..|.:...|..:||.::|.|:. :..:
Zfish   650 SYKFRVLAVNVLGASPPSAPS-KAYTVVGSGPPNRRPIDGPYITYNEAINETTIILKWTY-TPLN 712

  Fly   607 EHLITGYYAYYRP--SSSAGEYFKATIEGA---HARSFKIAPLETATMYEFKLQSFSAASASEF- 665
            ...|.|:|.:|||  |.:..:|.|..:||.   |:    |..|:..|.|:.|:|.|:....|||
Zfish   713 NTPIYGFYIFYRPTDSDNDSDYKKDVVEGDRYWHS----ITDLQPETAYDIKMQCFNEGGESEFG 773

  Fly   666 -------SALKQGRTQRPKTSTTE-----EPTLQMGDRDTTTPSHNETFNMSPMLTGTIGGGAVL 718
                   .|....||..|:|:::.     .|..:.||             :..::.|.:.|..|.
Zfish   774 NVVILETKARPHQRTTPPETASSRPEHPGNPVPRPGD-------------LPYLIVGVVLGAFVF 825

  Fly   719 ILL-LISTC 726
            |:: .|..|
Zfish   826 IIVAFIPIC 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ihog	NP_609085.1	IG_like	59..145	CDD:214653	26/98 (27%)
		ig	265..330	CDD:278476	19/64 (30%)
		IG_like	267..348	CDD:214653	23/82 (28%)
		Ig	314..>377	CDD:299845	20/65 (31%)
		IG_like	364..437	CDD:214653	21/118 (18%)
		IGc2	365..427	CDD:197706	17/61 (28%)
		FN3	467..565	CDD:238020	28/112 (25%)
		fn3	580..655	CDD:278470	23/79 (29%)
boc	NP_001005393.1	Ig_2	40..128	CDD:290606	26/99 (26%)
		IG_like	48..128	CDD:214653	25/97 (26%)
		IG_like	140..219	CDD:214653	25/90 (28%)
		Ig	148..209	CDD:299845	18/66 (27%)
		IG_like	242..315	CDD:214653	22/73 (30%)
		Ig	243..316	CDD:299845	21/73 (29%)
		I-set	328..411	CDD:254352	24/83 (29%)
		IGc2	342..403	CDD:197706	17/60 (28%)
		ISET-FN3_linker	<422..463	CDD:293231	2/40 (5%)
		FN3	480..555	CDD:238020	7/74 (9%)
		FN3	579..674	CDD:238020	27/105 (26%)
		FN3	695..780	CDD:238020	27/89 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11449
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102649at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.880