DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ihog and Mypn

DIOPT Version :9

Sequence 1:	NP_609085.1	Gene:	ihog / 33972	FlyBaseID:	FBgn0031872	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_001355746.1	Gene:	Mypn / 309760	RGDID:	1308510	Length:	1306	Species:	Rattus norvegicus

Alignment Length:	606	Identity:	124/606 - (20%)
Similarity:	211/606 - (34%)	Gaps:	174/606 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SLLTSRLEAIPVLEKSPAHPA----HSAHPAH--PAHPAHPAHPSPG----VRILRAPESLVAPL 66
            |:|.|....:.:..|....||    :.|.|.|  ||.....|..||.    ..:...|:::...:
  Rat   680 SILNSAPPTVTISSKQVKSPAPQTFNLARPKHFFPASSTSTATVSPSSSPVFTLSNTPQTIQRTV 744

  Fly    67 GDEVVLECETSLQPERFEWSHRSSRSPGAGFKYLKTGTAKANVS-QEAAISRLRVLVRPDTLGEY 130
            ..|.:|....|.|          .||||.    |......|..| .|.|:..:...:......:.
  Rat   745 SKESLLMTHPSTQ----------GRSPGG----LSIQNEPAPPSPAEPAVPTVSYSITSGNQFQP 795

  Fly   131 RCVGWFGPLVVTSTIARLELASTSLVDAQESESPLQWRVSAGNSVLWSCGQQVQSN----PSASW 191
            .||   .|..|:.|                  ..:|..|:..:|||.|......:|    |.::.
  Rat   796 HCV---SPTPVSPT------------------GRIQNPVAFLSSVLPSLPSIPPTNAMGLPKSAP 839

  Fly   192 SYYRNGVEIK----PEFIG------TNGNLFL---SNVSSESSGSYSCQATNPASGERIQLPGSL 243
            |....|:..|    |:.:.      |..::.|   ..|:.....|:..:....:..:|:......
  Rat   840 SVPPQGLMKKTTKTPQAVSDDYIRETKNSVILDLGKKVNFSDVRSHQQEYKISSFEQRLMNEIEF 904

  Fly   244 QLQVTPEQRSESKSPH--LLRGQ-------PSSQEITIREGSSLLLLCPGVGSPPPTVVWSSPDV 299
            :|:.||...|:.:..|  :..|:       ...:...:.|||.:...|..||.|.|.|.|.....
  Rat   905 RLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGK 969

  Fly   300 VGAVKNKRSKVFGH-----ALEISNTRVNDAGTYI-----------C------------------ 330
            ..:.:|:..|:...     :|.|.:|..:|.|.|.           |
  Rat   970 QISKRNEHCKMRRDGDGTCSLHIESTHGDDDGNYTIMAANPQGRISCSGHLMVQGFPIRNRLSPA 1034

  Fly   331 ---------FQDNGVRPALEHYIKVHVEQPPQIVRPPWADL-TNEGDRLKLECKATGVPTPEIYW 385
                     .|:....|..|.:.:.|..|.|       .|: .:||...:|:||.:|:|.||:.|
  Rat  1035 GQSHRGRSRMQERDKEPLQERFFRPHFLQAP-------GDMVAHEGRLCRLDCKVSGLPPPELTW 1092

  Fly   386 LLNGHSSIDDSEAELSNNFLI----LHSVL-----KRHAGYVQCFARNRLGEHSAGTLLQVNPKQ 441
            ||||...:.|:    |:..|:    :||:|     :|.||...|.|.|:.|::|....|.|..|:
  Rat  1093 LLNGQPVLPDA----SHKMLVRETGVHSLLIDPLTQRDAGTYTCVATNKTGQNSFSLELTVVAKE 1153

  Fly   442 IQEPRESGGTHRPKPNQGSRQKQMYPPTPPNVTRLSDESVMLRWMVPRNDGLPIVIFKVQYRMVG 506
            :::                        .|..:.:|.:..|        .:|.|:   :::.|::|
  Rat  1154 VKK------------------------APVILEKLQNSGV--------PEGHPV---RLEGRVIG 1183

  Fly   507 KRK---NWQTTNDNIPYGKPK 524
            ...   .|:..|:.||:.:.:
  Rat  1184 MPPPVFYWKKDNETIPFTRER 1204

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ihog	NP_609085.1	IG_like	59..145	CDD:214653	18/86 (21%)
		ig	265..330	CDD:278476	18/80 (23%)
		IG_like	267..348	CDD:214653	22/123 (18%)
		Ig	314..>377	CDD:299845	19/101 (19%)
		IG_like	364..437	CDD:214653	29/81 (36%)
		IGc2	365..427	CDD:197706	26/70 (37%)
		FN3	467..565	CDD:238020	11/61 (18%)
		fn3	580..655	CDD:278470
Mypn	NP_001355746.1	I-set	262..348	CDD:336764
		I-set	422..519	CDD:336764
		I-set	931..1022	CDD:336764	19/90 (21%)
		I-set	1059..1149	CDD:336764	33/100 (33%)
		Ig	1175..1249	CDD:353325	6/33 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44170
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100