DRSC/TRiP Functional Genomics Resources

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Protein Alignment ihog and Cntn1

DIOPT Version :9

Sequence 1:NP_609085.1 Gene:ihog / 33972 FlyBaseID:FBgn0031872 Length:886 Species:Drosophila melanogaster
Sequence 2:NP_476459.1 Gene:Cntn1 / 117258 RGDID:621300 Length:1021 Species:Rattus norvegicus


Alignment Length:1031 Identity:225/1031 - (21%)
Similarity:353/1031 - (34%) Gaps:293/1031 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 LLTSSLLLFSLLTSRLEAI------------------PVLEKSPAHPAHSAHPAHPAHPAHPAHP 49
            ||.|.|||.| |||.|...                  |:.|:.|.:..:                
  Rat     5 LLVSHLLLIS-LTSCLGEFTWHRRYGHGVSEEDKGFGPIFEEQPINTIY---------------- 52

  Fly    50 SPGVRILRAPESLVAPLGDEVVLECETSLQPERFEWSHRSSRSPGAGFKY-LKTGTAKANVSQEA 113
                     ||.   .|..:|.|.|             |:..||...:|: :..|.......:.:
  Rat    53 ---------PEE---SLEGKVSLNC-------------RARASPFPVYKWRMNNGDVDLTNDRYS 92

  Fly   114 AISRLRVLVRPD---TLGEYRCVGWFGPLVVTSTIARLELASTSLVDAQESESPLQWRVSAGNSV 175
            .:....|:..||   ..|.|.|:......:|.||.|.|   |...:|....|...:.:|..|..:
  Rat    93 MVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATL---SFGYLDPFPPEDRPEVKVKEGKGM 154

  Fly   176 LWSCGQQVQSNPSASWSYYRNGVEI-----KPEFIG-TNGNLFLSNVSSESSGSYSCQATNPASG 234
            :..|..........|:.:..|...:     |..|:. |||||:::||.|...|:|||..::|:..
  Rat   155 VLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVESSDRGNYSCFVSSPSIT 219

  Fly   235 ERIQLPGSLQLQVTPEQRSESKSPHLLRGQPSSQEITIR-------EGSSLLLLCPGVGSPPPTV 292
            :.: ....:.|...||:.:          :|...:|.::       .|.::.|.|..:|:|.|.:
  Rat   220 KSV-FSKFIPLIPIPERTT----------KPYPADIVVQFKDIYTMMGQNVTLECFALGNPVPDI 273

  Fly   293 VWS---SPDVVGAVKNKRSKVFGHALEISNTRVNDAGTYICFQDNGVRPALEHYIKVHVEQPPQI 354
            .|.   .|....|    .....|..|:|.|.::.|.|.|.|..:| :|...:|..:::|:..|: 
  Rat   274 RWRKVLEPMPTTA----EISTSGAVLKIFNIQLEDEGLYECEAEN-IRGKDKHQARIYVQAFPE- 332

  Fly   355 VRPPWADLTNE-----GDRLKLECKATGVPTPEIYWLLNGHSSIDDSEAELSNNFLILHSVLKRH 414
                |.:..|:     |..|...|.|||.|.|.|.||.||::.   .:.||.     |:.|...:
  Rat   333 ----WVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAY---HKGELR-----LYDVTFEN 385

  Fly   415 AGYVQCFARNRLGEHSAGTLLQV---------NPKQIQEPRESGG--------THRPKP----NQ 458
            ||..||.|.|..|...|...|::         ||.:.:.....||        ...|||    ::
  Rat   386 AGMYQCIAENAYGTIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSK 450

  Fly   459 GSRQKQMYPPTPPNVTRLSDESVMLRW--------MVPRNDGLPIVIFKVQYRMVGKRKNWQT-- 513
            |:..             |.:.|.:|.|        .:.||||.....|....|  ||..:..|  
  Rat   451 GTEW-------------LVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNR--GKANSTGTLV 500

  Fly   514 -----------TNDNIPYGK-----------PKWNSELGKSFTASVTDLKPQHT---YRFRILAV 553
                       .|.:|..|:           |..:.....||...|.|...:.|   |: |...:
  Rat   501 ITNPTRIILAPINADITVGENATMQCAASFDPSLDLTFVWSFNGYVIDFNKEITNIHYQ-RNFML 564

  Fly   554 YSNND----NKESNTSAKFYLQPGAALD------------PMPVPELLEIEEYSETAVVLHWSLA 602
            .:|.:    |.:...:.::.......:|            |...|..|.||:...|:|.|.||..
  Rat   565 DANGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALTWSRG 629

  Fly   603 SDADEHLITGYYAYYRPSSSAGEYFKA-----TIEGAHARSFKIAPLETATMYEFKLQSFSAASA 662
            |  |.|.....|.....:..:.::..|     .||| :..|.|...|.....|||::.:.:....
  Rat   630 S--DNHSPISKYTIQTKTILSDDWKDAKTDPPIIEG-NMESAKAVDLIPWMEYEFRVVATNTLGT 691

  Fly   663 SEFSALKQGRTQRPKTSTTEEPTLQMGDRDTTTPSHNETFNMSPMLTGTIGGGAVLILLLISTCF 727
            .|.|.    .:.|.||             |...|      |::|   ..:|||......|..|..
  Rat   692 GEPSI----PSNRIKT-------------DGAAP------NVAP---SDVGGGGGTNRELTITWA 730

  Fly   728 CVCRRRNSRSRGNN-----PNKPRMAELRDDFVPLGNCSPTKQRQRTRHIH----ITLNPLAQQQ 783
            .:.|..:   .|||     ..||...|   ::..:...:|    ...|::|    :|.:...|.:
  Rat   731 PLSREYH---YGNNFGYIVAFKPFDGE---EWKKVTVTNP----DTGRYVHKDETMTPSTAFQVK 785

  Fly   784 QQALEEKND----------TDQDAPYYQRPSSYDYDPTLRRMSSSSLR-RSQRTLERAGGSNGSN 837
            .:|...|.|          :.|||     ||....:..::.:|||.:. ..:..||:...|....
  Rat   786 VKAFNNKGDGPYSLIAVINSAQDA-----PSEAPTEVGVKVLSSSEISVHWKHVLEKIVESYQIR 845

  Fly   838 NGNNNNLNQSAEAGSIENPGKPGRVLMKRPRLSSRSENL--------SSGSLNSVG 885
            ....::...:|.           ||.:.....|:|.|||        ..|:.||.|
  Rat   846 YWAGHDKEAAAH-----------RVQVTSQEYSARLENLLPDTQYFIEVGACNSAG 890

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ihogNP_609085.1 IG_like 59..145 CDD:214653 19/89 (21%)
ig 265..330 CDD:278476 18/74 (24%)
IG_like 267..348 CDD:214653 21/90 (23%)
Ig 314..>377 CDD:299845 18/67 (27%)
IG_like 364..437 CDD:214653 27/77 (35%)
IGc2 365..427 CDD:197706 23/66 (35%)
FN3 467..565 CDD:238020 26/136 (19%)
fn3 580..655 CDD:278470 23/79 (29%)
Cntn1NP_476459.1 IgI_1_Contactin-1 40..134 CDD:409436 26/137 (19%)
Ig strand B 61..65 CDD:409436 2/3 (67%)
Ig strand C 74..78 CDD:409436 1/3 (33%)
Ig strand E 96..100 CDD:409436 0/3 (0%)
Ig strand F 111..116 CDD:409436 2/4 (50%)
Ig strand G 125..128 CDD:409436 2/2 (100%)
Ig2_Contactin-2-like 142..230 CDD:409392 20/88 (23%)
Ig strand B 154..158 CDD:409392 0/3 (0%)
Ig strand C 169..173 CDD:409392 1/3 (33%)
Ig strand E 194..198 CDD:409392 3/3 (100%)
Ig strand F 208..213 CDD:409392 3/4 (75%)
Ig strand G 224..227 CDD:409392 0/2 (0%)
IgI_3_Contactin-1 241..328 CDD:143259 21/91 (23%)
Ig strand B 259..263 CDD:143259 1/3 (33%)
Ig strand C 272..276 CDD:143259 0/3 (0%)
Ig strand E 293..297 CDD:143259 1/3 (33%)
Ig strand F 307..312 CDD:143259 2/4 (50%)
Ig strand G 320..323 CDD:143259 1/2 (50%)
Ig 332..408 CDD:416386 28/88 (32%)
Ig strand A 332..335 CDD:409353 1/7 (14%)
Ig strand A' 339..343 CDD:409353 0/3 (0%)
Ig strand B 347..355 CDD:409353 2/7 (29%)
Ig strand C 361..366 CDD:409353 2/4 (50%)
Ig strand C' 368..371 CDD:409353 1/2 (50%)
Ig strand E 374..379 CDD:409353 2/9 (22%)
Ig strand F 388..395 CDD:409353 3/6 (50%)
Ig strand G 399..408 CDD:409353 2/8 (25%)
Ig5_Contactin-1 413..501 CDD:409438 21/102 (21%)
Ig strand B 432..436 CDD:409438 0/3 (0%)
Ig strand C 445..449 CDD:409438 0/3 (0%)
Ig strand E 467..471 CDD:409438 0/3 (0%)
Ig strand F 481..486 CDD:409438 0/4 (0%)
Ig strand G 494..497 CDD:409438 0/2 (0%)
Ig6_Contactin 503..603 CDD:409359 14/100 (14%)
Ig strand B 522..526 CDD:409359 0/3 (0%)
Ig strand C 537..541 CDD:409359 0/3 (0%)
Ig strand E 568..572 CDD:409359 0/3 (0%)
Ig strand F 582..587 CDD:409359 0/4 (0%)
Ig strand G 595..598 CDD:409359 0/2 (0%)
FN3 612..699 CDD:238020 24/93 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 695..719 10/49 (20%)
FN3 711..803 CDD:238020 21/104 (20%)
fn3 813..895 CDD:394996 18/89 (20%)
FN3 907..991 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 55 1.000 Domainoid score I10832
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.000

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