DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18304 and soga3b

DIOPT Version :9

Sequence 1:	NP_001260170.1	Gene:	CG18304 / 33969	FlyBaseID:	FBgn0031869	Length:	1901	Species:	Drosophila melanogaster
Sequence 2:	XP_005162464.1	Gene:	soga3b / 336052	ZFINID:	ZDB-GENE-081022-198	Length:	807	Species:	Danio rerio

Alignment Length:	944	Identity:	185/944 - (19%)
Similarity:	342/944 - (36%)	Gaps:	325/944 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 SSSTSSSSVRRKEADSVASKEIKRQTVPAASISHSNSTSSTAS-TASKSQDTNGMQEQMKALKLE 363
            ||:..:...||......::|       ||.:...|.|.||||| ..:||
Zfish    15 SSADGTEGRRRPSPGQTSAK-------PALNPRGSRSASSTASKPGAKS---------------- 56

  Fly   364 LETMKTRAEKAEREKSDILLRRLASMDTASNRTAASEALNLQQKLNEMKEQLDRVTEDKRKLNLR 428
                 |:..:.|::...:.||..|::     |.|.:||      :.|.:|::||......:..||
Zfish    57 -----TKGREGEQDTRVVKLRGAAAV-----RGAETEA------ILETEERIDRAPPPDTRRALR 105

  Fly   429 M-----------------------------------------------------KELENKG---- 436
            .                                                     |.|...|
Zfish   106 FPCVKRDSSAEKLDGAPGGVRGGQAAAGGEYVGCGPAFWGGGCLQSELIQYHINKRLRKSGRMQR 170

  Fly   437 -------------SESELRRKLQAAEQICEELMEENQSAKKEILNLQAEMDEVQDTFRDDEVKAK 488
                         :|..:.::.:|.::..|.|.:||...|..|..::.||:|::|||.:::....
Zfish   171 QTPGETQPGSGAQAEEVMTQQDEALQEEIERLEDENDELKSTIEEMRTEMEEMRDTFYEEDTCQL 235

  Fly   489 TSLQKDLEKATKNCRILSFKLKKSDRKIETLEQERQSSFNAELSNKIKKLEEELRFSNELTRKLQ 553
            ..::::||:|.||||||.::|:|::||  .|...:....:.:|   ::.||::|:.:.:::.:|.
Zfish   236 DEMRRELERANKNCRILQYRLRKAERK--RLRYAQTGEIDEDL---LRSLEQDLKVAKDVSVRLH 295

  Fly   554 AEAEELRNPGKK----------KAPMLGVLGKSTSADAKFTRESLTRGGSQEDPQHLQRELQDSI 608
            .|.|.:.....|          |...:.|..::...:....:||..|.|| :|.|..:|:.|...
Zfish   296 HELENVEEKRTKTEDENERLRQKLIEVEVTKQALQLELDKAKESQKRRGS-KDAQKPERKTQTPT 359

  Fly   609 ERET-DLKDQLKFAEEELQRLR------DRERKRVRFSCGTQTEVPLEVVAFPRGTQTVATVQSD 666
            |.:: |||.||.|.:||...:|      |:|:.|:.                 :..|...:...|
Zfish   360 EEDSEDLKCQLAFIKEEATLMRKKMAKIDKEKDRLE-----------------QELQKYRSFYGD 407

  Fly   667 MSTSVENLVTSNVAVTQTDFEVPDRNVSIERETMSSPFAGLFPPSSSSRVGQSGSLLFPSAISHV 731
            :.
Zfish   408 LD--------------------------------------------------------------- 409

  Fly   732 LLSGAGRKLSPTPHPHRLAPEVHADRDEGISDEDDPAELRILLELNEQEASILRLKVEDLEKENA 796
                       :|||...|......|:         :||::.|.|.|:||:||..|:.:||.||
Zfish   410 -----------SPHPKGEAGGPPTTRE---------SELKLRLRLVEEEANILGRKIVELEVEN- 453

  Fly   797 ESKKYVRELQAKL----RQDSSNGSKSSL-----LSLGTSSSAAEKKVKTLNEELVQLRRTLTEK 852
                  |.|:|:|    ..:||||..|..     ...|:..|...::::.:.:|...|||.|.:.
Zfish   454 ------RGLRAELDDLRGDESSNGGLSGAEGGIGREQGSELSELRQQLQLVEDEAELLRRNLADV 512

  Fly   853 EQTVDSLKNQLSKLDTLE--------------------TENDKLAKENKRLLALRKASEKTGEVD 897
            |:....:.::|:||...|                    ::::.|.:|.|  .|.::.:|.:|:|
Zfish   513 EEQNKRVTSELNKLRFKEGTRHASGSNATGSNNGGGDSSKSEALQEELK--AARKQINELSGKV- 574

  Fly   898 QKMKESLAQAQRERDELTARLKRMQLEAEDKLPPRTAKRVNDLTP-----------------KSH 945
                   .|.|.|...|.:.::|..|.:...:.||.:...:|..|                 ..|
Zfish   575 -------MQLQYENRVLLSNMQRYDLASHLAVTPRDSDAESDGGPAIGGRRGSDDDSSSSRLPPH 632

  Fly   946 LKK----WVEELEDEISEMRVMLSSSGTDQLKALQSAKGALEEDLRKCKQKLSLAEGDVQRL--- 1003
            .|:    ..|...:|:...|.:   :.|..|.:.:||: .|...:|..:|.:.: ..:.:||
Zfish   633 RKREGPVGGESDSEEVRNARCL---TPTRSLYSPESAR-LLSRSIRDRQQMIDI-RAEAERLGRT 692

  Fly  1004 --KLLNGSSSKVSELEQKLKRGDEEAKKLNSKLKDLED--KVKKQEAQLKLGETSKSTWESQSKR 1064
              :|:..:|:.::|....:..||     |..:::|.:|  ::::.|...::        .||.|.
Zfish   693 IDRLIADTSNIIAEARVFVANGD-----LFGRMEDEDDGGRIREHELLFRI--------NSQMKT 744

  Fly  1065 EKEKLSSLEKDMEKQAKEKEKLEAKISQLDAELL 1098
            .:::|......:|....|:...|..:|.....:|
Zfish   745 FRKELQGFIDRLEVPKPEERDSEEPLSMFQPIIL 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18304	NP_001260170.1	Smc	404..1202	CDD:224117	160/839 (19%)
		CENP-F_N	1012..1286	CDD:287456	16/89 (18%)
		ATP-synt_B	<1180..1231	CDD:304375
		LCD1	1485..>1594	CDD:286837
soga3b	XP_005162464.1	DUF3166	362..456	CDD:288256	34/200 (17%)
soga3b	XP_005162464.1	DUF3166	488..584	CDD:288256	21/105 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4787
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15742
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	3	2.960