Protein Alignment CG18304 and MTCL3

DIOPT Version :10

• Sequence 1: NP_001260170.1
• Gene: CG18304 / 33969
• FlyBaseID: FBgn0031869
• Length: 1901
• Species: Drosophila melanogaster
• Sequence 2: NP_001387194.1
• Gene: MTCL3 / 387104
• HGNCID: 21494
• Length: 947
• Species: Homo sapiens
• Alignment Length: 1144
• Identity: 232/1144 - (20%)
• Similarity: 396/1144 - (34%)
• Gaps: 402/1144 - (35%)

  Fly   116 PATASTSRAASSAEDQDVAVTVKLPVPPRRHTTALDIKEVEHAITPPTRVTSSPSKTSSIPDELV 180
            ||||:.|.||::.|             .|.|......|: :.|.:|.....||..:|
Human    11 PATAAASPAAAATE-------------ARLHPEGSSRKQ-QRAQSPARPRDSSLRQT-------- 53

  Fly   181 ILSTDSLAERVRKMN-----LLKKQRSLNSRENSR--------------ERSVPRREE------- 219
            |.:|.|......|:|     .|::|:...::..||              |::.|...:
Human    54 IAATRSPVGAGTKLNSVRQQQLQQQQQQGNKTGSRTGPPASIRGGGGGAEKATPLAPKGAAPGAV 118

  Fly   220 ------ESESTAT--------PTPVVPDRPERSKSGTSLNQLAQAEQKRAALPP----------- 259
                  |:...||        |.|  |:.|.|        :|.....|....||
Human   119 QPVAGAEAAPAATLAALGGRRPGP--PEEPPR--------ELESVPSKLGEPPPLGEGGGGGGEG 173

  Fly   260 -------------------------KKVAV-----ASTTTASSSNSSSTSLKTSNSTSASNEVKV 294
                                     |.|..     :....||.|.|||::.||. .|.:.|....
Human   174 GGAGGGSGEREGGAPQPPPPRGWRGKGVRAQQRGGSGGEGASPSPSSSSAGKTP-GTGSRNSGSG 237

  Fly   295 VTSTSSSSTSSSSVRRKEADSVASKEIKRQTVPAASISHSNSTSSTASTASKSQDTNGMQEQMKA 359
            |....|....|..........:....:|::...||:.:......:...::|:|...:|.....:.
Human   238 VAGGGSGGGGSYWKEGCLQSELIQFHLKKERAAAAAAAAQMHAKNGGGSSSRSSPVSGPPAVCET 302

  Fly   360 LKL-ELETMKTRAE----KAEREKSDILLRRLASMDTASNRTAASEALNLQQKLNEMKEQLDRVT 419
            |.: ....|...||    .||...|.      ..|..|:..::......||:: .||:|::
Human   303 LAVASASPMAAAAEGPQQSAEGSASG------GGMQAAAPPSSQPHPQQLQEQ-EEMQEEM---- 356

  Fly   420 EDKRKLNLRMKELENKGSESELRRKLQAAEQICEELMEENQSAKKEILNLQAEMDEVQDTFRDDE 484
                                             |:|.|||::.|.||..|:.||||::|||.:::
Human   357 ---------------------------------EKLREENETLKNEIDELRTEMDEMRDTFFEED 388

  Fly   485 VKAKTSLQKDLEKATKNCRILSFKLKKSDRKIETLEQERQSSFNAELSNKIKKLEEELRFSNELT 549
            ......::.:||:|.||||||.::|:|::||  .|...:....:.||   ::.||::|:.:.:::
Human   389 ACQLQEMRHELERANKNCRILQYRLRKAERK--RLRYAQTGEIDGEL---LRSLEQDLKVAKDVS 448

  Fly   550 RKLQAEAEELRNP--------GKKKAPMLGV-LGKSTSAD--AKFTRESLTRGGSQEDPQHLQRE 603
            .:|..|.|.:...        .|.:..::.| :.|....:  .|....||.|.||::.|:..::.
Human   449 VRLHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKA 513

  Fly   604 LQDSIERET-DLKDQLKFAEEELQRLR------DRERKRVRFSCGTQTEVPLEVVAFPRGTQTVA 661
            .|...|.:. |||.||:|.:||...:|      |:|:.|                 |....|...
Human   514 QQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDR-----------------FEHELQKYR 561

  Fly   662 TVQSDMSTSVENLVTSNVAVTQTDFEVPDRNVSIERETMSSPFAGLFPPSSSSRVGQSGSLLFPS 726
            :...|:                 |..:|...            || .|||:..
Human   562 SFYGDL-----------------DSPLPKGE------------AG-GPPSTRE------------ 584

  Fly   727 AISHVLLSGAGRKLSPTPHPHRLAPEVHADRDEGISDEDDPAELRILLELNEQEASILRLKVEDL 791
                                                     |||::.|.|.|:||:||..|:.:|
Human   585 -----------------------------------------AELKLRLRLVEEEANILGRKIVEL 608

  Fly   792 EKENAESKKYVRELQAK---LRQDSSNGSKSSLLSLGTSSSAAEKKVKTLNEELVQLRRTLTEKE 853
            |.||       |.|:|:   ||.|..|||.:.|:             :..:|.|.:||:.|...|
Human   609 EVEN-------RGLKAELDDLRGDDFNGSANPLM-------------REQSESLSELRQHLQLVE 653

  Fly   854 QTVDSLKNQLSKLDTLETENDKLAKENKRLLA-LRKASEKTGEVD----------QKMKESLAQA 907
            ...:.|:..::.|:          ::|||:.| |.|...|:|..|          :.::|.|..|
Human   654 DETELLRRNVADLE----------EQNKRITAELNKYKYKSGGHDSARHHDNAKTEALQEELKAA 708

  Fly   908 QRERDELTARLKRMQLEAEDKL------------------PPRTAKRVNDLTPKS--------HL 946
            :.:.:||:.::  |||:.|:::                  .||.:...:|...|.        |.
Human   709 RLQINELSGKV--MQLQYENRVLMSNMQRYDLASHLGIRGSPRDSDAESDAGKKESDDDSRPPHR 771

  Fly   947 KK----WVEELEDEISEMRVMLSSSGTDQLKALQSAKGALEEDLRKCKQKLSLAEGDVQRL---- 1003
            |:    ..|...:|:..:|.:..:      ::...|.|...:.... :|::.....:.:||
Human   772 KREGPIGGESDSEEVRNIRCLTPT------RSFYPAPGPWPKSFSD-RQQMKDIRSEAERLGKTI 829

  Fly  1004 -KLLNGSSSKVSELEQKLKRGDEEAKKLNSKLKDLEDKVKKQEAQLKLGETSKSTWESQSKREKE 1067
             :|:..:|:.::|....:..||...      |.|.||                   :....||.|
Human   830 DRLIADTSTIITEARIYVANGDLFG------LMDEED-------------------DGSRIREHE 869

  Fly  1068 KLSSLEKDMEKQAKEKEKLEAKISQLDAELLSAKKSAEK 1106
            .|..:...|:...||   |:..|.:|:....:..:.||:
Human   870 LLYRINAQMKAFRKE---LQTFIDRLEVPKSADDRGAEE 905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18304	NP_001260170.1	SMC_prok_B	<354..1093	CDD:274008	169/810 (21%)
		SMC_prok_B	831..>1544	CDD:274008	61/322 (19%)
		PHA03307	1657..>1901	CDD:223039
MTCL3	NP_001387194.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..251		54/272 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	266..368		24/145 (17%)
		SMC_prok_B	<367..673	CDD:274008	102/440 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..524		8/27 (30%)
		SOGA	521..615	CDD:463264	38/200 (19%)
		SOGA	641..729	CDD:463264	25/99 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	743..786		7/42 (17%)