DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ihog and DCC

DIOPT Version :9

Sequence 1:NP_609085.1 Gene:ihog / 33972 FlyBaseID:FBgn0031872 Length:886 Species:Drosophila melanogaster
Sequence 2:NP_005206.2 Gene:DCC / 1630 HGNCID:2701 Length:1447 Species:Homo sapiens


Alignment Length:922 Identity:212/922 - (22%)
Similarity:344/922 - (37%) Gaps:199/922 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 VRILRAPESLVAPLGDEVVLECETSLQPERFEWSHRSSRSPGAGFKYLKTG--TAKANVSQEAAI 115
            :|.|..|...|...|..|:|:|           |..|.|.... .|:.|.|  .|.....::..:
Human    40 LRFLSEPSDAVTMRGGNVLLDC-----------SAESDRGVPV-IKWKKDGIHLALGMDERKQQL 92

  Fly   116 SRLRVLV---------RPDTLGEYRC---VGWFGPLVVTSTIARLELASTSLVDAQESESPLQWR 168
            |...:|:         :||. |.|:|   :|..|.::  |..|::.:|. .|....::||     
Human    93 SNGSLLIQNILHSRHHKPDE-GLYQCEASLGDSGSII--SRTAKVAVAG-PLRFLSQTES----- 148

  Fly   169 VSA--GNSVLWSCGQQVQSNPSASWSYYRNGVEIKP------EFIGTNGNLFLSNVSSESSGSYS 225
            |:|  |::||..|  :|...|..:..:.:|..::.|      ..:..:|.|.:|.:.....|.|.
Human   149 VTAFMGDTVLLKC--EVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYR 211

  Fly   226 CQATNPASGE-------RIQLPGSLQLQVTPEQRSESKSPHLLRGQPSSQEITIREGSSLLLLCP 283
            |.|.||||..       ||.....|..|:...||            ||:  :...||...:|.|.
Human   212 CSARNPASSRTGNEAEVRILSDPGLHRQLYFLQR------------PSN--VVAIEGKDAVLECC 262

  Fly   284 GVGSPPPTVVWSSPDVVGAVKNKRSKVFGHA-LEISNTRVNDAGTYIC---FQDNGVRPALEHYI 344
            ..|.|||:..|...:.|..:::|:..:.|.: |.|||...:|:|.|.|   :::..:..:.|..:
Human   263 VSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTV 327

  Fly   345 KVHVEQPPQIVRPPWADLTNEGDRLKLECKATGVPTPEIYWLLNGHSSIDDSEAEL--SNNFLIL 407
            .|    ||..:..|......|...::.||..:|.|.|.:.|:.||...|.....::  .:|..||
Human   328 LV----PPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRIL 388

  Fly   408 HSVLKRHAGYVQCFARNRLGEHSAGTLLQVNPKQIQEPRESGGTHRPKPNQGSRQKQMYPPTPPN 472
             .|:|...|:.||.|.|..|.......|.|                |||...|  ..:.|..|.:
Human   389 -GVVKSDEGFYQCVAENEAGNAQTSAQLIV----------------PKPAIPS--SSVLPSAPRD 434

  Fly   473 V--TRLSDESVMLRWMVPRNDGLPIVIFKVQYRMVGKRKNWQTTNDNIPYGKPKWNSELGKSFTA 535
            |  ..:|...|.|.|..|......|..|.|.:...|..:. :..|...|           .|...
Human   435 VVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRE-RALNTTQP-----------GSLQL 487

  Fly   536 SVTDLKPQHTYRFRILAVYSNNDNKESNTSAKFYLQPGAALDPMPVPELLEIEEYSETAVVLHWS 600
            :|.:|||:..|.||::| |:.....||:...|...||...: |.|| |.|:....|.|::::.|.
Human   488 TVGNLKPEAMYTFRVVA-YNEWGPGESSQPIKVATQPELQV-PGPV-ENLQAVSTSPTSILITWE 549

  Fly   601 LASDADEHLITGYYAYYRPSSSAGEYFKATIEGAHARSFKIAPLETATMYEFKLQSFSAASASEF 665
            ..:.|:.. :.| |..:....|.|:.....::|.   |:|:..|:..|.|..:..:::       
Human   550 PPAYANGP-VQG-YRLFCTEVSTGKEQNIEVDGL---SYKLEGLKKFTEYSLRFLAYN------- 602

  Fly   666 SALKQGRTQRPKTSTTEEPTLQMGDRDTTTPS-------HNETFNMS--PMLTGTIGGGAVLILL 721
               :.|    |..||.:...:.:.|..:..|.       ::.:..:|  |..:||..|       
Human   603 ---RYG----PGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNG------- 653

  Fly   722 LISTCFCVCRRRNSRSRGN----NPNKPRMAELRDDFVPLGNCSPTKQRQRTRHIHITLNP---- 778
             ..|.:.:..|:.:| ||.    .||     .|...|..|...|....:.....::.|..|    
Human   654 -FITGYKIRHRKTTR-RGEMETLEPN-----NLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWY 711

  Fly   779 LAQQQQQALEEKNDTDQDAPYYQRPSS----YDYDPTLR----------------------RMSS 817
            .|:..:..|:|....||.:..:.||.:    ..:.|.|.                      |:.|
Human   712 TAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDS 776

  Fly   818 SSLRRSQRTLERAGGSNG--------SNNGNNNNLNQSAEAGSIENPGKPGRVLMKRPRLSSRSE 874
               ::...::||...|:.        :|.|....|.:||...||.:|..|...........:...
Human   777 ---KQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVP 838

  Fly   875 NLSSGSLNSVGV 886
            :||:..|..|||
Human   839 DLSTPMLPPVGV 850

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ihogNP_609085.1 IG_like 59..145 CDD:214653 23/99 (23%)
ig 265..330 CDD:278476 21/65 (32%)
IG_like 267..348 CDD:214653 22/84 (26%)
Ig 314..>377 CDD:299845 16/66 (24%)
IG_like 364..437 CDD:214653 22/74 (30%)
IGc2 365..427 CDD:197706 20/63 (32%)
FN3 467..565 CDD:238020 26/99 (26%)
fn3 580..655 CDD:278470 18/74 (24%)
DCCNP_005206.2 Ig1_Neogenin 41..136 CDD:143199 26/109 (24%)
IG_like 46..136 CDD:214653 24/104 (23%)
IG_like 147..224 CDD:214653 23/83 (28%)
IGc2 153..219 CDD:197706 17/67 (25%)
I-set 241..327 CDD:254352 25/99 (25%)
Ig 244..327 CDD:299845 25/96 (26%)
I-set 331..417 CDD:254352 24/86 (28%)
Ig 347..417 CDD:299845 21/70 (30%)
FN3 429..521 CDD:238020 27/104 (26%)
FN3 528..617 CDD:238020 23/108 (21%)
FN3 625..715 CDD:238020 20/103 (19%)
FN3 726..805 CDD:214495 13/81 (16%)
FN3 846..939 CDD:238020 3/5 (60%)
FN3 946..1041 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1126..1152
Neogenin_C 1148..1445 CDD:284094
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1165..1222
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1288..1330
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1394..1419
Interaction with MYO10. /evidence=ECO:0000269|PubMed:21642953 1432..1439
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR44170
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

Return to query results.
Submit another query.