DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ihog and Dcc

DIOPT Version :9

Sequence 1:	NP_609085.1	Gene:	ihog / 33972	FlyBaseID:	FBgn0031872	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	XP_008770309.2	Gene:	Dcc / 25311	RGDID:	2492	Length:	1447	Species:	Rattus norvegicus

Alignment Length:	931	Identity:	211/931 - (22%)
Similarity:	347/931 - (37%)	Gaps:	209/931 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 PSPGVRILRAPESLVAPLGDEVVLECETSLQPER----FEW-----------SHRSSRSPGAGFK 98
            |...:..:..|...|...|..|:|.|  |.:.:|    .:|           ..|..:.|....
  Rat    36 PFTSLHFVSEPSDAVTMRGGNVLLNC--SAESDRGVPVIKWKKDGLILALGMDDRKQQLPNGSL- 97

  Fly    99 YLKTGTAKANVSQEAAISRLRVLVRPDTLGEYRC---VGWFGPLVVTSTIARLELASTSLVDAQE 160
                      :.|....||..   :||. |.|:|   :|..|.::  |..|::.:|. .|....:
  Rat    98 ----------LIQNILHSRHH---KPDE-GLYQCEASLGDSGSII--SRTAKVMVAG-PLRFLSQ 145

  Fly   161 SESPLQWRVSA--GNSVLWSCGQQVQSNPSASWSYYRNGVEIKP------EFIGTNGNLFLSNVS 217
            :||     ::|  |::||..|  :|..:|..:..:.:|..::.|      ..:..:|.|.:|.:.
  Rat   146 TES-----ITAFMGDTVLLKC--EVIGDPMPTIHWQKNQQDLNPIPGDSRVVVLPSGALQISRLQ 203

  Fly   218 SESSGSYSCQATNPAS---GERIQL-----PGSLQLQVTPEQRSESKSPHLLRGQPSSQEITIRE 274
            ...||.|.|.|.||||   |...::     || |..|:...||            ||:  :...|
  Rat   204 PGDSGVYRCSARNPASTRTGNEAEVRILSDPG-LHRQLYFLQR------------PSN--VIAIE 253

  Fly   275 GSSLLLLCPGVGSPPPTVVWSSPDVVGAVKNKRSKVFGHA-LEISNTRVNDAGTYIC---FQDNG 335
            |...:|.|...|.|||:..|...:.|..:::|:..:.|.: |.|||...:|:|||.|   :::..
  Rat   254 GKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGTYTCVVTYKNEN 318

  Fly   336 VRPALEHYIKVHVEQPPQIVRPPWADLTNEGDRLKLECKATGVPTPEIYWLLNGHSSIDDSEAEL 400
            :..:.|..:.|    ||..:..|......|...::.||..:|.|.|.:.|:.||...|.....::
  Rat   319 ISASAELTVLV----PPWFLNHPSNLYAYESMDIEFECAVSGKPVPTVNWMKNGDVVIPSDYFQI 379

  Fly   401 --SNNFLILHSVLKRHAGYVQCFARNRLGEHSAGTLLQVNPKQIQEPRESGGTHRPKPNQGSRQK 463
              .:|..|| .|:|...|:.||.|.|..|...:...|.|                |||...|  .
  Rat   380 VGGSNLRIL-GVVKSDEGFYQCVAENEAGNAQSSAQLIV----------------PKPAIPS--S 425

  Fly   464 QMYPPTPPNV--TRLSDESVMLRWMVPRNDGLPIVIFKVQYRMVGKRKNWQTTNDNIPYGKPKWN 526
            .:.|..|.:|  ..:|...|.|.|..|......|..|.|.:...|..:. :..|...|
  Rat   426 SILPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRE-RALNTTQP------- 482

  Fly   527 SELGKSFTASVTDLKPQHTYRFRILAVYSNNDNKESNTSAKFYLQPGAALDPMPVPELLEIEEYS 591
                .|...:|.:|||:..|.||::| |:.....||:...|...||...: |.|| |.|.....|
  Rat   483 ----GSLQLTVGNLKPEAMYTFRVVA-YNEWGPGESSQPIKVATQPELQV-PGPV-ENLHAVSAS 540

  Fly   592 ETAVVLHWSLASDADEHLITGYYAYYRPSSSAGEYFKATIEGAHARSFKIAPLETATMYEFKLQS 656
            .|::::.|...:.|:.. :.| |..:....|.|:.....::|.   |:|:..|:..|.|..:..:
  Rat   541 PTSILITWEPPAYANGP-VQG-YRLFCTEVSTGKEQNIEVDGL---SYKLEGLKKFTEYTLRFLA 600

  Fly   657 FSAASASEFSALKQGRTQRPKTSTTEEPTLQMGDRDTTTPS-------HNETFNMS--PMLTGTI 712
            ::          :.|    |..||.:...:.:.|..:..|.       ::.:..:|  |..:||.
  Rat   601 YN----------RYG----PGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQ 651

  Fly   713 GGGAVLILLLISTCFCVCRRRNSRSRGN----NPNKPRMAELRDDFVPLGNCSPTKQRQRTRHIH 773
            .|        ..|.:.:..|:.:| ||.    .||     .|...|..|...|....:.....::
  Rat   652 NG--------FITGYKIRHRKTTR-RGEMETLEPN-----NLWYLFTGLEKGSQYSFQVSAMTVN 702

  Fly   774 ITLNP----LAQQQQQALEEKNDTDQDAPYYQRPSS----YDYDPTLR----------------- 813
            .|..|    .|:..:..|:|....||.:..:.||.:    ..:.|.|.
  Rat   703 GTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSP 767

  Fly   814 -----RMSSSSLRRSQRTLERAGGSNG--------SNNGNNNNLNQSAEAGSIENPGKPGRVLMK 865
                 |:.|   ::...::||...|:.        :|.|....|.:||...||.:|..|......
  Rat   768 YAETVRVDS---KQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPL 829

  Fly   866 RPRLSSRSENLSSGSLNSVGV 886
            .....:...::|:..|..|||
  Rat   830 LDDFPTSGPDVSTPMLPPVGV 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ihog	NP_609085.1	IG_like	59..145	CDD:214653	22/103 (21%)
		ig	265..330	CDD:278476	22/65 (34%)
		IG_like	267..348	CDD:214653	23/84 (27%)
		Ig	314..>377	CDD:299845	17/66 (26%)
		IG_like	364..437	CDD:214653	22/74 (30%)
		IGc2	365..427	CDD:197706	20/63 (32%)
		FN3	467..565	CDD:238020	26/99 (26%)
		fn3	580..655	CDD:278470	18/74 (24%)
Dcc	XP_008770309.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44170
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010