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Protein Alignment ihog and Robo1

DIOPT Version :10

Sequence 1:	NP_609085.1	Gene:	ihog / 33972	FlyBaseID:	FBgn0031872	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	XP_017172382.1	Gene:	Robo1 / 19876	MGIID:	1274781	Length:	1687	Species:	Mus musculus

Alignment Length:	742	Identity:	165/742 - (22%)
Similarity:	270/742 - (36%)	Gaps:	181/742 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 VRILR-----APESLVAPLGDEVVLECETSLQPERFEWSHRSSRSPGAGFKYLKTGTAKANVSQE 112
            |.|||     .|..::..:|:..|:||    ||.|   .|     |.....:.|.|:...:..:.
Mouse   198 VAILRDDFRQNPSDVMVAVGEPAVMEC----QPPR---GH-----PEPTISWKKDGSPLDDKDER 250

  Fly   113 AAISRLRVLV---RPDTLGEYRCVGWFGPLVVTSTIARLELASTSLVDAQESE------------ 162
            ..|...::::   |....|:|.|||                  |::|..:|||
Mouse   251 ITIRGGKLMITYTRKSDAGKYVCVG------------------TNMVGERESEVAELTVLERPSF 297

  Fly   163 --SPLQWRVSAGNSVLWSCGQQVQSNPSASW-----SYYRNGVEIKPEFIGTNGNLFLSNVSSES 220
              .|....|:..:|..:.|..:....|:..|     ...::..||:.:.     .|.:..|::..
Mouse   298 VKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDH-----TLKIRKVTAGD 357

  Fly   221 SGSYSCQATNPASGERIQLPGSLQLQVTPEQRSESKSPHLLRGQPSSQEITIREGSSLLLLCPGV 285
            .|||:|.|.|        :.|..:...|...:..|:.||.: .:|..|.:.:  |.::...|...
Mouse   358 MGSYTCVAEN--------MVGKAEASATLTVQVGSEPPHFV-VKPRDQVVAL--GRTVTFQCEAT 411

  Fly   286 GSPPPTVVWSSPDVVGAVKNKRSKVFGHA---------------LEISNTRVNDAGTYICFQDNG 335
            |:|.|.:.|..       :..::.:|.:.               |.|:|.:.:|.|.||| |...
Mouse   412 GNPQPAIFWRR-------EGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYIC-QTLN 468

  Fly   336 VRPAL--EHYIKVH---VEQPPQIVRPPWADLTNEGD-RLKLECKATGVPTPEIYWLLNG--HSS 392
            |..::  :.|::|.   .::||.::|....:.|...| .|.|.|.|||.|.|.|.|..:|  .|:
Mouse   469 VAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTLILSCVATGSPAPTILWRKDGVLVST 533

  Fly   393 IDDSEAELSNNFLILHSVLKRHAGYVQCFARNRLGEHSAGTLLQVNP--KQIQEPRESGGTHRPK 455
            .|....:|.:..|.:........|...|.|....||.:....::|..  ..:|.||.:      .
Mouse   534 QDSRIKQLESGVLQIRYAKLGDTGRYTCTASTPSGEATWSAYIEVQEFGVPVQPPRPT------D 592

  Fly   456 PNQGSRQKQMYP--PTPPNVTRLSDESVMLRWMVPRNDGLPIVIFKVQYRMVGKRKNWQTTNDNI 518
            ||       :.|  |:.|.||.:|..:|.|.|....|.|.....:.::........:|||..:|:
Mouse   593 PN-------LIPSAPSKPEVTDVSKNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTAAENV 650

  Fly   519 PYGKPKWNSELGKSFTASVTDLKPQHTYRFRILA--VYSNNDNKESNTSAKFYLQP--GAALDPM 579
                        |:.|.::..|||...|.|.:.|  .|..:|..:.:...|....|  ...:|..
Mouse   651 ------------KTETFAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVPPTSQGVDHK 703

  Fly   580 PV-------------PELLEIEEYSETAVVLHWSLASDADEHLITGYYAYYRPSSSA---GEYFK 628
            .|             |.:|     |.::|.:||::  |.....|.||...||||.::   .|:..
Mouse   704 QVQRELGNVVLHLHNPTIL-----SSSSVEVHWTV--DQQSQYIQGYKILYRPSGASHGESEWLV 761

  Fly   629 ATIEGAHARSFKIAPLETATMYEFKLQSFSAASASEFSALKQGRTQRPKTSTTEEPTLQMGDRDT 693
            ..:......|..|..|.....||.|.:.|    .:||    ||.....|.:.|.|.......|..
Mouse   762 FEVRTPTKNSVVIPDLRKGVNYEIKARPF----FNEF----QGADSEIKFAKTLEEAPSAPPRSV 818

  Fly   694 TTPSHNETFNMSPMLTGTIGGGAVLIL 720
            |. |.|:            |.|..:::
Mouse   819 TV-SKND------------GNGTAILV 832

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.