DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ihog and dcc

DIOPT Version :10

Sequence 1:NP_609085.1 Gene:ihog / 33972 FlyBaseID:FBgn0031872 Length:886 Species:Drosophila melanogaster
Sequence 2:XP_004910421.2 Gene:dcc / 100486082 XenbaseID:XB-GENE-852874 Length:1448 Species:Xenopus tropicalis


Alignment Length:731 Identity:168/731 - (22%)
Similarity:281/731 - (38%) Gaps:139/731 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 LRAPESLVAPLGDEVVLECETSLQPER----FEW-----------SHRSSRSPGAGFKYLKTGTA 105
            |..|...|...|..|||.|  |.|.:|    .:|           ..|..:.|....        
 Frog    43 LSEPSDAVTMRGGNVVLNC--SAQSDRGAPLIKWKKDGVYLNLAVDDRRQQLPSGSL-------- 97

  Fly   106 KANVSQEAAISRLRVLVRPDTLGEYRCVGWF-GPLVVTSTIARLELASTSLVDAQESESPLQWRV 169
               :.|....||..   |||. |.|:|..:. |...:.|..|::.:|....:.:| :||     |
 Frog    98 ---LIQNVVHSRHH---RPDE-GFYQCEAFLDGVGTIVSRTAKVLVAGPLRILSQ-TES-----V 149

  Fly   170 SA--GNSVLWSCGQQVQSNPSASWSYYRNGVEIKPE----FIGTNGNLFLSNVSSESSGSYSCQA 228
            :|  |::.|..|....:..|:.||......|::.|.    .:..:|.|.:|.:.:...|.|.|.|
 Frog   150 TAFVGDTALLKCEIVGEPMPAISWQRNEEDVKVAPGDTRLLVLPSGTLQISRLQTADGGVYRCLA 214

  Fly   229 TNPASGERIQLPGSLQLQVTPEQRSESKSPHLLRGQPSSQEITIREGSSLLLLCPGVGSPPPTVV 293
            .||.|.   ::....:|::..|.....:...|.|  |.:  :...||...:|.|...|.|.||:|
 Frog   215 KNPGSS---RVGNEAELRILSESGLHRQQVFLQR--PGN--VVAVEGQDAVLECAVSGYPTPTIV 272

  Fly   294 WSSPDVVGAVKNKRSKVFGHA-LEISNTRVNDAGTYIC---FQDNGVRPALEHYIKVHVEQPPQI 354
            |...|.:..::.::..|.|.: |.|||...:|||||.|   :::.....:.:..:.|    ||:.
 Frog   273 WLQGDELVPIRTRKYSVLGGSNLLISNVTDDDAGTYTCMATYKNENTSFSADLTVMV----PPRF 333

  Fly   355 VRPPWADLTNEGDRLKLECKATGVPTPEIYWLLNGHSSIDDSEAEL--SNNFLILHSVLKRHAGY 417
            :..|......|...::.||..:|.|:|.:.|..||...|.....::  .:|..|| .::|...||
 Frog   334 LNHPANLYAYESMDIEFECAVSGKPSPTVKWTKNGEVVIPSDYFQIVGGSNLRIL-GLVKSDEGY 397

  Fly   418 VQCFARNRLGEHSAGTLLQVNPKQIQEPRESGGTHRPKPNQGSRQKQMYPPTPPNV--TRLSDES 480
            .||.|.|..|.......|.:                  |:.......:.|..|.:|  ..:|...
 Frog   398 YQCIAENEAGNIQTYAQLII------------------PDPAVPSSSVLPSAPRDVVPVLVSSRF 444

  Fly   481 VMLRWMVPRNDGLPIVIFKVQYRMVGKRKNWQTTNDNIPYGKPKWNSELGKSFTASVTDLKPQHT 545
            |.|.|..|......|..:.|.:...|.::. :..|.:.|.           :...:|.:|.|:.|
 Frog   445 VRLSWRPPVEPRGNIQTYTVYFSKQGAQRE-RAVNTSQPI-----------ALQLTVGNLAPEET 497

  Fly   546 YRFRILAVYSNNDNKESNTSAKFYLQPGAALDPMPVPELLEIEEYSETAVVLHWSLASDADEHLI 610
            |.||::| |:.....||:...|...||...: |.|| |.|::...:.|:|::.|...:.|:.. :
 Frog   498 YNFRVVA-YNEWGPGESSQPVKVGTQPELQV-PGPV-ENLQVVSTAPTSVLISWEAPAYANGP-V 558

  Fly   611 TGYYAYYRPSSSAGEYFKATIEGAHARSFKIAPLETATMYEFKLQSFSAASASEFSALKQGRTQR 675
            .||..:...:.|..|. ...::|.   .:::..|...|.|..::.:::          :.|    
 Frog   559 QGYRLFCSETFSGREQ-NIEVDGL---LYRLEGLRKFTEYSIRVLAYN----------RYG---- 605

  Fly   676 PKTSTTEEPTLQMGDRDTTTP---------SHNETFNMSPMLTGTIGGGAVLILLLISTCFCVCR 731
            |..|:.|...:.:.|..:..|         |.|...:..|..:||..|        ..|.:.:..
 Frog   606 PGVSSEEHAVVTLSDVPSAMPQNVSLEVVNSRNIKVSWLPPPSGTQNG--------FITGYKIRH 662

  Fly   732 RRNSRSRGN----NPN 743
            |:.:| ||:    .||
 Frog   663 RKTTR-RGDLETIEPN 677

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ihogNP_609085.1 Ig 266..348 CDD:472250 24/85 (28%)
Ig strand B 278..282 CDD:409353 1/3 (33%)
Ig strand C 291..295 CDD:409353 2/3 (67%)
Ig strand E 313..317 CDD:409353 1/4 (25%)
Ig strand F 327..332 CDD:409353 3/7 (43%)
Ig strand G 341..344 CDD:409353 0/2 (0%)
Ig 352..437 CDD:472250 24/86 (28%)
Ig strand B 369..373 CDD:409353 0/3 (0%)
Ig strand C 382..386 CDD:409353 0/3 (0%)
Ig strand E 404..407 CDD:409353 0/2 (0%)
Ig strand F 417..422 CDD:409353 3/4 (75%)
Ig strand G 430..433 CDD:409353 0/2 (0%)
FN3 467..565 CDD:238020 24/99 (24%)
FN3 582..>655 CDD:238020 14/72 (19%)
dccXP_004910421.2 IgI_1_Neogenin_like 39..136 CDD:409387 26/109 (24%)
Ig strand A 39..42 CDD:409387
Ig strand A' 45..51 CDD:409387 1/5 (20%)
Ig strand B 55..65 CDD:409387 5/11 (45%)
Ig strand C 70..76 CDD:409387 1/5 (20%)
Ig strand C' 78..81 CDD:409387 0/2 (0%)
Ig strand D 88..93 CDD:409387 1/4 (25%)
Ig strand E 95..101 CDD:409387 0/16 (0%)
Ig strand F 113..120 CDD:409387 3/6 (50%)
Ig strand G 125..136 CDD:409387 2/10 (20%)
Ig_3 139..216 CDD:464046 20/82 (24%)
FN3 262..780 CDD:442628 109/482 (23%)
Ig 334..417 CDD:472250 23/83 (28%)
Ig strand B 348..352 CDD:409388 0/3 (0%)
Ig strand C 361..365 CDD:409388 0/3 (0%)
Ig strand E 383..387 CDD:409388 1/3 (33%)
Ig strand F 397..402 CDD:409388 3/4 (75%)
Ig strand G 410..413 CDD:409388 0/2 (0%)
FN3 592..>1043 CDD:442628 21/109 (19%)
Neogenin_C 1150..1446 CDD:461954
Blue background indicates that the domain is not in the aligned region.

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