Protein Alignment ihog and robo1

DIOPT Version :10

• Sequence 1: NP_609085.1
• Gene: ihog / 33972
• FlyBaseID: FBgn0031872
• Length: 886
• Species: Drosophila melanogaster
• Sequence 2: XP_068069559.2
• Gene: robo1 / 30769
• ZFINID: ZDB-GENE-000209-3
• Length: 1702
• Species: Danio rerio
• Alignment Length: 792
• Identity: 183/792 - (23%)
• Similarity: 278/792 - (35%)
• Gaps: 217/792 - (27%)

  Fly    54 RILRAPESLVAPLGDEVVLECETSLQP-ERFEWSHRSSR------SPGAGFKYLKTGTAKANVSQ 111
            ||:..|..|:...|:...|.|:...:| ...||.....|      :|.:....|.||
Zfish    86 RIVEHPSDLIVSKGEPATLNCKAEGRPTPTVEWYKDGERVETDRDNPRSHRMLLPTG-------- 142

  Fly   112 EAAISRLRVL----VRPDTLGEYRCV--GWFGPLVVTSTIARLELASTSLVDAQESESPLQWRVS 170
              ::..||::    .:||. |.|.||  .:.|..|  |..|.||:|   ::.....::|:...|:
Zfish   143 --SLFFLRIVHGRRSKPDE-GSYVCVARNYLGEAV--SHNASLEVA---ILRDDFRQNPVDVMVA 199

  Fly   171 AGNSVLWSCGQQVQSNPSASWSYYRNGVEI--KPEFIG-TNGNLFLSNVSSESSGSYSCQATNPA 232
            ||...:..| |..:.:|..:.|:.::||.|  :.|.|. ..|.|.::|.....:|.|.|..|| .
Zfish   200 AGEPAVMEC-QPPRGHPEPTISWKKDGVNIDDRDERITIRGGKLMITNTRKTDAGKYVCVGTN-M 262

  Fly   233 SGERIQLPGSLQLQVTPEQRSESKSPHLLRGQPSSQEITIREGSSLLLLCPGVGSPPPTVVWSSP 297
            .|||    .|...::|..:|     |..|| :||||.:.:.:  |:...|...|.|.||:.|...
Zfish   263 MGER----ESEIAELTVLER-----PSFLR-KPSSQSVLVDQ--SVEFRCEAQGDPVPTIRWRKE 315

  Fly   298 DVVGAVKNKRSKVF-GHALEISNTRVNDAGTYICFQDNGV-RPALEHYIKVHVEQPPQIVRPPWA 360
            |  |.:...|.::: .|.|::......|||||.|..:|.: :......:.|||  ||..|..|..
Zfish   316 D--GELPKGRYEIWEDHTLKLKRLTSGDAGTYTCQAENMMGKTEASATLTVHV--PPVFVVRPRN 376

  Fly   361 DLTNEGDRLKLECKATGVPTPEIYWLLNGHSSI--DDSEAELSNNF-------LILHSVLKRHAG 416
            .:...|..:..:|:|||.|.|.|:|...|..::  .......|:.|       |.:.:|.:...|
Zfish   377 QVAGMGRTVTFQCEATGSPQPAIFWQKEGSQNLLFSSQPPPPSSRFSVSQTGDLTITAVERSDGG 441

  Fly   417 YVQCFARNRLGEHSAGTLLQV------NPKQI--QEPR--------------ESGGTHRPK---- 455
            |..|.|.|..|......||:|      .|..|  |.|.              ::.||..|.
Zfish   442 YYSCQALNIAGSVITKALLEVTDVISDRPPPIVRQGPTNQTVAVDGTVVLSCQATGTPIPTILWR 506

  Fly   456 ------PNQGSRQKQ-----------------MY------------------------------- 466
                  ....||.||                 ||
Zfish   507 KDGVLVSTHDSRLKQLDTGALQIRYAKLGDTGMYTCTASTPSGEASWKAYLEVQEFGAPVQPGRP 571

  Fly   467 --------PPTPPNVTRLSDESVMLRWMVPRNDGLPIVIFKVQYRMVGKRKNWQTTNDNIPYGKP 523
                    .|:.|:||.:|..||.|.|....|.|.....:.::........:|||..|::
Zfish   572 TDPNLIPSAPSKPDVTDVSRTSVSLSWKPNLNAGATPTSYVIEAFSHAAGSSWQTLADHV----- 631

  Fly   524 KWNSELGKSFTASVTDLKPQHTYRFRILAVYSNNDNKESNTSAKFYLQPGAALDPMPVPELLEIE 588
                   |:.:..:..|||...|.|.:.|             |..|    ...||.|:.:.::.:
Zfish   632 -------KTESFVLKGLKPSAVYLFLVRA-------------ANAY----GLSDPSPISDAVKTQ 672

  Fly   589 EYSETA--------------VVLH---------------WSLASDADEHLITGYYAYYRPSSSAG 624
            :...|:              ||:|               |::  :.....|.||...||||....
Zfish   673 DVPPTSQGVEHGQIQRELGDVVIHLHNPTILSSSSVRVQWTV--EQQSQYIQGYKVMYRPSPEGA 735

  Fly   625 ------EYFKATIEGAHARSFKIAPLETATMYEFKLQSFSAASASEFSALKQGRTQRPKTSTTEE 683
                  ..|:....|.|  |..:..|:....||||::.|........|.:|.|:|.....|....
Zfish   736 PQRVDWAMFEVGAPGEH--SAVVTQLKKGITYEFKVRPFFNEFQGTDSDIKVGKTLEEAPSAAPR 798

  Fly   684 PTLQMGDRDTTT 695
            .....|..|..|
Zfish   799 GVTVTGSGDNGT 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ihog	NP_609085.1	Ig	266..348	CDD:472250	23/83 (28%)
		Ig strand B	278..282	CDD:409353	0/3 (0%)
		Ig strand C	291..295	CDD:409353	1/3 (33%)
		Ig strand E	313..317	CDD:409353	2/3 (67%)
		Ig strand F	327..332	CDD:409353	3/4 (75%)
		Ig strand G	341..344	CDD:409353	0/2 (0%)
		Ig	352..437	CDD:472250	25/93 (27%)
		Ig strand B	369..373	CDD:409353	0/3 (0%)
		Ig strand C	382..386	CDD:409353	1/3 (33%)
		Ig strand E	404..407	CDD:409353	2/9 (22%)
		Ig strand F	417..422	CDD:409353	2/4 (50%)
		Ig strand G	430..433	CDD:409353	0/2 (0%)
		FN3	467..565	CDD:238020	22/97 (23%)
		FN3	582..>655	CDD:238020	21/107 (20%)
robo1	XP_068069559.2	None