DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ihog and Neo1

DIOPT Version :9

Sequence 1:	NP_609085.1	Gene:	ihog / 33972	FlyBaseID:	FBgn0031872	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_032710.2	Gene:	Neo1 / 18007	MGIID:	1097159	Length:	1492	Species:	Mus musculus

Alignment Length:	988	Identity:	214/988 - (21%)
Similarity:	322/988 - (32%)	Gaps:	294/988 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLTSS----------LLLFSLLTSRLEAIPVLEKSPAHPAHSAHPAHPAHPAHPAHPSPGVRILR 57
            |.|||          |||..||        :|...||..|.:.....|     |......||...
Mouse    11 LCTSSSRRCCPPPPLLLLLPLL--------LLLGRPASGAAATKSGSP-----PQSAGASVRTFT 62

  Fly    58 APESLVAPL------GDEVVLECETSLQPE-RFEWSHRSSRSPGAGFKYLKTGTAKANVSQEAAI 115
            ....||.|:      |..|:|.|....:|. ..||.              |.||. .|:..:
Mouse    63 PFYFLVEPVDTLSVRGSSVILNCSAYSEPSPNIEWK--------------KDGTF-LNLESD--- 109

  Fly   116 SRLRVLV---------------RPDTLGEYRCVGWFGPL-VVTSTIARLELASTSLVDAQESESP 164
            .|.::|.               :||. |.|:||.....| .:.|..|:|.:|......:|...|
Mouse   110 DRRQLLPDGSLFISNVVHSKHNKPDE-GFYQCVATVDNLGTIVSRTAKLTVAGLPRFTSQPEPS- 172

  Fly   165 LQWRVSAGNSVLWSCGQQVQSNPSASWSYYRNGVEIKPEFIG-TNGNLFLSNVSSESSGSYSCQA 228
               .|..|||.:.:|.......|...|...|..:.:....:. .:|.|.:||.:....|.|.|..
Mouse   173 ---SVYVGNSAILNCEVNADLVPFVRWEQNRQPLLLDDRIVKLPSGTLVISNATEGDGGLYRCIV 234

  Fly   229 TNPASGERIQLPGSLQLQVTPEQRSESKSPHLLRGQPSS-QEITIREGSSLLLLCPGVGSPPPTV 292
               .||...:.....:|:|..:.........|:|  ||| .::|   |.|.:|.|...|.|.|.|
Mouse   235 ---ESGGPPKFSDEAELKVLQDPEEIVDLVFLMR--PSSMMKVT---GQSAVLPCVVSGLPAPVV 291

  Fly   293 VWSSPDVVGAVKNKRSKVF--GHALEISNTRVNDAGTYICFQDNGVRPALEHYIKVHVEQPPQIV 355
            .|...:.|...::....|.  |..||||:...:|||||.|..||| ...:|...::.|:.||..:
Mouse   292 RWMKNEEVLDTESSGRLVLLAGGCLEISDVTEDDAGTYFCIADNG-NKTVEAQAELTVQVPPGFL 355

  Fly   356 RPPWADLTNEGDRLKLECKATGVPTPEIYWLLNGHSSIDDSEAEL--SNNFLILHSVLKRHAGYV 418
            :.|.....:|...:..||:.||.|||.:.|:.||...|.....::  .:|..:| .::|...|:.
Mouse   356 KQPANIYAHESMDIVFECEVTGKPTPTVKWVKNGDVVIPSDYFKIVKEHNLQVL-GLVKSDEGFY 419

  Fly   419 QCFARNRLGEHSAGTLLQVNPKQIQEPRESGGTHRPKPNQGSRQKQMYPPTP---PNVTR----- 475
            ||.|.|.:|...||..|.:....:..|     |..|.....:....:.|.|.   |:..|
Mouse   420 QCIAENDVGNAQAGAQLIILEHDVAIP-----TLPPTSLTSATTDHLAPATTGPLPSAPRDVVAS 479

  Fly   476 -LSDESVMLRWMVPRNDG-------------------------------------LP--IVIFKV 500
             :|...:.|.|..|.:|.                                     :|  :.||||
Mouse   480 LVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGVARERVENTSQPGEMQVTIQNLMPATVYIFKV 544

  Fly   501 ---------------------QYRMVGKRKN--------------WQT--------TNDNIPY-- 520
                                 :.::.|...|              |:|        .|..:.|
Mouse   545 MAQNKHGSGESSAPLRVETQPEVQLPGPAPNIRAYATSPTSITVTWETPLSGNGEIQNYKLYYME 609

  Fly   521 -GKPKWNSELGKSFTASVTDLKPQHTYRFRILAVYSNNDNKESNTSAKFYLQPGAALD------- 577
             |..|.......|.:.::..||....|.||::|.     ||..         ||.:..
Mouse   610 KGTDKEQDIDVSSHSYTINGLKKYTEYSFRVVAY-----NKHG---------PGVSTQDVAVRTL 660

  Fly   578 ---PMPVPELLEIEEYSETAVVLHWSLASDADEH-LITGYYAYYRPSSSAGEYFKATIEGAHARS 638
               |...|:.|.:|..:..::|:||...|...:: .||||...||.:|...:..:..:.|... |
Mouse   661 SDVPSAAPQNLSLEVRNSKSIVIHWQPPSSTTQNGQITGYKIRYRKASRKSDVTETLVTGTQL-S 724

  Fly   639 FKIAPLETATMYEFKLQSFSAASASEFSALKQGRTQRPKTSTTEEPTLQMGDRDTTTPSHNETFN 703
            ..|..|:..|.|.|::.:.:.....            |.|......|.:....:|..|....:.:
Mouse   725 QLIEGLDRGTEYNFRVAALTVNGTG------------PATDWLSAETFESDLDETRVPEVPSSLH 777

  Fly   704 MSPMLTG-------------TIGGGAVLILLLISTCFCVCRRRNSRSRGNNPNKPRMAELRDDFV 755
            :.|::|.             .:.|.|:                     |.....|....::.|:
Mouse   778 VRPLVTSIVVSWTPPENQNIVVRGYAI---------------------GYGIGSPHAQTIKVDY- 820

  Fly   756 PLGNCSPTKQRQRT-------RHIHITLN---------PLAQQQQQALEEKNDTDQ------DAP 798
                    |||..|       .|..|||.         ||  .:........||.:      :||
Mouse   821 --------KQRYYTIENLDPSSHYVITLKAFNNVGEGIPL--YESAVTRPHTDTSEVDLFVINAP 875

  Fly   799 YYQRPSSYDYDPT 811
            |...|     |||
Mouse   876 YTPVP-----DPT 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ihog	NP_609085.1	IG_like	59..145	CDD:214653	24/108 (22%)
		ig	265..330	CDD:278476	25/67 (37%)
		IG_like	267..348	CDD:214653	28/83 (34%)
		Ig	314..>377	CDD:299845	21/62 (34%)
		IG_like	364..437	CDD:214653	24/74 (32%)
		IGc2	365..427	CDD:197706	20/63 (32%)
		FN3	467..565	CDD:238020	31/191 (16%)
		fn3	580..655	CDD:278470	21/75 (28%)
Neo1	NP_032710.2	Ig1_Neogenin	65..159	CDD:143199	26/112 (23%)
		I-set	65..159	CDD:254352	26/112 (23%)
		I-set	163..250	CDD:254352	20/93 (22%)
		IGc2	177..236	CDD:197706	14/61 (23%)
		I-set	261..348	CDD:254352	32/92 (35%)
		IGc2	274..337	CDD:197706	25/63 (40%)
		I-set	352..438	CDD:254352	26/86 (30%)
		Ig4_Neogenin	368..438	CDD:212460	23/70 (33%)
		FN3	470..563	CDD:238020	12/92 (13%)
		FN3	570..659	CDD:238020	19/102 (19%)
		FN3	667..759	CDD:238020	23/104 (22%)
		FN3	770..849	CDD:214495	16/108 (15%)
		FN3	887..980	CDD:238020
		FN3	987..1082	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1072..1128
		Neogenin_C	1189..1492	CDD:284094
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1205..1237
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1266..1300
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1321..1399
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44170
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010