DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ihog and Dcc

DIOPT Version :9

Sequence 1:	NP_609085.1	Gene:	ihog / 33972	FlyBaseID:	FBgn0031872	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_031857.2	Gene:	Dcc / 13176	MGIID:	94869	Length:	1447	Species:	Mus musculus

Alignment Length:	927	Identity:	209/927 - (22%)
Similarity:	345/927 - (37%)	Gaps:	201/927 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 PSPGVRILRAPESLVAPLGDEVVLECETSLQPER----FEW-----------SHRSSRSPGAGFK 98
            |...:..:..|...|...|..|:|.|  |.:.:|    .:|           ..|..:.|....
Mouse    36 PFTSLHFVSEPSDAVTMRGGNVLLNC--SAESDRGVPVIKWKKDGLILALGMDDRKQQLPNGSL- 97

  Fly    99 YLKTGTAKANVSQEAAISRLRVLVRPDTLGEYRC---VGWFGPLVVTSTIARLELASTSLVDAQE 160
                      :.|....||..   :||. |.|:|   :...|.::  |..|::.:|. .|....:
Mouse    98 ----------LIQNILHSRHH---KPDE-GLYQCEASLADSGSII--SRTAKVTVAG-PLRFLSQ 145

  Fly   161 SESPLQWRVSA--GNSVLWSCGQQVQSNPSASWSYYRNGVEIKP------EFIGTNGNLFLSNVS 217
            :||     ::|  |::||..|  :|...|..:..:.:|..::.|      ..:..:|.|.:|.:.
Mouse   146 TES-----ITAFMGDTVLLKC--EVIGEPMPTIHWQKNQQDLNPLPGDSRVVVLPSGALQISRLQ 203

  Fly   218 SESSGSYSCQATNPASGERIQLPGSLQLQVTPEQRSESKSPHLLRG----QPSSQEITIREGSSL 278
            ...||.|.|.|.||||   |:.....::::..:       |.|.|.    |..|..|.| ||...
Mouse   204 PGDSGVYRCSARNPAS---IRTGNEAEVRILSD-------PGLHRQLYFLQRPSNVIAI-EGKDA 257

  Fly   279 LLLCPGVGSPPPTVVWSSPDVVGAVKNKRSKVFGHA-LEISNTRVNDAGTYIC---FQDNGVRPA 339
            :|.|...|.|||:..|...:.|..:::|:..:.|.: |.|||...:|:|||.|   :::..:..:
Mouse   258 VLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGTYTCVVTYKNENISAS 322

  Fly   340 LEHYIKVHVEQPPQIVRPPWADLTNEGDRLKLECKATGVPTPEIYWLLNGHSSIDDSEAEL--SN 402
            .|..:.|    ||..:..|......|...::.||..:|.|.|.:.|:.||...|.....::  .:
Mouse   323 AELTVLV----PPWFLNHPSNLYAYESMDIEFECAVSGKPVPTVNWMKNGDVVIPSDYFQIVGGS 383

  Fly   403 NFLILHSVLKRHAGYVQCFARNRLGEHSAGTLLQVNPKQIQEPRESGGTHRPKPNQGSRQKQMYP 467
            |..|| .|:|...|:.||.|.|..|...:...|.|                |||...|  ..:.|
Mouse   384 NLRIL-GVVKSDEGFYQCVAENEAGNAQSSAQLIV----------------PKPAIPS--SSILP 429

  Fly   468 PTPPNV--TRLSDESVMLRWMVPRNDGLPIVIFKVQYRMVGKRKNWQTTNDNIPYGKPKWNSELG 530
            ..|.:|  ..:|...|.|.|..|......|..|.|.:...|..:. :..|...|
Mouse   430 SAPRDVLPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRE-RALNTTQP----------- 482

  Fly   531 KSFTASVTDLKPQHTYRFRILAVYSNNDNKESNTSAKFYLQPGAALDPMPVPELLEIEEYSETAV 595
            .|...:|.:|||:..|.||::| |:.....||:...|...||...: |.|| |.|.....|.|::
Mouse   483 GSLQLTVGNLKPEAMYTFRVVA-YNEWGPGESSQPIKVATQPELQV-PGPV-ENLHAVSTSPTSI 544

  Fly   596 VLHWSLASDADEHLITGYYAYYRPSSSAGEYFKATIEGAHARSFKIAPLETATMYEFKLQSFSAA 660
            ::.|...:.|:.. :.| |..:....|.|:.....::|.   |:|:..|:..|.|..:..:::
Mouse   545 LITWEPPAYANGP-VQG-YRLFCTEVSTGKEQNIEVDGL---SYKLEGLKKFTEYTLRFLAYN-- 602

  Fly   661 SASEFSALKQGRTQRPKTSTTEEPTLQMGDRDTTTPS-------HNETFNMS--PMLTGTIGGGA 716
                    :.|    |..||.:...:.:.|..:..|.       ::.:..:|  |..:||..|
Mouse   603 --------RYG----PGVSTDDITVVTLSDVPSAPPQNISLEVVNSRSIKVSWLPPPSGTQNG-- 653

  Fly   717 VLILLLISTCFCVCRRRNSRSRGN----NPNKPRMAELRDDFVPLGNCSPTKQRQRTRHIHITLN 777
                  ..|.:.:..|:.:| ||.    .||     .|...|..|...|....:.....::.|..
Mouse   654 ------FITGYKIRHRKTTR-RGEMETLEPN-----NLWYLFTGLEKGSQYSFQVSAMTVNGTGP 706

  Fly   778 P----LAQQQQQALEEKNDTDQDAPYYQRPSS----YDYDPTLR--------------------- 813
            |    .|:..:..|:|....||.:..:.||.:    ..:.|.|.
Mouse   707 PSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAET 771

  Fly   814 -RMSSSSLRRSQRTLERAGGSNG--------SNNGNNNNLNQSAEAGSIENPGKPGRVLMKRPRL 869
             |:.|   ::...::||...|:.        :|.|....|.:||...||.:|..|..........
Mouse   772 VRVDS---KQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDF 833

  Fly   870 SSRSENLSSGSLNSVGV 886
            .:...::|:..|..|||
Mouse   834 PTSGPDVSTPMLPPVGV 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ihog	NP_609085.1	IG_like	59..145	CDD:214653	21/103 (20%)
		ig	265..330	CDD:278476	23/65 (35%)
		IG_like	267..348	CDD:214653	26/84 (31%)
		Ig	314..>377	CDD:299845	17/66 (26%)
		IG_like	364..437	CDD:214653	22/74 (30%)
		IGc2	365..427	CDD:197706	20/63 (32%)
		FN3	467..565	CDD:238020	26/99 (26%)
		fn3	580..655	CDD:278470	18/74 (24%)
Dcc	NP_031857.2	Ig1_Neogenin	42..136	CDD:143199	22/112 (20%)
		IG_like	46..136	CDD:214653	22/108 (20%)
		IG_like	147..224	CDD:214653	24/86 (28%)
		IGc2	153..219	CDD:197706	18/67 (27%)
		I-set	241..327	CDD:254352	26/86 (30%)
		Ig	244..327	CDD:299845	26/83 (31%)
		I-set	331..417	CDD:254352	24/86 (28%)
		Ig	347..417	CDD:299845	21/70 (30%)
		FN3	429..521	CDD:238020	27/104 (26%)
		FN3	528..617	CDD:238020	23/108 (21%)
		FN3	625..715	CDD:238020	20/103 (19%)
		FN3	726..805	CDD:214495	13/81 (16%)
		FN3	846..939	CDD:238020	3/5 (60%)
		FN3	946..1041	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1126..1153
		Neogenin_C	1148..1445	CDD:284094
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1166..1220
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1291..1329
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1394..1419
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44170
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010