Protein Alignment CG18304 and Mtcl2

DIOPT Version :10

• Sequence 1: NP_001260170.1
• Gene: CG18304 / 33969
• FlyBaseID: FBgn0031869
• Length: 1901
• Species: Drosophila melanogaster
• Sequence 2: XP_017447755.2
• Gene: Mtcl2 / 311578
• RGDID: 1563627
• Length: 1897
• Species: Rattus norvegicus
• Alignment Length: 1947
• Identity: 413/1947 - (21%)
• Similarity: 696/1947 - (35%)
• Gaps: 591/1947 - (30%)

  Fly   200 QRSLNSRENSRERSVPRREEESESTAT---PTPVVPDRPERSKSGTSLNQLAQAEQKRAALP--P 259
            :|||...|.:.|...      .||:|.   |.|......||.||            .||..|  |
  Rat   233 RRSLRPGEAAMEAPA------GESSARGYGPPPAPAPAAERKKS------------HRAPSPARP 279

  Fly   260 KKVAVASTTTASSSNSSSTSLKTSNSTSASNEVK---VVTSTSSSSTSSSSVRRKEADSVASKEI 321
            |.||..|............:.....::||..:.|   |......:....:.||    ..|.:|..
  Rat   280 KDVAGWSLAKGRRGTGPGAATACGTASSARPDKKGRAVAPGARGAGPRVAGVR----TGVRAKGR 340

  Fly   322 KRQTV----PAASISHSNSTSSTASTASKSQDTNGMQEQMKALKLELETMKTRAEKA-------- 374
            .|...    |....|.::|:|..:..||         |:.:.|.||| .:.:.||.|
  Rat   341 PRPGTGPRPPPPPPSLTDSSSEVSDCAS---------EEARLLGLEL-ALSSDAESAAGGPAGTR 395

  Fly   375 --------------EREKSDILLRRLASMDTASNRTAASEALNLQQKLNEMKEQLDRVTEDKRKL 425
                          .|..:......:|:....|:|...|.:|.......||   ||..|
  Rat   396 TGQPPQPAPSGQQPPRPPASPDEPSVAASSVGSSRLPLSASLAFSDLTEEM---LDCGT------ 451

  Fly   426 NLRMKELENKGSESELRRKLQAAEQICEELMEENQSAKKEILNLQAEMDEVQDTFRDDEVKAKTS 490
                      ||   |.|:|       |||..||...|.||..|:|||.|::|.:.:::|.....
  Rat   452 ----------GS---LMREL-------EELRSENDYLKDEIEELRAEMLEMRDVYMEEDVYQLQE 496

  Fly   491 LQKDLEKATKNCRILSFKLKKSDRKIETLEQERQSSFNAELSNKIKKLEEELRFSNELTRKLQAE 555
            |::.|::|:|.||||.::|:|::|:  :|...:....:.||   |:.||::::.|.:::.:|..|
  Rat   497 LRQQLDQASKTCRILQYRLRKAERR--SLRAAQTGQVDGEL---IRGLEQDVKVSKDISMRLHKE 556

  Fly   556 AEELRNPGKKKAPMLGVLGKSTSADAKFTRESLTRGGSQEDPQHLQRELQDSIERETDLKDQLKF 620
            .|.:    :||...|                       :|:.:.|::.|     .||:|..|:
  Rat   557 LEVV----EKKRMRL-----------------------EEENEGLRQRL-----IETELAKQV-- 587

  Fly   621 AEEELQRLRDRE-RKRVRFSCGTQTEVPLEVVAFPRGTQTVATVQSDMSTSVENLVTSNVAVTQT 684
            .:.||.|.|:.. :||...|.|...:.|           |.....:|:...:......:..:.:.
  Rat   588 LQTELDRPREHSLKKRGTRSLGKTDKKP-----------TAQEDSADLKCQLHFAKEESALMCKK 641

  Fly   685 DFEVPDRNVSIERETMSSPFAGLFPPSSSSRVGQSGSLLFPSAISHVLLSGAGRKLSPTPHPHRL 749
            ..::...|.|::.|.:.  :..|:           |.|  .:|:|       ..:|:..||...
  Rat   642 LTKLAKENDSMKEELLK--YRSLY-----------GDL--DAALS-------AEELADAPHSRE- 683

  Fly   750 APEVHADRDEGISDEDDPAELRILLELNEQEASILRLKVEDLEKENAESKKYVRELQAKLRQDSS 814
                              .||::.|:|.|:||::|..::.:||.||       |.|:|::.....
  Rat   684 ------------------TELKVHLKLVEEEANLLSRRIVELEVEN-------RGLRAEMDDMKD 723

  Fly   815 NG------SKSSLLSLG--TSSSAAE--KKVKTLNEELVQLRRTLTEKEQTVDSLKNQLSKLDTL 869
            :|      ::.|..|||  ...|.||  :.::.:.||...|||:..|.|.....|.|:|:|..:
  Rat   724 HGGGGGPEARLSFSSLGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKYRS- 787

  Fly   870 ETENDKLAKENKRLLALRKASEKTGEVDQKMKESLAQAQRERDELTARLKRMQLEAEDKLPPRTA 934
            |.|.|....|           :....:.:..:|.||.|:.:..||:.::|::|.
  Rat   788 EHELDVTLSE-----------DSCSVLSEPSQEELAAAKLQIGELSGKVKKLQY----------- 830

  Fly   935 KRVNDLTPKSHLKKWVEELEDEISEMRVMLSSSGTDQLKALQSAKGALEEDL------------- 986
                                    |.||:||:.....|.:.||.:..||.|.
  Rat   831 ------------------------ENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPL 871

  Fly   987 ---------RKCKQKLSLAEGDVQRLKLLNGSSSKVSELEQKLKRGDEEAKKLNSKLKDLEDKVK 1042
                     |.|:.:      :.:.|..|...::.||      |..|......|.....|...:.
  Rat   872 GETLEPHAGRLCRAR------EAEALPGLREQAALVS------KAIDVLVADANGFSVGLRLCLD 924

  Fly  1043 KQEAQLKLGETSKSTWESQSKREKEKLSSLEKDMEKQAKEKEKLEAKISQLDAELLSAKKSAEKS 1107
            .:.|.|:|.|...:   |:..|:              ||....:..::|.|..||.:..:.|:.:
  Rat   925 NECADLRLHEAPDN---SEGPRD--------------AKLIHAILVRLSVLQQELNAFTRKADVA 972

  Fly  1108 KSSLEKEIKD----LKTKASKSDSKQVQDLKKQVEEVQASLSAEQKRYEDLNNHWEKLSEETILM 1168
            ..|..||..:    |....|:..:|::...|....:.|      ...:.|| ..||....|.  .
  Rat   973 LGSSGKEQPEPFPALPALGSQGPAKEIMLSKDLGSDFQ------PPDFRDL-LEWEPRIREA--F 1028

  Fly  1169 RAQLTTEKQSLQAELNASKQ----KIAEMDTIRIERTDMARKLSEAQKRIADLQAKALKTVNGNG 1229
            ||      ..|:::.:.|:.    :..:.|:...|..::...|:||...:..||
  Rat  1029 RA------GDLESKPDPSRNFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQ----------- 1076

  Fly  1230 AEYERTVLKNKLAEKEHEYERLRRENEMNIDLVFQLRKDN-DDLNGKLSDYNRIEQAQSSLNGHG 1293
                               |:|.:|.        ||||:. |..|.|:....  |..|.:|
  Rat  1077 -------------------EQLSQER--------QLRKEEADSFNQKMVQLK--EDQQRAL---- 1108

  Fly  1294 ARREAEIRELKEQLQSTELQMKSEVATVRLRYEQQVKNLSGELTSMQRQCERFKKDRDAFKQMLE 1358
            .|||.|       |||..||.:.|     .::..|.||:      :.::.::||.:      .|.
  Rat  1109 LRREFE-------LQSLSLQRRLE-----QKFWSQEKNI------LVQESQQFKHN------FLL 1149

  Fly  1359 VAQKKIGDLKANNTGRQSRGSMHSSDDDDKSKIAYLEQQIGHLEDQLVESRLESSKIKT-ELVSE 1422
            :..|....||     |..:|.:..|::||..::..:::....:|::.:.::...:|..| :..::
  Rat  1150 LFMKLRWFLK-----RWRQGKVLPSEEDDFLEVNSMKELYLLMEEEEMNAQHTDNKACTGDSWTQ 1209

  Fly  1423 RSANE-IK-ISEMQSKLNE-------------------------FEEERV------------IGS 1448
            .:.|| || :::|:..|.|                         :|.||.            .|.
  Rat  1210 NTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHASQMELKAGK 1274

  Fly  1449 GSTKLPGMKTKLELSWQKEREDQQRLLQETSTLARDLRQTLFEVERERDKERLESKRKLDQIKRA 1513
            |:::.||...|..|  |:|||:||.||.|:.:...:|.:.|...||...:|:|:...:|...|:.
  Rat  1275 GASERPGPDWKAAL--QREREEQQHLLAESYSAVMELTRQLQMSERHWSQEKLQLVERLQGEKQQ 1337

  Fly  1514 TEEEMEEGRKKIAELQ--CDLLELRDVHAKLRTSNEKLRRERERYEKELIKRRMEAD-GGD---- 1571
            .|::::|.:.::::||  .:...|:....:.:.::.|..|..:.::||.:.   ||: ||.
  Rat  1338 VEQQVKELQNRLSQLQKAAEPWVLKHSDLEKQDNSWKEARSEKTHDKEGVS---EAELGGTGLKR 1399

  Fly  1572 RKVGALLQTVDELVKIAPDLKIVGSGGSARS----SSSSGYDKNLRPEQPNVRRSRSPSPTLSSS 1632
            .|..:.:...:.|:..:|.|    :||.||:    ||.:....:..|.:|  .:.....|.|.:.
  Rat  1400 TKSVSSMSEFESLLDCSPYL----AGGDARNKKLPSSPAFAFVSAEPIEP--EKDAKEKPVLPAR 1458

  Fly  1633 QITSVLARLAEASEELRKFQR--------------------------VNEDE------------- 1658
            . .|.:..||......|:.||                          |::.|
  Rat  1459 D-CSHMGSLACQEPAGRQMQRSYTAPDKTGIRVYYSPPVARRLGVPVVHDKEGKILIEPGFLFTT 1522

  Fly  1659 ------QERSRMRRSNLRRAASQENDPHGSTSSVASAAGSQRG----------GGRLS------- 1700
                  .|..|:..|:..|.....:.......|.||.:||...          .|.:|
  Rat  1523 AKPKESAEADRLAESSYSRWLCNFSRQRLDGGSGASTSGSGPAFPTALHDFEMSGNMSDDMKEIT 1587

  Fly  1701 ---RNSSNNGSLIRKSLSLDHSIQ----------RDQNIWRQDDGSVSSMQS-----IDSELGGL 1747
               |.:..:|||.||..|......          |..::..|.|...||:.|     ..|.|..
  Rat  1588 NCVRQAMRSGSLERKVKSTSSQTVGLATVGTQTIRTVSVGLQTDPPRSSLHSKSWSPRSSSLVS- 1651

  Fly  1748 VRDSSLDSRLDSRLSGGSTQSDIPRGPRKKKKGIMGKLRSLTKSSRNSESEISI----QGSDSDI 1808
            ||...:.|.||      ...|.|.|.....|.| ..||:..:.|..:|..:.|:    ||..:..
  Rat  1652 VRSKQISSSLD------KVHSRIERPCCSPKYG-SPKLQRRSVSKLDSTKDRSLWNLHQGKQNGS 1709

  Fly  1809 SVA--SDMRSSK--KDLRGRLSGMF---KRSGSASRSESMERAG-SDQR---------------- 1849
            :.|  :..|.|.  :::...||.:|   :.|||   :||:.:.| |:.|
  Rat  1710 AWARSTTTRDSPVLRNINDGLSSLFSVVEHSGS---TESVWKLGMSEARTKPEPPKYGIVQEFFR 1771

  Fly  1850 ------PVAVTVVGHPDGPQPREPPPANSLTPRPIRSI--PKPPSAGA--PTTPTTRRRVAK 1901
                  |...|..|.....:|....||:...|..:..|  .|...||.  ...||...:|.|
  Rat  1772 NVCGRAPSPTTAAGEESSKKPEPLSPASYHQPEGVARILNKKAAKAGGSEEVRPTMLSQVGK 1833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18304	NP_001260170.1	SMC_prok_B	<354..1093	CDD:274008	168/793 (21%)
		SMC_prok_B	831..>1544	CDD:274008	161/787 (20%)
		PHA03307	1657..>1901	CDD:223039	72/335 (21%)
Mtcl2	XP_017447755.2	PHA03307	145..>436	CDD:223039	50/234 (21%)
		SMC_prok_B	<456..783	CDD:274008	102/431 (24%)
		SOGA	620..714	CDD:463264	25/141 (18%)
		SOGA	746..835	CDD:463264	28/135 (21%)
		sbcc	1046..>1414	CDD:129705	95/445 (21%)
		GumC	<1240..>1357	CDD:442439	30/118 (25%)
		DUF4482	1307..1445	CDD:464333	32/144 (22%)