DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ihog and igdcc4

DIOPT Version :9

Sequence 1:	NP_609085.1	Gene:	ihog / 33972	FlyBaseID:	FBgn0031872	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	XP_002662886.2	Gene:	igdcc4 / 100141327	ZFINID:	ZDB-GENE-080327-32	Length:	1246	Species:	Danio rerio

Alignment Length:	781	Identity:	181/781 - (23%)
Similarity:	279/781 - (35%)	Gaps:	172/781 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 GVRILRAPESLVAPLGD---EVVLECETSLQPERFEWSHRSSRSPGAGFKYLKTGTAKANVSQEA 113
            |:.:...|.|:....|.   .||||.:   ||...: .|..:..|.....:|:.|..   :|:..
Zfish    18 GLSVQEKPVSVELSCGAGPVHVVLEPD---QPLLLD-CHLGASEPPLNVTWLRDGVV---LSESQ 75

  Fly   114 AISRL---RVLVRPDTL---------GEYRCVGWFGPLVVTSTIARLELASTSLVDAQESESPLQ 166
            .|..|   .:|:...:.         |.|||:.......:||....|.|||.|.. .|:.|..:
Zfish    76 TIRPLPNGSLLISAFSANGPAPAGVEGGYRCLSSSSAGALTSRTLSLHLASLSRF-LQDPEPQI- 138

  Fly   167 WRVSAGNSVLWSCGQQVQSNPSASWSYYRNGVEIKPEFIG-------TNGNLFLSNVSSESSGSY 224
              |..|.:..:.|.......||.:|...:..:....|.:.       .||.|.:..||.|..|.|
Zfish   139 --VPVGGTARFECYVDGLPTPSITWEKDQAPLPAPTESLEPSRYISLPNGVLQILEVSKEDEGLY 201

  Fly   225 SCQATNPASGERIQLPGSLQLQVTPEQRSESKSPHLLRGQPSSQEITIREGSSLLLLCPGVGSPP 289
            .|.|.|.|   |.:......|.|:|....||:.  ::...|  |..|:..|...::.|...|.|.
Zfish   202 RCVAFNSA---RKRFSQDASLTVSPGLSQESEV--VIVAPP--QNSTVVMGRPAVMECMAQGEPK 259

  Fly   290 PTVVWS-------SPDVVGAVKNKRSKVFGHALEISNTRVNDAGTYICFQDNGVRPALEHYI--- 344
            |.|.||       :.|||....|         |.|.:||.:.||.|:|   ...:|....::
Zfish   260 PFVSWSRQDGKPIATDVVVLATN---------LVIPDTRSHHAGVYVC---RANKPKTRDFVSSP 312

  Fly   345 -KVHVEQPPQIVRPPWADLTNEGDRLKLECKATGVPTPEIYWLLNGHSSIDDSEAELSN-NFLIL 407
             ::.|..||.|::.|.|...:.|:..:..|.::|.|.|.:.||.||.....::..:..| ..|::
Zfish   313 AELRVLAPPIILQSPEAVSLSRGNTARFVCNSSGDPPPALRWLKNGEPVQSNARVKTQNPGVLLI 377

  Fly   408 HSVLKRHAGYVQCFARNRLGEHSAGTLLQVNPKQIQEPRESGGTHRPKPNQGSRQKQMYPPTPPN 472
            :.:....|||.||.|.|.||...|...|.|   .::|...|                  ||...:
Zfish   378 NQLRLDDAGYYQCIAANSLGTACATAKLSV---IVREGLPS------------------PPRHVS 421

  Fly   473 VTRLSDESVMLRWMVPRNDGLPIVIFKVQY-RMVGKRKNWQTTNDNIPYGKPKWN--SELGKSFT 534
            .|..|..|.:|.|..|.::...|:.|.|.| |..|        :||:.|.....|  :||
Zfish   422 ATPHSSTSALLTWDPPEHNSDQIIGFSVHYQRTAG--------SDNMEYQFAVNNDTTEL----- 473

  Fly   535 ASVTDLKPQHTYRFRILAVYSNNDNKESNTSAKFYLQPGAALDPMPVP-ELLE----------IE 588
             .|.:|.|...|.|.::|                |...||:...:||. |:||          :.
Zfish   474 -HVKELLPHTAYTFYVVA----------------YSPMGASRPSLPVTVEMLEDVPSASPQLSLL 521

  Fly   589 EYSETAVVLHW-SLASDADEHLITGYYAYYRPSSSAGEYFKATIEGAHARSFKIAPLETATMYEF 652
            ..|.|.:.:.| .|:|......||.|...||........:...: |.:.....:..|:....|:.
Zfish   522 STSPTDIRVMWLPLSSQLSRGAITRYRIDYRALEQVDHIYSVEV-GGNETQVTLRDLKPNQAYQL 585

  Fly   653 KLQSFSAASASEFSALKQGRTQRPKTSTTEEPT-----LQMGDRDTT---TPSHNETFNMSPMLT 709
            ::.:.:.|..|:.|......|.. .|.....||     .:|.....|   .|:|.:       :|
Zfish   586 RISAGTRAGFSQSSEWASHHTPN-LTQVLFAPTELKVRAKMHSLHVTWQSPPNHTQ-------IT 642

  Fly   710 GTIGGGAVLILLLISTCFCVCRRRNSRSRGNNPNKPRMAELRDDFVPLGNCSPTKQRQRTRHIHI 774
            |                :.:..|........|..||.::|         .....|.|:|.:|..:
Zfish   643 G----------------YKLSWREADGDELTNEEKPVISE---------RIQQIKLRKRIKHHEV 682

  Fly   775 T 775
            |
Zfish   683 T 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ihog	NP_609085.1	IG_like	59..145	CDD:214653	23/100 (23%)
		ig	265..330	CDD:278476	22/71 (31%)
		IG_like	267..348	CDD:214653	23/91 (25%)
		Ig	314..>377	CDD:299845	17/66 (26%)
		IG_like	364..437	CDD:214653	22/73 (30%)
		IGc2	365..427	CDD:197706	18/62 (29%)
		FN3	467..565	CDD:238020	26/100 (26%)
		fn3	580..655	CDD:278470	18/86 (21%)
igdcc4	XP_002662886.2	Ig	36..119	CDD:299845	20/89 (22%)
		I-set	129..221	CDD:254352	23/98 (23%)
		IGc2	142..209	CDD:197706	17/66 (26%)
		Ig	237..317	CDD:299845	24/93 (26%)
		IG_like	237..317	CDD:214653	24/93 (26%)
		I-set	321..407	CDD:254352	26/85 (31%)
		Ig	324..407	CDD:299845	24/82 (29%)
		FN3	414..505	CDD:238020	32/138 (23%)
		FN3	512..606	CDD:238020	16/94 (17%)
		FN3	615..709	CDD:238020	18/101 (18%)
		FN3	727..819	CDD:238020
		FN3	824..918	CDD:238020
		SH3-WW_linker	1100..>1205	CDD:293224
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44170
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010