DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18304 and Mtcl1

DIOPT Version :9

Sequence 1:	NP_001260170.1	Gene:	CG18304 / 33969	FlyBaseID:	FBgn0031869	Length:	1901	Species:	Drosophila melanogaster
Sequence 2:	XP_006524912.1	Gene:	Mtcl1 / 68617	MGIID:	1915867	Length:	2022	Species:	Mus musculus

Alignment Length:	2083	Identity:	421/2083 - (20%)
Similarity:	710/2083 - (34%)	Gaps:	692/2083 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 PATA--STSRAASSAEDQDVAVTVKLPVPPRRHTTALDIKEVEHAITPPTRVTSSPSKTSSIPDE 178
            ||||  |..||.:.|..:..::..|.|..|                .||    ::|.:.|
Mouse    56 PATATPSAGRAPTPAAPRSPSLAGKAPPSP----------------GPP----AAPGRLS----- 95

  Fly   179 LVILSTDSLAERVRKMNLL-----KKQRSLNSRENSRERSVP--RR------EEESESTATPTPV 230
                         |:..::     |......:|.....::||  ||      .|.......||..
Mouse    96 -------------RRSGVVPGAKDKPPPGAGARSAGGAKAVPGTRRAARAGPAEPLSRVGRPTGA 147

  Fly   231 VPDRPERSKSGTSLNQLAQAEQKRAALPPKKVAVASTTTAS---------SSNSSSTSLKTSNST 286
            .|  |.....|....:.......||.:||.:.:.....|.|         :...||:.|....|.
Mouse   148 EP--PPAVAKGRKTKRGPGTPPARAVVPPARASRVPAVTLSVTSVAGCRINHTDSSSDLSDCASE 210

  Fly   287 SASNEVKVVTSTSS---SSTSSSS---VRRKEADSVASK---------EIKRQTVPAASIS-HSN 335
            ..|:|.:::.:.||   |.|.||.   :|.....|..|:         .|.....|.||.. ...
Mouse   211 PLSDEQRLLPAASSDAESGTGSSDREPIRGAPTPSSGSRGPPPGSPEPPILLAAPPVASACLGGR 275

  Fly   336 STSSTASTASKSQDTNGMQEQMKALKLELETMKTRAEKAEREKSDILLRRLASMDTASNRTAASE 400
            |:...|||.|...   |.||.:             ..:|..|::.:             .|:...
Mouse   276 SSPGGASTGSPGP---GSQEDV-------------GGRAPPERTIL-------------GTSKEP 311

  Fly   401 ALNLQQKLNEMKEQLDRVTEDKRKLNLRMKELENKGSESELRRKLQAAEQICEELMEENQSAKKE 465
            :|..|.:|..:.|                        |.||.|::       |||..||...|.|
Mouse   312 SLGEQPRLLVVAE------------------------EEELLREM-------EELRSENDYLKDE 345

  Fly   466 ILNLQAEMDEVQDTFRDDEVKAKTSLQKDLEKATKNCRILSFKLKKSDRKIETLEQERQSSFNAE 530
            :..|:|||:|::|::.:::......|:::|::|.||||||.::|:|:::|  :|:.......:.|
Mouse   346 LDELRAEMEEMRDSYLEEDGYQLQELRRELDRANKNCRILQYRLRKAEQK--SLKVAETGQVDGE 408

  Fly   531 LSNKIKKLEEELRFSNELTRKLQAEAEELRNPGKKKAPMLGVLGKSTSADAKFTRESLTRGGSQE 595
            |   |:.||::|:.:.:::.:|..|.|.:..                           .|..:::
Mouse   409 L---IRSLEQDLKVAKDVSVRLHHELETVEE---------------------------KRAKAED 443

  Fly   596 DPQHLQRELQDSIERETDLKDQLKFAEEELQRLRDRERKRVRFSCGTQTEVPLEVVAFPRGTQTV 660
            |.:.|::::   ||.|.    ..:..:.|::|||:...||                   ||:
Mouse   444 DNETLRQQM---IEVEV----SRQALQNEVERLRESSLKR-------------------RGS--- 479

  Fly   661 ATVQSDMSTSVENLVTSNVAVTQTDFEVPDRNVSIERETMSSPFAGLFPPSSSSRVGQSGSLLFP 725
                                          |.:..|::.                |.|:|.:..|
Mouse   480 ------------------------------REMYKEKKL----------------VNQNGGVERP 498

  Fly   726 SAISHVLLSGAGRKLSPTPHPHRLAPEVHADRDEGI-SDEDDPAELRILLELNEQEASILRLKVE 789
                       |...|.|....:|||.........| :.:||.|:|:..|:..::|||::|.|:.
Mouse   499 -----------GNCRSATKTQRKLAPRRKITLPRAILAWQDDSADLKCQLQFVKEEASLMRKKMA 552

  Fly   790 DLEKENAESKKYVRELQAKLRQDSSNGSKSSLLSLGTSSSAAEKKVKTLNEELVQLRRTLTEKEQ 854
            .|.:|..|.:   :|||   :..|..|...|.|..|.:......:     |..::||..|.|:|.
Mouse   553 KLGREKDELE---QELQ---KYKSLYGDVDSPLPTGEAGGPPSTR-----EAELKLRLKLVEEEA 606

  Fly   855 TVDSLKNQLSKLDTLETENDKLAKENKRLLALRKASEKTG--EVDQKMKESLAQAQRERDELTAR 917
            ::..     .|:..||.||..|..|.:. :.::...|.||  .|..........:.....||...
Mouse   607 SILG-----RKIVELEVENRGLKAEMED-IRVQHEREGTGRDHVPSTPTSPFGDSMESSTELRRH 665

  Fly   918 LKRMQLEAEDKLPPRTAKRVNDLTPKSHLKKWVEELEDEISEMRVMLS--------SSG--TDQL 972
            |:.::.|||                  .|::.:.|:||...::...||        .||  .|.:
Mouse   666 LQFVEEEAE------------------LLRRSISEIEDHNRQLTHELSKFKFEPHQESGWLGDGV 712

  Fly   973 KALQSAKGALEEDLRKCKQKLSLAEGDVQRLKLLNGSSSKVSELEQKLKRGDEEA----KKLNSK 1033
            ....:|...|:|:|:..:.::....|.|.:|:..|      ..|....:|||..|    :..:.:
Mouse   713 SKGPAASVPLQEELKSARLQIDELSGKVLKLQCEN------RLLLSNAQRGDLAAHLGLRAPSPR 771

  Fly  1034 LKDLEDKVKKQEAQLKLGETSKST------WESQSKREKEKLSSLEKDMEKQAKEKEKLEAKISQ 1092
            ..|.|....|:|:..:.|...:..      .||.|:...||.|........:|.|....|....:
Mouse   772 DSDAESDAGKKESDGEEGRLPQPKREGPVGGESDSEDMFEKTSGFGSGKPSEASEPCPAELLRVR 836

  Fly  1093 LDAE-LLSAKKSAEKSKSSLEKEIKD-------------------LKTKASKSDSKQVQDLKKQV 1137
            .|.| |::.|..|::.:.::|:.|.|                   ::....:.:|.....|   :
Mouse   837 EDTECLVTIKLEAQRLERTVERLISDTDGFIHDSGLRGNGLASPGVQGGGGEGNSPSEPHL---L 898

  Fly  1138 EEVQASLSAEQKRYEDLNNHWEKLSE--ETILMRAQLTTEKQSLQAELNASKQKIAEMDTIRIER 1200
            |.:...:.|.:|   :|....|::|.  :.:...:.||.....|....:.|:.  :.:.|
Mouse   899 ETINVRMKAFRK---ELQAFLEQMSRIVDGLSPLSHLTESSSFLSTVTSVSRD--SPIGT----- 953

  Fly  1201 TDMARKLSEAQKRIADLQAKALKTVNGNGAEYERTVLKNKLAEKEHEYERLRRENEMNIDLVFQL 1265
              :.::|.      .|||:|..:.:     |::    .|:....|.|..|||...|::      .
Mouse   954 --LGKELG------PDLQSKLREQL-----EWQ----LNQDRGDEREGLRLRATRELH------R 995

  Fly  1266 RKDNDD-----LNGKLSDYN--------------RIEQAQSSLNGHGARREAE--------IREL 1303
            |.|.|.     |.|: |.:|              .:|:.|..|. ..||...|        ||::
Mouse   996 RADGDSGSHHGLGGQ-SCFNLELRGSPVLPEQSVSVEELQGQLE-QAARLHQEETETYTNKIRKM 1058

  Fly  1304 KEQ----LQSTELQMKSEVA--TVRLRYEQQVKN-LSGELTSMQRQCERF-KKDRDAFKQMLEVA 1360
            :|.    |:..||:|.|...  |:..|.....|| |..||.|:::....| .|.|...|...:..
Mouse  1059 EEDHLYALRWKELEMHSLALQNTLHKRTWSDEKNLLQQELRSLKQNIFLFYVKLRWLLKHWRQGK 1123

  Fly  1361 QKKIG--DLK-----ANNTGRQSRG--SMHSSD-----DDDKSKIAYLEQQIGHLEDQLVE--SR 1409
            |.:.|  ||:     .|..|....|  .:|.:|     |.|:.....:.:...|...|:.|  ||
Mouse  1124 QMEEGGEDLEESEHPENVPGLAELGVQGVHQTDGIDQEDADQGCSLPMGEHAPHSLVQISEHGSR 1188

  Fly  1410 LESS--------------------------------------KIKTELVSERSANEIKISEMQSK 1436
            |:||                                      :::.:..|:::|.:::.:.::.:
Mouse  1189 LQSSDGGPLNKQVVENQQLFRALKALLEDFRSELREDEHARLRLQQQYASDKAAWDVEWAVLKCR 1253

  Fly  1437 LNEFEE--ERVIGSGSTKLPGMKTKLELSWQKEREDQQRLLQETSTLARDLRQTLFEVERERDKE 1499
            |.:.||  |:.:|...:...| |..|    :||||..|:||.::.:|..|||..:...|:..::|
Mouse  1254 LEQLEEKTEKSLGELDSSAEG-KGAL----KKEREVHQKLLADSHSLVMDLRWQIHHREKNWNRE 1313

  Fly  1500 RLESKRKLDQIKRATEEEMEEGRKKIAELQCDLLELRDVHAKLRTSNEKLRRERERYEKELIKRR 1564
            ::|...:||      .|..|.||:|                      |:|....|:.:||...||
Mouse  1314 KVELLERLD------SERQEWGRQK----------------------EELLWRVEQLQKEKSPRR 1350

  Fly  1565 MEADGGDRKVGALLQTVDELVKIAPDLKIVGSGGSARSSSSSGYDKNLRPEQPNVRRSRSPS--P 1627
            .         |:.|                   .|.|...:..|     |.|.::..||..|  |
Mouse  1351 S---------GSFL-------------------CSRREDDTRPY-----PHQGSLHSSRPVSMWP 1382

  Fly  1628 TLSSSQI---TSVLARLAE-----ASEELRKFQRVNEDE-----------QERSRMRRSNLRRAA 1673
            ...:..|   ...|::|.|     |||.|.......:|:           .|....|:.||:||.
Mouse  1383 CEDADSIPFEDRPLSKLKESDRCSASENLYLDALSLDDDPGDPPPLRNCLAEEEESRKGNLQRAV 1447

  Fly  1674 S----------QENDPHGSTSSVASAAGSQRGGGRLSRNS--------SNNGSLIRKSLSLDHSI 1720
            |          .:..|......:.||...:.....||.:.        ||:..........|
Mouse  1448 SVSCMSEFQRLMDVSPFLPEKGLPSAGSKEDVTPPLSPDDLKYIEEFHSNDWDYASPRAEAD--- 1509

  Fly  1721 QRDQNIW--RQDDGSV------------------------SSMQS------------IDSELGG- 1746
             |..:.|  |.:.|.|                        .:|.|            :.:|..|
Mouse  1510 -RPPDPWADRTEMGRVGHEATTEPCPDPSWYLTTSVTMTTDTMTSPEHCQKQPLRTHVLTEQSGV 1573

  Fly  1747 -LVRDSSLDSRLDSRLSGGSTQSDI-PRG------------------------------PRKKKK 1779
             ::.......|:||..|||..:|.. |.|                              ||..:.
Mouse  1574 HVLHSPPAIRRVDSIASGGEGRSRADPEGPFPMSRARGNLADAKGGHPEPVLNRWPCTPPRHPRD 1638

  Fly  1780 GIMGKLRSLTK--------SSRNSESEISIQGSDSDISVASDMRSS---------KKDLRGRLSG 1827
            .:.|.||.|.:        :|..:..::|...||....||..:|::         .:|:..:.:|
Mouse  1639 CVEGSLRPLDRPICPSLGFASPLNSLDMSKNMSDDMKEVAFSVRNAICAGPAEPHVRDMACQTNG 1703

  Fly  1828 MFKRSGSASRSESMERAGSDQRPVAVTVVGHPDGPQPREPPPANSLTPRPIRSIPKPPSAGAPTT 1892
                          .|....|....::|     |.| .|...|:.:|..|.:.:  .|.||..||
Mouse  1704 --------------SRTAGTQTIQTISV-----GLQ-TEALRASGVTSSPHKCL--TPKAGGGTT 1746

  Fly  1893 PTT 1895
            |.:
Mouse  1747 PVS 1749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18304	NP_001260170.1	Smc	404..1202	CDD:224117	170/842 (20%)
		CENP-F_N	1012..1286	CDD:287456	61/324 (19%)
		ATP-synt_B	<1180..1231	CDD:304375	7/50 (14%)
		LCD1	1485..>1594	CDD:286837	21/108 (19%)
Mtcl1	XP_006524912.1	PHA03247	<13..317	CDD:223021	65/329 (20%)
		Smc	<337..693	CDD:224117	107/508 (21%)
		SOGA	529..623	CDD:371492	31/109 (28%)
		SOGA	658..750	CDD:371492	23/115 (20%)
		Smc	<1186..>1345	CDD:224117	39/191 (20%)
		DUF4482	1297..1418	CDD:373316	39/181 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4787
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15742
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.960