DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hrb27C and Msi2

DIOPT Version :9

Sequence 1:	NP_001162897.1	Gene:	Hrb27C / 33968	FlyBaseID:	FBgn0004838	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	XP_006534494.1	Gene:	Msi2 / 76626	MGIID:	1923876	Length:	378	Species:	Mus musculus

Alignment Length:	420	Identity:	130/420 - (30%)
Similarity:	187/420 - (44%)	Gaps:	115/420 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EDERGKLFVGGLSWETTQENLSRYFCRFGDIIDCVVMKNNESGRSRGFGFVTFADPTNVNHVLQN 67
            :.:.||:|:|||||:|:.::|..||.:||:|.:|:||::..:.|||||||||||||.:|:.||..
Mouse    17 QHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQ 81

  Fly    68 GPHTLDGRTIDPKPCNPRTLQKPK---KGGGY----------------------KVFLGGLPSNV 107
            ..|.||.:|||||...||..| ||   :||.:                      |:|:|||.:|.
Mouse    82 PHHELDSKTIDPKVAFPRRAQ-PKSQEQGGSWKRTWTTVQARAASGDQMVTRTKKIFVGGLSANT 145

  Fly   108 TETDLRTFFNRYGKVTEVVIMYDQEKKKSRGFGFLSFEEESSVEHVTNERYINLNGKQVEIKKAE 172
            ...|::.:|.::|||.:.::|:|:...:.|||||::||.|..||.|....:..:|.|.||.|||:
Mouse   146 VVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQ 210

  Fly   173 PRDGSGGQNSNNSTVGGAYGKLGNECSHWGPHHAPINMMQGQNGQMGGPPLNMP--------IGA 229
            |::                                :....|..|:..|.|..|.        :|.
Mouse   211 PKE--------------------------------VMFPPGTRGRARGLPYTMDAFMLGMGMLGY 243

  Fly   230 PNMMP----GYQGWGTSPQQQQYGYGNSGPGSYQGWGAPPGPQGPPPQWSNYAGPQQTQGYGGYD 290
            ||.:.    ||.|:..|     |||.......|.....|....||...    |.....:|    .
Mouse   244 PNFVATYGRGYPGFAPS-----YGYQFPALLPYLNASFPAAAYGPVAA----AAVAAARG----S 295

  Fly   291 MYNSTST----GAPSGPSGGGSWNSWNMPPNSAGPTGAPGAGA-GTATDMYSRAQAWATGGPSTT 350
            :.||.|.    |||:.|:|.          |.|.|.|.|||.: |...|:|         ||::.
Mouse   296 VLNSYSAQPNFGAPASPAGS----------NPARPGGFPGANSPGPVADLY---------GPASQ 341

  Fly   351 GPVGGMPRTGPGNSASKSGSEYDYGGYGSG 380
            .       :|.||..| :.|.....|:|.|
Mouse   342 D-------SGVGNYIS-AASPQPGSGFGHG 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrb27C	NP_001162897.1	RRM1_DAZAP1	8..89	CDD:241018	43/80 (54%)
Hrb27C	NP_001162897.1	RRM2_DAZAP1	94..173	CDD:240773	32/100 (32%)
Msi2	XP_006534494.1	RRM1_MSI	23..97	CDD:241020	40/73 (55%)
		PABP-1234	<35..363	CDD:130689	120/400 (30%)
		RRM2_MSI	135..208	CDD:240769	28/72 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4205
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1565323at2759
OrthoFinder	1	1.000	-	-		FOG0000417
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1869
SonicParanoid	1	1.000	-	-		X310
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850