DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ihog and cdon

DIOPT Version :9

Sequence 1:	NP_609085.1	Gene:	ihog / 33972	FlyBaseID:	FBgn0031872	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_001075097.1	Gene:	cdon / 280652	ZFINID:	ZDB-GENE-021115-4	Length:	1125	Species:	Danio rerio

Alignment Length:	1115	Identity:	254/1115 - (22%)
Similarity:	400/1115 - (35%)	Gaps:	329/1115 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TLLTS--SLLLFSLLTSRLEAIPVLEKSPAHPAHSAHPA-------HPAHPAHPAHPSPGVRILR 57
            |||.:  ::|.||.....|.|| :.:.|..|...:.|||       ....|..|:|.| ||.:.:
Zfish    18 TLLLNCPTVLSFSFRAEPLSAI-LKQGSSVHLHCTTHPATARISWLFQGQPLDPSHHS-GVELSQ 80

  Fly    58 APESLVAPLGDEVVLECETSLQP-----------------------------ERFEWSHRSSRSP 93
            ...||             ::|||                             |.|..:||.|
Zfish    81 DSLSL-------------SNLQPALTGSYQCSARSETGSIISRHARVTIADIEEFAETHRRS--- 129

  Fly    94 GAGFKYLKTGTAKANV----SQEAAISRLRV------------LVRP-----------DTLGEYR 131
               |...|..||....    |...|:.|.|:            |:.|           :..|.|:
Zfish   130 ---FTVNKGDTAVIECPLPRSNPPALPRFRIRGKWLEQSTDEYLILPSGNLQIVSVSSEHQGMYK 191

  Fly   132 CVGWFGPLVVTSTIARLELASTS-LVDAQESESPLQ---------WRVSAGNSVLWSCGQQVQSN 186
            | |.:.||   :...|:|...|. ||...||.||::         ..|....|:...|  .|..:
Zfish   192 C-GAYNPL---TRETRVEAHGTKLLVKDSESSSPVRIVYPITPRSLTVDQSGSLTLEC--VVSGS 250

  Fly   187 PSASWSYYRNGVE--IKPEFIGTNGNLFLSNVSSESSGSYSCQA-TNPASGERIQLPGSLQLQVT 248
            .|:...:.:||.|  :..:.:.::.||.|:::.....|.|||.. |:..:...:....::...|:
Zfish   251 LSSKVKWMKNGAELSLSSKRMLSHSNLVLNDIQPGDGGHYSCSVPTDRGAVVSVNYTVNVLAHVS 315

  Fly   249 PEQRSESKSPHLLRGQPSSQEITIREGSSLLLLCPGVGSPPPTVVW--------SSPDVVGAVKN 305
                       :|||......:.   |||:...|...|:|.|.:.|        |||
Zfish   316 -----------ILRGLSDQAAVA---GSSVRFTCAASGNPTPNITWLLNAAPLSSSP-------- 358

  Fly   306 KRSKVFGHALEISNTRVNDAGTYICFQDNGVRPALEHYIKVHVEQPPQ-------------IVRP 357
             |.|:.|.:|.||:|.:.|.|.|.|..|||:..| :...::.::..||             .|.|
Zfish   359 -RLKISGTSLLISSTTLQDQGIYQCMFDNGISSA-QSTGRLSIQSEPQSSSISAVPVKTQPSVHP 421

  Fly   358 PWADLTNEGDRLKLEC------KATGVPT----------------------PEIY---WLLN--- 388
            ..:|   |||.|.|..      :..|.||                      |.:|   |...
Zfish   422 IQSD---EGDELFLSMGEAALGETVGPPTERIGDRPTPEAPIIISPPQTHKPNMYDLEWRAGRDW 483

  Fly   389 ---------GHSSIDD----------------------SEAELSNNFLILHSVLKRHAGYVQCFA 422
                     .:..:||                      ||.|.|:    |:.||        ..|
Zfish   484 GIAIIAYFVKYRKVDDMGNVVGSWHTVRVPGSEKSLPLSELEPSS----LYEVL--------MVA 536

  Fly   423 RNRLGEHSAGTLLQVNPKQIQEPRESGG----THRPKPNQGSRQKQMY---------PPTP--PN 472
            |:..||.....|.....|:...|.::..    ...|:.....:....|         |..|  |.
Zfish   537 RSAAGEGQPAMLTFRTGKERASPNKNPSKAPIVSLPEKTPEDKTTNTYYGVVIHDRVPEAPDRPT 601

  Fly   473 VTRLSDESVMLRWMVPRNDGLPIVIFKVQYRMVGKRKNWQTTNDNIPYGKPKWNSELGKSFTASV 537
            ::..::.||.:.|:...|.|.||..|:|:||..|:..:|....|||        |.|  ..:..|
Zfish   602 ISMATESSVYVTWIPRANGGSPITAFRVEYRKQGRNGDWIIAADNI--------SPL--KLSVEV 656

  Fly   538 TDLKPQHTYRFRILAVYSNNDNKESNTSAKFYLQPGAA-LDPMPV--PELLEIEEYSETAVVLHW 599
            .:|:|..|||||::|:.:..::..|.||..:.:...:: :...||  |.:...:..|:|.::|.|
Zfish   657 RNLEPGSTYRFRVIAMNNYGESPASATSRPYQVSMSSSPVSNRPVTGPHISSTDAVSDTQILLRW 721

  Fly   600 SLASDADEHL-ITGYYAYYRP--SSSAGEYFKATIEGAHARSFK----IAPLETATMYEFKLQSF 657
            :....::.:. |.|:|.||||  |.:..:|.|..:||     ||    |..|:..|.|:.|:|.:
Zfish   722 TYTPSSNNNTPIQGFYIYYRPTDSDNDSDYKKDVVEG-----FKFWHMIGELQPETSYDIKMQCY 781

  Fly   658 SAASASEFS--ALKQGRTQRPKTSTTEEPTLQMGDRDTTTPSHNETFNMSPMLTGTIGGGAVLIL 720
            :....||:|  .:.:.:.::|....:..|....|.....|||  :...:..::.|.:.|..||||
Zfish   782 NDGGESEYSNVMICETKARQPPGVPSLRPITPPGFYPADTPS--QPGGLLYLIVGCVLGVMVLIL 844

  Fly   721 LL-ISTCFCVCRRRNSRSRGNNPNK-PRMAELRD---DFVPL--------------GNCSPTKQR 766
            |: |..|....|::||..:.:.||. .:.||:..   |:..|              |:.:| ...
Zfish   845 LVFIVMCLWRNRQQNSMHKYDPPNYIYQSAEMNGHVLDYSALPGSSHVNGSVHTGCGHTAP-MMP 908

  Fly   767 QRTRHIHITL-NPLAQQQQQALEEKNDTDQDAPYYQRPSSYDYDPTLRRMSSSSLRRSQRTLERA 830
            |...|:|..| |.||.           .:.....|.....:.:|.:|.:.:......|...|...
Zfish   909 QTCHHLHHKLPNGLAL-----------LNGSGGLYPAGHPHAHDTSLHQNNMEYEHPSPHHLHNG 962

  Fly   831 GG------SNGSN------NGNNNNLNQSAEAGSIENPGKP--GRVLMKRP---------RLSSR 872
            ||      .|.|:      |..|||...:...|:......|  .||..::|         .:.||
Zfish   963 GGIYTALPQNDSSDCMSCQNFCNNNRCYTKTNGTFSGGTLPLMHRVAARQPDGLEMMPLNPILSR 1027

  Fly   873 SENLSSGSLN 882
            .....|..||
Zfish  1028 CHGRDSPQLN 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ihog	NP_609085.1	IG_like	59..145	CDD:214653	26/141 (18%)
		ig	265..330	CDD:278476	21/72 (29%)
		IG_like	267..348	CDD:214653	26/88 (30%)
		Ig	314..>377	CDD:299845	22/81 (27%)
		IG_like	364..437	CDD:214653	25/137 (18%)
		IGc2	365..427	CDD:197706	22/126 (17%)
		FN3	467..565	CDD:238020	31/99 (31%)
		fn3	580..655	CDD:278470	26/83 (31%)
cdon	NP_001075097.1	Ig	30..116	CDD:299845	20/100 (20%)
		IG_like	35..116	CDD:214653	19/95 (20%)
		IG_like	131..213	CDD:214653	18/85 (21%)
		Ig	139..196	CDD:299845	10/57 (18%)
		IG_like	230..310	CDD:214653	16/81 (20%)
		IGc2	239..294	CDD:197706	14/56 (25%)
		I-set	315..399	CDD:254352	29/107 (27%)
		Ig	317..399	CDD:299845	29/94 (31%)
		FN3	456..552	CDD:238020	17/107 (16%)
		FN3	594..685	CDD:238020	32/100 (32%)
		FN3	700..797	CDD:238020	30/101 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11449
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102649at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26502
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.880