DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18304 and si:ch211-197l9.2

DIOPT Version :9

Sequence 1:	NP_001260170.1	Gene:	CG18304 / 33969	FlyBaseID:	FBgn0031869	Length:	1901	Species:	Drosophila melanogaster
Sequence 2:	XP_001919842.3	Gene:	si:ch211-197l9.2 / 100001876	ZFINID:	ZDB-GENE-091204-369	Length:	1431	Species:	Danio rerio

Alignment Length:	1829	Identity:	357/1829 - (19%)
Similarity:	646/1829 - (35%)	Gaps:	556/1829 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 NSRENSRERSVPRREEESESTATPTPVVPDRPERSKSGTSLNQLAQAEQKRAALPPKKVAVASTT 268
            |...|:|.....|..:::::....:   ..:|.|.........:...:.:..::||.:.......
Zfish     9 NPESNARSSHHGRDGQDNKACGDSS---SQQPSRQIHRHHAQHMTSKQPQAKSVPPAQNKTKEIF 70

  Fly   269 TASSSNSSSTS-LKTSNSTSASNEVKVVT-STSSSSTSSSSVRRKEAD-SVASKEIKRQTVPAAS 330
            :.......|.| :.|.|:.:...|:|..: ..|..|:|.||.|||.:| |:.|.::.:.:..|..
Zfish    71 SKKPKRGPSPSAVLTPNTHAGKKEMKPESKKRSGGSSSKSSSRRKLSDGSITSDDLSKDSGCATG 135

  Fly   331 ISHSNSTSSTASTASKSQDTNGMQEQMKALKLELETMKTRAEKAEREKSDILLRRLASMDTASNR 395
            ...|..:||..|.||         |:.|.: .:.|.|...||:....:.|.|:....|.......
Zfish   136 KLSSTDSSSEISDAS---------EENKQI-TDAERMDGSAEQRAEHREDGLVNATLSPGLGFGE 190

  Fly   396 TAASEALNLQQKLNEMKEQLDRVTEDKRKLNL----RMKELE---NKGSESELRRKLQAAEQICE 453
            .:.|..           :|...|:.|.. |||    ...:|.   ..|...:|.|::       :
Zfish   191 GSISPG-----------DQTSYVSLDSH-LNLSTSVAFSDLTGDFTDGVHEDLLREI-------D 236

  Fly   454 ELMEENQSAKKEILNLQAEMDEVQDTFRDDEVKAKTSLQKDLEKATKNCRILSFKLKKSDRKIET 518
            :|..||:..|.|:..|::||.|::|.:.:|:|.....|::.||:|.|.||||.::|:|::|:  :
Zfish   237 DLRSENEYLKDEMEELRSEMLEMRDLYMEDDVYQLQDLRQQLEQANKACRILQYRLRKAERR--S 299

  Fly   519 LEQERQSSFNAELSNKIKKLEEELRFSNELTRKLQAEAEELRNPG----------KKKAPMLGVL 573
            |...:....:.||   |:.||.::|.:..::.:|..|.|.::...          :::...|.|.
Zfish   300 LRVAQTGQVDGEL---IRTLEHDIRVAKSVSIRLHGELEAVQKKNSRLEWDNEELRERLQDLEVA 361

  Fly   574 GKSTSADAKFTRESLTRGGSQEDPQHLQREL--QDSIERETDLKDQLKFAEEELQRLRDRERKRV 636
            .:...|:...::.||.|...:......:::|  ||.   ..|||.||.||:||...:
Zfish   362 KQVLQAEMDKSQNSLKRRSLRSTSSKSEKKLSPQDD---SADLKCQLHFAKEESALM-------- 415

  Fly   637 RFSCGTQTEVPLEVVAFPRGTQTVATVQSDMSTSVENLVTSNVAVTQTDFEVPDRNVSIERETMS 701
               |...|:                                               :::|.|||.
Zfish   416 ---CKKLTK-----------------------------------------------MALESETMR 430

  Fly   702 SPFAGLFPPSSSSRVGQSGSLLFPSAISHVLLSGAGRKLSPTPHPHRLAPEVHADRDEGISDEDD 766
            ...|                       .:.||.|.             ..|..|......|....
Zfish   431 EQLA-----------------------KYRLLYGE-------------VDETQAAAGATNSTHTR 459

  Fly   767 PAELRILLELNEQEASILRLKVEDLEKENAESKKYVRELQAKLRQDSSNGSKSSLLSLGTSSSAA 831
            .||:::.|.|.|:||::|..::.:||.||    :.:|...::||:...:..:..::......||.
Zfish   460 EAEVKVHLRLVEEEATLLSRRIVELEVEN----RGLRAEMSELRERGGSLEEDEVMKGAGEGSAL 520

  Fly   832 EKKVKTLNEELVQLRRTLTEKEQTVDSLKNQLSKLDTLETENDKLAKENKRLLALRKASEKTGEV 896
            ..:    |.|..::.|.:..||           |.|.:...|:  .:||:    :.:.:| |..:
Zfish   521 PLR----NGEQEEMLRGMDGKE-----------KADPVSNHNN--TQENQ----MHEHAE-TSSI 563

  Fly   897 DQKMKE-------SLAQAQRERD-------ELTARLKRMQ--LEAEDK-----------LPPRT- 933
            .|.::|       .|:...:|.|       |.|..:|.::  |...|:           :.|.|
Zfish   564 SQMLREGPIGGEQELSMETKEEDGESQCKSEFTFGVKDLEGLLAIHDQALLVRSAIQFLMAPATN 628

  Fly   934 ---------------AKRVNDLTPKSHLKKWVEELEDEISEMRVMLSSSGTDQLKALQSAKGALE 983
                           ......:.|:....:|:  |:..:|.:        |:.|:.||:...||.
Zfish   629 GMSLTCTHKTAPGAPYSNKTSVDPQCKTHQWI--LDPMLSPL--------TNGLEVLQAQLCALI 683

  Fly   984 EDLRKCKQKLSLAEGDVQRLKLLNGSSSK------VSELEQKLKRGDEEAKKL---------NSK 1033
            |.|.                .|||..:|:      :..:.:.:|...|:||..         |..
Zfish   684 EKLE----------------VLLNSENSEPVTDKNIFNVGEDVKAVKEDAKSQARQECHCEGNGV 732

  Fly  1034 LKDLEDKVKKQEAQLK-------LGETS----KSTWESQSKREKEKLSSLEKDMEKQAKEKEKLE 1087
            ....||.:.....||:       .||.|    |:.:|...:.:...|    ||...:...:||..
Zfish   733 TGCSEDSLILLTLQLRWFIQQWQQGERSVGDGKTLFEVYCQNDLHLL----KDTACKYNLQEKCN 793

  Fly  1088 AKISQLDAELLSAKKSAEKSKSSLEKEIKDLKTKASKSDSKQVQDLKKQVEEVQASLSAEQKRYE 1152
               ||:::.|||..::|          ::||.::..: ..:..|.:..|....:||.:.|....:
Zfish   794 ---SQMNSVLLSDLRTA----------LQDLFSELWE-QHRASQCVVHQFANAKASWAVECAELK 844

  Fly  1153 DLNNHWEKLSEETILMRAQLTTEKQSLQAELNASKQKIAEMDTIRIERTDMARKLSEAQKRIADL 1217
            .|.|..|..|..|.:          ...::|||:.||      ..:|:  :.:.|:|:...:.|
Zfish   845 SLINRLEGPSVNTGV----------KCPSDLNAALQK------AHVEK--LQQLLAESYTAVMD- 890

  Fly  1218 QAKALKTVNGNGAEYERTVLKNKLAEKEHEYERLRRENEMNIDLVFQLRKDNDDLNGKLSDYNRI 1282
                               |..:|..:|..:...|||      |:       :.||.|     ::
Zfish   891 -------------------LTRQLKVRESRWSSERRE------LL-------EHLNHK-----KL 918

  Fly  1283 EQAQSSLNGHGARREAEIRELKEQLQSTELQMKSEV-ATVRLRYEQQVKNLSGELTSMQRQCERF 1346
            ||..|..    |:...|::..:.::.|.:..|:..| .|...:..:..|.||.|...:.|:
Zfish   919 EQDVSKT----AQHNGEVQTPRHKMMSKDGNMQRMVLKTAMTKPNKNWKYLSHEAALLDRE---- 975

  Fly  1347 KKDRDAFKQM-LEVAQKKIGDLKANN--TGRQSRGSMHSSDDDDKSKIAYLEQQIGHLEDQLVES 1408
                ||.|.. ..:.......|..|:  |.|.     |::.:....:|.|
Zfish   976 ----DACKTWDCPIMPPSFPGLNLNHELTPRS-----HTAPERTSIRIYY--------------- 1016

  Fly  1409 RLESSKIKTELVSERSANEIKISEMQSKLNEFEEERVIGSGSTKLPGMKTKLELSWQK------- 1466
                        |..||..|::|.:                   :||.:.:.|.|.|.
Zfish  1017 ------------SPPSAKRIQMSSL-------------------IPGEEEEQEESQQPHFTAASS 1050

  Fly  1467 --EREDQQRLLQETSTLARDLRQTLFEVE--RERDKERLESKR--KLDQIKRATEEEMEEGRKKI 1525
              |::|.      .||....||...|:.:  .|||.|.....|  .:....|.....|:..
Zfish  1051 GLEKQDW------VSTYENWLRSLSFDCQSLMERDSESSSGLRTSSIGSPSRLAFNSMDVS---- 1105

  Fly  1526 AELQCDLLELRDVHAKLRTSNEKLRRERERYEKELIKRRMEADGGDRKVGALLQTVDELVKIAPD 1590
            |.|..|:.|:  ..:.|:.|:              ::|:...|.|.:.|.
Zfish  1106 ANLSDDMKEI--TASVLQPSS--------------LERKRAKDFGSKVVS--------------- 1139

  Fly  1591 LKIVGSGGSARSSSSSGYDKNLRPEQP-NVRRSRSPSPTLSS------SQITSVLARLAEASEEL 1648
               |.|.|:...|........|:.:.| |:..::..||.::|      .|.::.|.|::|
Zfish  1140 ---VASTGTQTQSRPQVTTIGLQTDGPRNLYAAKHWSPRVTSFVSTRTQQTSAPLERVSE----- 1196

  Fly  1649 RKFQRVNEDEQERSRMRRSNLRRAASQENDPHGSTSSVASAAGSQRGGGRLSRNSSNNGSLIRKS 1713
             :||..|...:.:.|...|:|:.:         |::||:|::.        ...||.:.|.:..|
Zfish  1197 -RFQPHNTSPKIQRRHSASSLKSS---------SSTSVSSSSS--------FTTSSLSSSSLSAS 1243

  Fly  1714 LSLDHSIQRDQNIWRQDDGSVS--SMQSIDSELG---------GLVRD--SSLDSRLDSRLSGGS 1765
            ..||:. .:::.:|.......:  |||:.|...|         |||.:  .::..|      |..
Zfish  1244 SRLDYG-TKERGLWASPSNRPNSVSMQTSDKPGGRKNVGVHKYGLVHEFLRNVCGR------GEK 1301

  Fly  1766 TQSDIPRGPRKKKKGIMGKLRSLTKSSRNSE------SEISIQGSDSDISVASD---MRSSKKDL 1821
            |..::.:.|..::..:     ||...|:.||      ..:::..:||...:.:.   .::.|::.
Zfish  1302 TNIEMEKAPVARRDHV-----SLAAGSKKSEHPPSRIPAVTVVRNDSITKIVNRRFMKQNQKEEA 1361

  Fly  1822 RGRLSGMFKR---SGSASRSESMERAGSDQRPVAVTVVGHPDGPQPREPPPANSLTPRPIRSIPK 1883
            ..:.....:|   .||.||::.:|....|....::|...       ..|...||   ||.::.|:
Zfish  1362 VCQSQTQTQRQTDKGSISRNKGLEEGACDCSSRSLTSCF-------ARPSQKNS---RPSQNKPR 1416

  Fly  1884 ----PPSAG 1888
                |||.|
Zfish  1417 SHEHPPSRG 1425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18304	NP_001260170.1	Smc	404..1202	CDD:224117	175/885 (20%)
		CENP-F_N	1012..1286	CDD:287456	58/299 (19%)
		ATP-synt_B	<1180..1231	CDD:304375	9/50 (18%)
		LCD1	1485..>1594	CDD:286837	20/112 (18%)
si:ch211-197l9.2	XP_001919842.3	DUF3166	397..491	CDD:288256	34/194 (18%)
si:ch211-197l9.2	XP_001919842.3	DUF3166	459..>532	CDD:288256	19/80 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15742
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100