Protein Alignment CG18304 and SOGA1

DIOPT Version :9

• Sequence 1: NP_001260170.1
• Gene: CG18304 / 33969
• FlyBaseID: FBgn0031869
• Length: 1901
• Species: Drosophila melanogaster
• Sequence 2: NP_542194.2
• Gene: SOGA1 / 140710
• HGNCID: 16111
• Length: 1661
• Species: Homo sapiens
• Alignment Length: 1851
• Identity: 382/1851 - (20%)
• Similarity: 670/1851 - (36%)
• Gaps: 592/1851 - (31%)

  Fly   227 PTPVVPDRPERSKSGTSLNQLAQAEQKRAALP--PKKVAVASTTTASSSNSSSTSLKTSNSTSAS 289
            |.|.....|||.||            .||..|  ||.||..|...........:::..|.:.|:.
Human    17 PAPAPAPAPERKKS------------HRAPSPARPKDVAGWSLAKGRRGPGPGSAVACSAAFSSR 69

  Fly   290 NEVK---VVTSTSSSSTSSSSVRRKEADSVASKEIKRQTV----PAASISHSNSTSSTASTASKS 347
            .:.|   |......:....:.||    ..|.:|...|...    |....|.::|:|..:..||
Human    70 PDKKGRAVAPGARGAGVRVAGVR----TGVRAKGRPRSGAGPRPPPPPPSLTDSSSEVSDCAS-- 128

  Fly   348 QDTNGMQEQMKALKLELETMKTRAEKAEREKSDILLRR----------------------LASMD 390
                   |:.:.|.||| .:.:.||.|....:.:...:                      :|:..
Human   129 -------EEARLLGLEL-ALSSDAESAAGGPAGVRTGQPAQPAPSAQQPPRPPASPDEPSVAASS 185

  Fly   391 TASNRTAASEALNLQQKLNEMKEQLDRVTEDKRKLNLRMKELENKGSESELRRKLQAAEQICEEL 455
            ..|:|...|.:|.......||   ||                   ...|.|.|:|       |||
Human   186 VGSSRLPLSASLAFSDLTEEM---LD-------------------CGPSGLVREL-------EEL 221

  Fly   456 MEENQSAKKEILNLQAEMDEVQDTFRDDEVKAKTSLQKDLEKATKNCRILSFKLKKSDRKIETLE 520
            ..||...|.||..|:|||.|::|.:.:::|.....|::.|::|:|.||||.::|:|::|:  :|.
Human   222 RSENDYLKDEIEELRAEMLEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERR--SLR 284

  Fly   521 QERQSSFNAELSNKIKKLEEELRFSNELTRKLQAEAEELRNPGKKKAPMLGVLGKSTSADAKFTR 585
            ..:....:.||   |:.||::::.|.:::.:|..|.|.:.   ||:|.:
Human   285 AAQTGQVDGEL---IRGLEQDVKVSKDISMRLHKELEVVE---KKRARL---------------- 327

  Fly   586 ESLTRGGSQEDPQHLQRELQDSIERETDLKDQLKFAEEELQRLRDRERKRVRFSCGTQTEVPLEV 650
                    :|:.:.|::.|     .||:|..|:  .:.||:|.|:...|:
Human   328 --------EEENEELRQRL-----IETELAKQV--LQTELERPREHSLKK--------------- 362

  Fly   651 VAFPRGTQTVATVQSDMSTSVENLVTSNVAVTQTDF-------------EVPDRNVSIERETMSS 702
                |||:::.  ::|..|.|:.  .|.....|..|             ::...|.|::.|.:.
Human   363 ----RGTRSLG--KADKKTLVQE--DSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLK- 418

  Fly   703 PFAGLFPPSSSSRVGQSGSLLFPSAISHVLLSGAGRKLSPTPHPHRLAPEVHADRDEGISDEDDP 767
             :..|:           |.|  .||:|       ..:|:..||...
Human   419 -YRSLY-----------GDL--DSALS-------AEELADAPHSRE------------------- 443

  Fly   768 AELRILLELNEQEASILRLKVEDLEKENAESKKYVRELQAKLRQDSSNG-------SKSSLLSLG 825
            .||::.|:|.|:||::|..::.:||.||       |.|:|::.....:|       ::.:..:||
Human   444 TELKVHLKLVEEEANLLSRRIVELEVEN-------RGLRAEMDDMKDHGGGCGGPEARLAFSALG 501

  Fly   826 ---TSSSAAE--KKVKTLNEELVQLRRTLTEKEQTVDSLKNQLSKLDTLETENDKLAKENKRLLA 885
               ...|.||  :.::.:.||...|||:..|.|.....|.|:|:|..: |.|.|....|
Human   502 GGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKFRS-EHELDVALSE------ 559

  Fly   886 LRKASEKTGEVDQKMKESLAQAQRERDELTARLKRMQLEAEDKLPPRTAKRVNDLTPKSHLKKWV 950
                 :....:.:..:|.||.|:.:..||:.::|::|.
Human   560 -----DSCSVLSEPSQEELAAAKLQIGELSGKVKKLQY--------------------------- 592

  Fly   951 EELEDEISEMRVMLSSSGTDQLKALQSAKGALEED----------------------LRKCKQKL 993
                    |.||:||:.....|.:.||.:..||.|                      :|.|:.:
Human   593 --------ENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAR- 648

  Fly   994 SLAEGDVQRLKLLNGSSSKVSELEQKLKRGDEEAKKLNSKLKDLEDKVKKQEAQLKLGETSKSTW 1058
               |.:|  |..|...::.||      |..|......|.....|...:..:.|..:|.|...:
Human   649 ---EAEV--LPGLREQAALVS------KAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDN-- 700

  Fly  1059 ESQSKREKEKLSSLEKDMEKQAKEKEKLEAKISQLDAELLSAKKSAEKSKSS--------LEKEI 1115
             |:..|:.:.:.::   :.:.:..:::|.|...:.||.|..:.|..::|.||        |.|||
Human   701 -SEGPRDTKLIHAI---LVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKEI 761

  Fly  1116 ---KDLKTKASKSDSKQVQDLKKQVEEVQASLSAEQKRYEDLNNHWEKLSEETILMRAQLTTEKQ 1177
               |||.:.....|.:.:.:.:.::.|.        .|..||::            :...:...:
Human   762 LLAKDLGSDFQPPDFRDLPEWEPRIREA--------FRTGDLDS------------KPDPSRSFR 806

  Fly  1178 SLQAELNAS-KQKIAEMDTIRIERTDMARKLSEAQKRIADLQAKALKTVNGNGAEYERTVLKNKL 1241
            ..:||.|.| ..:|.|:..:          |:||...:..||
Human   807 PYRAEDNDSYASEIKELQLV----------LAEAHDSLRGLQ----------------------- 838

  Fly  1242 AEKEHEYERLRRENEMNIDLVFQLRKDN-DDLNGKLSDYNRIEQAQSSLNGHGARREAEIRELKE 1305
                   |:|.:|.        ||||:. |:.|.|:....  |..|.:|    .|||.|
Human   839 -------EQLSQER--------QLRKEEADNFNQKMVQLK--EDQQRAL----LRREFE------ 876

  Fly  1306 QLQSTELQMKSEVATVRLRYEQQVKNLSGELTSMQRQCERFKKDRDAFKQMLEVAQKKIGDLKAN 1370
             |||..||.:.|     .::..|.||:      :.::.::||.:      .|.:..|....||
Human   877 -LQSLSLQRRLE-----QKFWSQEKNM------LVQESQQFKHN------FLLLFMKLRWFLK-- 921

  Fly  1371 NTGRQSRGSMHSSDDDDKSKIAYLEQQIGHLEDQLVESRLESSKIKT-ELVSERSANE-IK-ISE 1432
               |..:|.:..|:.||..::..:::....:|::.:.::...:|..| :..::.:.|| || :::
Human   922 ---RWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLAD 983

  Fly  1433 MQSKLNE----FEEERVIGSGSTKLPGMKTKLELSW----------------------------- 1464
            |:..|.|    ..:||   .|.|:|.....|.:.:|
Human   984 MKVTLKELCWLLRDER---RGLTELQQQFAKAKATWETERAELKGHTSQMELKTGKGAGERAGPD 1045

  Fly  1465 -----QKEREDQQRLLQETSTLARDLRQTLFEVERERDKERLESKRKLDQIKRATEEEMEEGRKK 1524
                 |:|||:||.||.|:.:...:|.:.|...||...:|:|:...:|...|:..|::::|.:.:
Human  1046 WKAALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNR 1110

  Fly  1525 IAELQ--CDLLELRDVHAKLRTSNEKLRRERERYEKELIKRRMEADGGDRKVGALLQTVDE---L 1584
            :::||  .|...|:....:.:.::.|..|..:.::||.:. .:|..|...|....:.::.|   |
Human  1111 LSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAVS-EVELGGNGLKRTKSVSSMSEFESL 1174

  Fly  1585 VKIAPDLKIVGSGGSAR-----SSSSSGYDKNLRPEQPNVRRSRSPSPTLSSSQITSVLARLAEA 1644
            :..:|.|    :||.||     ::.:.|:..: .|..|  .:.....|.|||...
Human  1175 LDCSPYL----AGGDARGKKLPNNPAFGFVSS-EPGDP--EKDTKEKPGLSSRDC---------- 1222

  Fly  1645 SEELRKFQRVNEDEQERSRMRRSNLRRAASQENDPHGSTSSVASAAGSQRGGGRLSRNSSNNGSL 1709
                                  ::|...|.|  ||.|.....:..|..:.|
Human  1223 ----------------------NHLGALACQ--DPPGRQMQRSYTAPDKTG-------------- 1249

  Fly  1710 IRKSLSLDHSIQRDQNIWRQDDGSV---------SSMQSIDSELGGLVRDSS---LDSRLDSRLS 1762
            ||...|...:.:....:....:|.:         ::.....:|..||...|.   |.:....||.
Human  1250 IRVYYSPPVARRLGVPVVHDKEGKIIIEPGFLFTTAKPKESAEADGLAESSYGRWLCNFSRQRLD 1314

  Fly  1763 GGSTQSDIPRGPRKKKKGIMGKLRSLTKSSRNSESEISIQGSDSDISVASDMRSSKKDLRGRL-S 1826
            |||..|....||     |....|.           :..:.|:.||     ||:.....:|..: |
Human  1315 GGSAGSPSAAGP-----GFPAALH-----------DFEMSGNMSD-----DMKEITNCVRQAMRS 1358

  Fly  1827 GMFKRSGSASRSESMERAGSDQRPVAVTVVGHPDGPQPREPPPANSLTPR-----PIRS------ 1880
            |..:|...::.|:::..|....:.:....||....| ||......:.:||     .:||
Human  1359 GSLERKVKSTSSQTVGLASVGTQTIRTVSVGLQTDP-PRSSLHGKAWSPRSSSLVSVRSKQISSS 1422

  Fly  1881 -------IPKP---PSAGAPTTPTTRRRVAK 1901
                   |.:|   |..|:|  ...||.|:|
Human  1423 LDKVHSRIERPCCSPKYGSP--KLQRRSVSK 1451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18304	NP_001260170.1	Smc	404..1202	CDD:224117	179/856 (21%)
		CENP-F_N	1012..1286	CDD:287456	54/286 (19%)
		ATP-synt_B	<1180..1231	CDD:304375	11/51 (22%)
		LCD1	1485..>1594	CDD:286837	25/113 (22%)
SOGA1	NP_542194.2	DUF3166	380..474	CDD:288256	28/141 (20%)
		DUF3166	508..597	CDD:288256	28/135 (21%)
		DUF4482	1069..1206	CDD:291484	31/142 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4787
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15742
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.960