DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18304 and soga3

DIOPT Version :9

Sequence 1:	NP_001260170.1	Gene:	CG18304 / 33969	FlyBaseID:	FBgn0031869	Length:	1901	Species:	Drosophila melanogaster
Sequence 2:	XP_005157901.1	Gene:	soga3 / 100332515	-ID:	-	Length:	805	Species:	Danio rerio

Alignment Length:	941	Identity:	199/941 - (21%)
Similarity:	367/941 - (39%)	Gaps:	252/941 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 SLNQLAQAEQKRAALPPKKVAVASTTTASSSNSSSTSL-KTSNSTSASNEV------------KV 294
            |:..:.|.:|::.|..|.:...:.|..||.|..|..|. ||...:|.||..            |.
Zfish     3 SVENMKQQQQQQRASSPGRFKDSPTKAASKSGCSKASASKTGGKSSRSNSPVTVHTGKDRHAGKG 67

  Fly   295 VTSTSSSSTSSSSVRRKEADSVASKEIKRQTVPAASISHSNSTSSTASTASKSQDTNGMQEQMKA 359
            ..:..:|...|.::||.|......:....:...||:..........:...|.|:.:.|.:|..||
Zfish    68 AAAVHASGAESPTLRRAEKGRSTERSGSSEEPYAAAEEPLLGADVVSDQPSSSKPSPGKRESSKA 132

  Fly   360 LKLELETMKTRAEKAE-------RE---KSDIL-------LRRLASMDTASNRTAASEALNLQQK 407
                 :..|..|:.|.       ||   :|:::       |::.:.|.|.:..:..:|.
Zfish   133 -----DGGKQAAKSAVGCGPGFWREGCLQSELIQFHMNKSLKKDSGMTTKTPSSPVTEP------ 186

  Fly   408 LNEMKEQLDRVTEDKRKLNLRMKELENKGSESELRRKLQAAEQICEELMEENQSAKKEILNLQAE 472
                    .|..||.|:....:.|.:            |..|:..|.|.:||...|.||..::||
Zfish   187 --------QRPPEDTRRPAEPLPEPD------------QELEEEIERLQDENDFLKHEIDEMRAE 231

  Fly   473 MDEVQDTFRDDEVKAKTSLQKDLEKATKNCRILSFKLKKSDRKIETLEQERQSSFNAELSNKIKK 537
            |||::|||.:::......::::||:|.||||||.::|:|::||  .:........::||   ::.
Zfish   232 MDEMRDTFYEEDACQLQDMRRELERAHKNCRILQYRLRKAERK--RMRYAETGEIDSEL---LRS 291

  Fly   538 LEEELRFSNELTRKLQAEAEELRNPGKKKAPMLGVLGKSTSADAKFTRESLTRGGSQEDPQHLQR 602
            ||::|:.:.:::.:|.   .||.|...|:|        .|..:.:..|:.|.      :.:..::
Zfish   292 LEQDLKVAKDVSVRLH---NELENVEDKRA--------RTDDENERLRQQLI------EVEVTKQ 339

  Fly   603 ELQDSIERETDLKDQLKFAEEELQRLRDRERKRVRFSCGTQTEVPLEVVAFPRGTQTVATVQSDM 667
            .||:.:::..||  .||...:::|:...|..:       |.||...|            .::..:
Zfish   340 ALQNELDKTKDL--SLKRRGKDVQKSEKRTPQ-------TPTEEENE------------DLKCQL 383

  Fly   668 STSVENLVTSNVAVTQTDFEVPDRNVSIERETMSSPFAGLFPPSSSSRVGQSGSLLFPSAISHVL 732
            :...|..|.....:.:.|.| .||   :|:|...                              .
Zfish   384 AFIKEEAVLMRKKMAKIDKE-KDR---LEQELQK------------------------------Y 414

  Fly   733 LSGAGRKLSPTPHPHRLAPEVHADRDEGISDEDDPAELRILLELNEQEASILRLKVEDLEKENAE 797
            .|..|...||.|......|....:           :||::.|.|.|:||:||..|:.:||.||
Zfish   415 RSFYGDVDSPLPKGEAGGPPTTRE-----------SELKLRLRLVEEEANILGRKIVELEVEN-- 466

  Fly   798 SKKYVRELQAKLRQDSSNGSKSSLLSLGTSSSAAEKKVKTLNEELVQLRRTLTEKEQTVDSLKNQ 862
                 |.|:|:|  |...|.:       .:..||:...:..:|.|.:||:.|...|...:.|:..
Zfish   467 -----RGLKAEL--DDLRGDE-------LTGGAADSSSREQSEALSELRQQLQLVEDEAELLRRN 517

  Fly   863 LSKLDTLETENDKLAKENKRLLALRKASEKTGE----------VD----QKMKESLAQAQRERDE 913
            |:   .:|.:|.|:..|      |.|...|.|.          ||    :.::|.|..|:.:.:|
Zfish   518 LA---DVEEQNTKMTSE------LNKLKYKAGSHEGSRYSSSAVDGAKLEALQEELKAARLQINE 573

  Fly   914 LTARLKRMQLEAEDKL------------------PPRTAKRVND------------LTPKSHLKK 948
            |:.::  |||:.|:::                  .||.:...:|            |||  |.|:
Zfish   574 LSGKV--MQLQYENRVLLSNMQRYDLASHLGIRGSPRDSDAESDCGRRESDDDCSRLTP--HRKR 634

  Fly   949 ----WVEELEDEISEMRVMLSSSGTDQLKALQSAKGALEEDLRKCKQKLSLAEGDVQRL-----K 1004
                ..|...:|:..:|.:..:      ::|.:.:|.......|.:|::.....:.:||     :
Zfish   635 EGPVGGESDSEEVRNIRCLTPT------RSLYTPEGRFLSRSFKDRQQMIDIRMEAERLSRTIDR 693

  Fly  1005 LLNGSSSKVSELEQKLKRGDEEAKKLNSKLKDLED--KVKKQEAQLKLGETSKSTWESQSKREKE 1067
            |:..:|:.::|....|..|:     |..:|.|.|:  ::::.|...::        .:|.|..::
Zfish   694 LIADTSTIIAEARVYLNNGE-----LFGRLDDEEEGGRIREHELLYRI--------NAQMKAFRK 745

  Fly  1068 KLSSLEKDMEKQAKEKEKLEAKISQLDAELL 1098
            :|.:....:|....|..:.|..:|.....:|
Zfish   746 ELQNFIDRLEVPKPEDRESEEPLSMFQPIIL 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18304	NP_001260170.1	Smc	404..1202	CDD:224117	159/750 (21%)
		CENP-F_N	1012..1286	CDD:287456	16/89 (18%)
		ATP-synt_B	<1180..1231	CDD:304375
		LCD1	1485..>1594	CDD:286837
soga3	XP_005157901.1	Herpes_ICP4_C	16..>147	CDD:332854	30/135 (22%)
		SMC_N	<205..574	CDD:330553	113/481 (23%)
		SOGA	375..469	CDD:314335	30/157 (19%)
		SOGA	496..588	CDD:314335	26/102 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4787
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900